STUDresearch · Peptide
BRP
Also known as
BRINP2-related peptide · BRINP2 related peptide · BRINP-2 · BRINP2 · THRILRRLFNLC · Stanford BRP · natural Ozempic peptide
Community talk. May contain inaccuracies. Not medical advice. Not a protocol. Not for human or animal use.
Peptide
Niche talk
Systemic
IP animal research
Metabolic / GLP-1 class
Systemic 12-amino-acid peptide from BRINP2.
What people say
BRP is an amidated 12-amino-acid BRINP2-related peptide reported in a 2025 Nature paper. The checked evidence is in mice and minipigs, not a human obesity treatment.
Doses people talk about
Mouse mg/kg and intraperitoneal schedules must not be converted into a human syringe or treated as a vendor dose chart.
How it may feel
There is no verified human feel sequence in the inspected material. Community posts mostly discuss the paper, availability and planned experiments rather than completed outcome diaries.
Acute mouse experiments5 mg/kg IP in lean mice; 10 mg/kg IP in DIO mice
Food-intake experiments in the paper, not a human amount or weekly incretin analogue.
Fourteen-day mouse arm5 mg/kg IP daily for 14 days
Obese-mouse body-composition experiment beside liraglutide, not a human cycle.
High acute mouse dose-response20 mg/kg IP
Near-complete short-term intake suppression in the mouse dose-response experiment; not a human amount.
Half-life & effect duration
- Half-life in the body
- Abdominal-cavity injection · miceUnder 10 minutes
- Felt duration people report
- Felt durationNo completed personal-use timeline reported
Cycles people discuss
The paper includes acute injections and a 14-day daily mouse arm. A forum post mentions a planned two-week run, but not a completed or validated human cycle.
Timing
The published mouse program used daily intraperitoneal administration for two weeks. A human self-use schedule is not established, and weekly GLP-1 routines are not interchangeable with that mouse design.
Stacks
The preserved notes describe BRP as a solo pipeline name, not an established stack ingredient. Analogies to incretin combinations are speculative.
Watch for
Zero human AE table. “No nausea” is mouse/pig behavior.
Tap a line for the full notes and source context.
Timing context & sources
Half-life in the body
The paper reports a mouse plasma half-life under 10 minutes after intraperitoneal BRP.
After 0.5, 5, or 10 mg/kg IP in lean male mice, plasma was sampled from 0 to 60 minutes; concentration peaked at 1 minute, with no detectable peak at 0.5 mg/kg.
A one-sided mouse plasma estimate does not establish human or subcutaneous kinetics, brain elimination, depot behavior, subjective duration or a weekly interval.
- Prohormone cleavage prediction uncovers a non-incretin anti-obesity peptide (opens in a new tab)Full text, Fig. 1l and pharmacokinetic methods: 0.5, 5 and 10 mg/kg IP in lean male mice, 0–60-minute sampling, 1-minute plasma peak and reported plasma half-life under 10 minutes; dose-response and 14-day arms are separate.Mouse and minipig experiments; the measured mouse plasma half-life does not establish human exposure, subjective duration, subcutaneous kinetics or human outcomes. Named authors disclose inventor/cofounder interests.
Felt duration people report
No completed human felt-duration report was found in the inspected sources.
The paper reports acute animal food-intake and behavior windows. The community thread asks for experiences and mentions a planned two-week run but supplies no completed outcome diary.
Animal behavior is not human subjective experience; product availability and intent posts do not establish exposure or outcome.
- Prohormone cleavage prediction uncovers a non-incretin anti-obesity peptide (opens in a new tab)Full text, Fig. 1l and pharmacokinetic methods: 0.5, 5 and 10 mg/kg IP in lean male mice, 0–60-minute sampling, 1-minute plasma peak and reported plasma half-life under 10 minutes; dose-response and 14-day arms are separate.Mouse and minipig experiments; the measured mouse plasma half-life does not establish human exposure, subjective duration, subcutaneous kinetics or human outcomes. Named authors disclose inventor/cofounder interests.
- BRP — BRINP2-related peptide (opens in a new tab)hcreque original post and visible comments: request for experiences, planned two-week daily run and availability discussion without a completed outcome follow-up.Intent and availability discussion, not verified exposure, product identity, dosing validation or a completed human diary.
What people say
- No n=1 album. If a log exists, it is a gray vial with no public milligram culture. forum
- Not a food-noise diary compound today. That job is still sema/tirz/reta. forum
- Food-intake animal charts: Single IP shots in lean mice/minipigs — people paste “up to 50% less eating in an hour.” Animal. animal
- Fat without lean wreck (mice): 14-day obese-mouse write-ups: fat down, lean held in the figures people screenshot. animal
- No-nausea pitch: The whole tweet is “Ozempic without the toilet.” That is animal behavior, not a human AE table. animal
- Glucose / insulin mouse talk rides along in the same threads. animal
Doses people talk about
- Do not convert mouse mg/kg into a human syringe. Allometric math is fanfic here. forum
- No public human milligrams. If a listing has a mcg chart, that is vendor copy, not a trial. forum
- Framing: Mouse milligrams-per-kilo. Not a human ladder. Not a protocol. forum
- Paper working shot: 5 mg/kg IP in lean mice; 10 mg/kg in DIO mice. animal
- High animal look: 20 mg/kg in dose-response write-ups — near-total short-term intake suppression in those figures. animal
- 14-day obese-mouse arm: 5 mg/kg daily in the charts next to liraglutide. animal
How it may feel
- Now: Ticker, Nature screenshots, and “is this real” vendor arguments. forum
- If someone pins a research vial anyway: There is no copied hour-by-hour human feel. Do not borrow sema week-1 GI lore and stamp BRP on it. forum
- Stop: No withdrawal story, because almost nobody has a history on a verified bottle. forum
- Mouse clock: Acute intake drop in hours; 14-day fat-mass figures. Not a human titration. animal
- Clinic clock: Merrifield / first-in-human talk was still “planned” in 2026 write-ups — not a posted n=1. trial
Cycles people discuss
- Forum “cycle”: Doesn’t exist as a copied chart. forum
- If a gray vial shows up: People will try to analog from GLP weekly culture. That is identity risk, not a schedule. forum
- Paper model: Daily IP for two weeks in mice — a study arm, not a blast. animal
- Clinic model (hoped): Chronic obesity therapy someday. Not 2026 DIY. trial
Timing
- Sema’s week-long T½ is not this peptide’s T½. forum
- No public human T½. trial
- Measured mouse PK: After single 0.5, 5, or 10 mg/kg IP doses in lean male mice, plasma concentration peaked at 1 minute and the paper reports a plasma half-life under 10 minutes. This does not establish human or subcutaneous kinetics. animal
- Identity is not a depot claim: Amidated BRP is a 12-mer; sequence length alone does not establish clearance or prove the absence of an extended-release formulation. trial
More on what it is
- Why people talk about it: Headlines said “natural Ozempic.” X and peptide shops jumped. Human diaries are basically zero. forum
- Vs sema / reta: Those have human milligrams and GI lore. This has mice, minipigs, and a press cycle. forum
- Already-for-sale problem: Research listings showed up before a registered human trial. Treat the bottle as a name, not Stanford. forum
- What it is: A 12-AA fragment Stanford named BRP (BRINP2-related peptide). Sequence people paste: THRILRRLFNLC, amidated at the tail. The Nature paper is 2025. Merrifield Therapeutics is the clinic-spinout name. trial
- How it works (plain): Not a GLP. Animal write-ups say it hits hunger circuitry in the hypothalamus (POMC / cAMP-PKA-CREB-FOS talk) instead of the gut-GLP receptor everyone already knows. trial
- Amidation is the identity check: Non-amidated BRP was inactive in the paper. A random 12-mer on a COA is not the same thing. trial
Stacks
- Solo pipeline name — not a 2026 screenshot ingredient. forum
- Compared with sema/reta, not stacked with them in the less-stupid posts. Two hunger tools without human PK is noise. forum
- + ATX-304 / MOTS-c shows up as “metabolic pile-on” talk, not a copied protocol. forum
Storage notes
- Clinic product isn’t a BAC-water vial. forum
- If a lyophilized “BRP / THRILRRLFNLC” listing appears, demand amidation on the COA. forum
- Sequence-only powder ≠ Stanford BRP. forum
Watch for
- Gray-vial identity / missing amidation. forum
- Not a GLP. Don’t run a sema ladder and call it this. forum
- Mouse mg/kg ≠ human mg. forum
- Zero human AE table. “No nausea” is mouse/pig behavior. animal
- Pipeline dates slip. A spinout name is not a bottle with a history. trial
Evidence mix
Mixed trial + community tags
Full: every bullet (trial + community). Use Scan for a faster bro-science read.