May contain inaccuracies · Check primary sources · Not medical advice · Not for human or animal use

Non-peptide

Adrafinil

Also known as

Olmifon · CRL-40028 · CRL 40028 · adrafinyl

Community talk. May contain inaccuracies. Not medical advice. Not a protocol. Not for human or animal use.

Adrafinil is a wakefulness compound that the body converts to modafinil. People discuss it for getting through tired work or study days, but reports range from useful alertness to little effect, fatigue or anxiety. Its relationship to modafinil does not make the two interchangeable.

What it is and why people discuss it

  • Adrafinil, Olmifon and CRL-40028 refer to the same compound. It is a non-peptide drug; Olmifon is the historical medicine name. Oral pills and capsules appear in community accounts, while informal powders and other routes bring additional uncertainty about the actual exposure. Official context Reddit Reddit
  • A precursor to modafinil, with its own experience reports. A precursor, or prodrug, is changed by the body into an active drug. Human analytical research identifies modafinil after Adrafinil exposure, but that does not establish a reliable milligram conversion or an identical effect. Official context
  • Fladrafinil and flmodafinil are different identities. Similar names can obscure different chemicals. They are listed separately from Adrafinil in the sport rules; neither their numbers nor their testimonials are interchangeable with Adrafinil reports. Official context

Benefits people report

  • Less tiredness and more usable attention. One commenter describes feeling focused at 400–450 mg; another reports less tiredness at 300 mg. A separate 600 mg respondent felt tired instead. These brief accounts do not establish improved learning or reliable productivity. Reddit
  • Awake does not necessarily mean motivated. The long-day writer stayed with mental work but still needed motivation. Substantial caffeine co-use prevents attributing the useful day to Adrafinil alone. Personal report

Doses people discuss

  • 300 mg oral appears in both positive and null reports. One morning-pill user describes clearer thinking; another tried 300 mg capsules twice without benefit. These are individual reports, not a recommended amount or a success rate. Reddit
  • 150 mg, 300 mg and 600 mg had different results in one log. The author reports little change at 150 mg, wakefulness at 300 mg and marked fatigue at 600 mg. Formulation is unspecified; the empty-stomach account implies oral use. More did not mean a better response. Personal report
  • 150 mg plus 300 mg was a 450 mg session total. The comparison writer took the second amount three hours after the first while sleep deprived. That sequence is not evidence for a standard daily dose or a modafinil conversion ratio. Reddit

Half-life discussed in the community

  • Around 16 hours is an uncited forum claim. A commenter in a product-review thread uses that number to explain accumulation and sleep interference without clearly separating Adrafinil from its active metabolite, modafinil. It is not a verified Adrafinil half-life. Reddit
  • The parent-drug half-life remains unresolved here. Half-life measures how long a substance’s amount takes to fall by half. These reports do not measure that; hours of alertness or a difficult bedtime cannot supply the missing value. Reddit Personal report

When people notice it

  • About 90 minutes in one 300 mg account. The product-review writer places relief from tiredness at that point. The morning-pill user separately reports about two hours. Neither timing is a blood-concentration peak. Personal report Reddit
  • The very fast report changed on follow-up. The long-day writer initially estimated 15 minutes, then said under 45 minutes and acknowledged possible placebo. Caffeine timing was disputed in the replies; this is one uncertain account, not a dependable rapid onset. Personal report

How long people feel it

  • Eight to ten hours after onset in one morning-pill report. The same user first noticed it at about two hours. Another writer describes a 10–12-hour effect at 300 mg, without clearly defining whether that clock starts at swallowing or onset. Reddit Personal report
  • Sleep disruption can outlast useful work. The caffeine-heavy long-day account describes insomnia despite 10am use. That illustrates a possible cost, but it cannot separate Adrafinil from the caffeine or establish a predictable sleep-safe cutoff. Personal report

Repeated use and breaks

  • Months of use and spaced days are different habits. The morning-pill user describes several months at a time and one or two days of self-described withdrawal on stopping. The long-day writer describes two-to-three-day breaks. Neither establishes an effective or safe cycle. Reddit Personal report
  • Tolerance reports are inconsistent. A comparison-thread reply describes initial wakefulness that stopped recurring. The long-day author did not notice tolerance with breaks; differing sleep, caffeine and exposure make this an unreliable tolerance-reset rule. Reddit Personal report

What can outweigh the benefit

  • Serious skin reactions have been reported for Adrafinil itself. The French HAS review records Stevens–Johnson syndrome and toxic epidermal necrolysis, potentially life-threatening skin reactions. A new rash needs prompt medical assessment; blistering or mouth sores require urgent attention. Official context
  • Anxiety, insomnia and other unwanted effects matter. The same review describes agitation, confusion, headaches, stomach pain and abnormal movements. Community reports also describe dry eyes and fatigue; one author’s initial next-day headaches later stopped, rather than persisting unchanged. Official context Personal report
  • Caffeine can make an unpleasant experience worse. In the product-review log, adding 150 mg caffeine to 600 mg Adrafinil produced severe anxiety and headache. This is a warning from one report, not evidence that another combination is safe. Personal report
  • Liver reassurance is not established by a diary. The long-day writer worries about liver damage but supplies no liver tests. These accounts establish neither a rate of injury nor a harmless duration of use; feeling fine cannot settle the question. Personal report
  • U.S. scheduling and drug approval are separate. FDA describes Adrafinil among unscheduled modafinil analogs in its 2023 material. No Adrafinil entry was found in the DEA list dated August 27, 2026; this name check does not certify legal sale, importation or use. Official context Official context
  • Adrafinil is prohibited in competition under WADA’s 2026 rules. It appears in S6.A. This sport restriction is separate from U.S. scheduling and does not offer a clearance window. Official context

What the community comparisons add

  • The modafinil comparison runs in both directions. The original poster found Adrafinil weak and modafinil much stronger; another respondent preferred Adrafinil. The first writer’s next-day edit belongs to the same history, and their proposed enzyme explanation was never tested. Reddit
  • A different route is not a lower oral equivalent. One respondent described sublingual use with coffee as “75,” without stating the unit. That report cannot establish an oral amount or a more effective route. Reddit
  • Co-use can blur both benefits and side effects. The morning-pill report includes citicoline for headache. Another contributor tried Adrafinil while sleep deprived and once with phenibut. These are confounders, not evidence that a stack corrects an unwanted effect. Reddit
  • Recent combination enthusiasm still leaves the Adrafinil effect uncertain. An August 2026 writer described added energy with PPAP while also using another substance identified only as MGM. Their two-to-four-day statement does not establish single-dose duration, a repeatable cycle or a treatment for withdrawal; amounts and route were not supplied. Personal report

What formal evidence adds

  • Historical medical use does not prove healthy-user enhancement. The 2011 HAS assessment says Olmifon was no longer marketed and that benefit in its older-adult indications remained insufficiently established. That is distinct from whether a forum writer felt more awake. Official context
  • Detecting a metabolite does not measure cognitive benefit. The human hair study supports the conversion relationship. It does not show how much smarter, more productive or safer a user becomes, and its detection interval is not a felt duration or a half-life. Official context

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