May contain inaccuracies · Check primary sources · Not medical advice · Not for human or animal use

Non-peptide

Fadogia agrestis

Also known as

Fadogia · Black aphrodisiac · Baakin gagai · Fadogia agrestis stem extract · Fadogia agrestis (Schweinf. Ex Hiern) · Fadogia agrestis (Rubiaceae) · Nigerian fadogia (marketplace shorthand) · FA (forum shorthand) · Fadogia + Tongkat stack (combo product context)

Community talk. May contain inaccuracies. Not medical advice. Not a protocol. Not for human or animal use.

What it is

IdentityAn oral shrub extract discussed for libido, erections and testosterone support, often alongside Tongkat Ali.
Hormone theoryThe proposed LH-like signal is a community explanation, not proof that Fadogia acts as natural hCG or replaces hormone treatment. Extract ratios do not verify active content.
Notes

Fadogia agrestis is an oral plant extract discussed for libido, erections and testosterone support, often alongside Tongkat Ali. Reports range from stronger sexual interest to no benefit and unwanted symptoms; feelings and bloodwork can diverge.

A shrub extract, usually in capsules or powder. Traditional and animal preparations use aqueous stem extract. Modern capsules and powders vary; 10:1 describes processing, not verified hormone-active content. Yakubu et al. 2005: aqueous stem extract in male rats (Animal context · Accessed 2026-09-30)

The hormone story remains a theory. Communities propose stimulating or mimicking luteinizing hormone (LH), which signals testes to make testosterone. Calling it “natural hCG” does not establish a substitute for hormone treatment.

Source context — Yakubu et al. 2005: aqueous stem extract in male rats: Full paper/tables not inspected. Animal findings do not establish human efficacy, LH mimicry, extract equivalence or a human dose.

What people notice

Libido and erectionsSome users report stronger sexual interest or morning erections. One six-week user felt better sexually while testosterone stayed unchanged.
Energy and trainingStack users describe better energy and workouts, no change or anxiety. Tongkat, other supplements, sleep and training often change at the same time.
Unwanted changesAccounts also include worsening libido, fading initial energy, testicular aching, delayed ejaculation and less satisfying orgasms.
Notes

Libido and erections are the clearest reported draw. Users describe more sexual interest, morning erections or testicular fullness. One six-week user felt better sexually without a testosterone change. Fullness is not a measurement of sperm production, fertility or healthy testicular growth. Got any noticeable results from Fadogia Agrestis? (Community discussion · Accessed 2026-09-30)

Better libido can coexist with flat testosterone. Current-Peace5768 reports 600 mg daily for six weeks, improved erections/libido and unchanged testosterone. The same story appears in two threads, so it is one account. Other replies describe slight libido change and fullness without increased risk-taking. Got any noticeable results from Fadogia Agrestis? (Community discussion · Accessed 2026-09-30) · Fadogia Agrestis: Three Weeks In (Personal report · Accessed 2026-09-30)

Energy and gym drive can change in either direction. Stack users describe steadier energy, stronger workouts, no change or anxiety. Tongkat, other supplements, sleep and training often change together, obscuring Fadogia's contribution. Did Tongkat Ali + Fadogia Agrestis Work for anyone else? (Community discussion · Accessed 2026-09-30)

No response and worse libido belong in the same picture. HubermanLab replies include months with no perceived benefit, worsening libido and initial energy that faded after three weeks. A claimed 50/50 response chance is unsupported. Brand quality and placebo are proposed explanations, not established reasons for a null result. Did Tongkat Ali + Fadogia Agrestis Work for anyone else? (Community discussion · Accessed 2026-09-30)

Sexual effects are not uniformly welcome. The same 10:1 log reports delayed ejaculation, less satisfying orgasms and testicular aching, without bloodwork or verified capsule mass. Fadogia 10:1 extract: sexual-function and training log (Personal report · Accessed 2026-09-30)

Source context — Got any noticeable results from Fadogia Agrestis?: Anonymous products and labs unverified. Current-Peace5768 repeats the same experience in Three Weeks In; count as one person.

Source context — Fadogia Agrestis: Three Weeks In: Early self-report, not completed-cycle follow-up. Same six-week commenter also appears in noticeable-results thread.

Source context — Did Tongkat Ali + Fadogia Agrestis Work for anyone else?: Large stacks, no validated diagnoses or causal attribution. Vitamin D table has an implausible unit; it is not reproduced. No numerical response rate inferred.

Source context — Fadogia 10:1 extract: sexual-function and training log: No bloodwork; ZMA, stress and sexual context confound. Invalid removed product link prevents capsule-mass verification. Rat rationale and protective-vitamin claim not adopted.

Doses people talk about

Oral media range300–600 mg/day is the preserved media range. One account used 600 mg daily alone for six weeks; another paired 600 mg Fadogia with 400 mg Tongkat daily.
Other schedulesSeparate reports and charts include 150–300 mg/day, 600 mg every other day or three times weekly, and 1,000–1,200+ mg/day outliers. These do not establish a safe ceiling.
Extract labels425 mg and 500 mg of 10:1 extract are separately named in forum reports. A capsule's mass or ratio does not establish equivalence to another extract or raw powder.
Notes

Oral 300–600 mg/day is the preserved media range. The older record distinguishes 300 mg label servings from the repeated 600 mg daily figure. Fresh reports include 600 mg/day alone for six weeks and 600 mg Fadogia plus 400 mg Tongkat daily; these are reports, not established therapeutic doses. Got any noticeable results from Fadogia Agrestis? (Community discussion · Accessed 2026-09-30) · Did Tongkat Ali + Fadogia Agrestis Work for anyone else? (Community discussion · Accessed 2026-09-30)

Different amounts and frequencies are separate claims. Older discussion includes 150–300 mg/day, about 200 mg of each herb, 600 mg every other day or three times weekly, vendor-described 425–850 mg/day raw/powder-style material, and 1,000–1,200+ mg/day outliers. None establishes a safe ceiling or equivalent exposure.

Capsule mass is not extract potency. Forum accounts separately name 425 mg and 500 mg of 10:1 oral extract. Ratio multiplication does not establish potency; morning/food and empty-stomach habits do not verify absorption. FADOGIA AGRESTIS — Latest Opinion? (Community discussion · Accessed 2026-09-30)

Extract-ratio math: Labels show 10:1, 20:1, 30:1, 50:1, etc.; 600 mg of 10:1 is not equal to 600 mg of 50:1 or to crude powder — forums argue “mg is not interchangeable” without assays or known solvent/plant-part identity. [community]

Source context — Got any noticeable results from Fadogia Agrestis?: Anonymous products and labs unverified. Current-Peace5768 repeats the same experience in Three Weeks In; count as one person.

Source context — Did Tongkat Ali + Fadogia Agrestis Work for anyone else?: Large stacks, no validated diagnoses or causal attribution. Vitamin D table has an implausible unit; it is not reproduced. No numerical response rate inferred.

Source context — FADOGIA AGRESTIS — Latest Opinion?: Commercial sponsor posts exist; no safety endorsement adopted. Keep single-extract and multi-ingredient M-Test separate. Old label attachment images not inspected.

Half-life, onset & duration

Felt onset5–7 days in one large-stack report; roughly 2–3 weeks in others. One user felt nothing or lower libido for the first 1.5 weeks.
Felt durationNo dependable benefit window per capsule. One log peaked around day ten, faded in week four and stopped on day 25; mood and morning erections improved two days later.
Half-lifeThe discussion record does not establish a verified human half-life for these variable plant extracts.
Notes

Five to seven days and roughly two to three weeks both appear. InForced reported improvement after 5–7 days on a large stack. A separate three-week poster felt nothing, possibly lower libido, for 1.5 weeks before improvement; another user described peak effects after a couple of weeks. These are different accounts, not an average onset. Did Tongkat Ali + Fadogia Agrestis Work for anyone else? (Community discussion · Accessed 2026-09-30) · Fadogia Agrestis: Three Weeks In (Personal report · Accessed 2026-09-30) · Got any noticeable results from Fadogia Agrestis? (Community discussion · Accessed 2026-09-30)

No reliable benefit window per capsule is established. One 10:1 capsule log peaked around day ten, faded in week four and stopped on day 25; mood and morning erections improved two days later. Another stack account declined after running out. Course length is not clearance time. Fadogia 10:1 extract: sexual-function and training log (Personal report · Accessed 2026-09-30) · Did Tongkat Ali + Fadogia Agrestis Work for anyone else? (Community discussion · Accessed 2026-09-30)

No verified human half-life is available in this discussion record. Once-daily habits, next-day sensations and hormone checks do not measure elimination. Different commercial extracts have no single validated human clearance number.

Source context — Did Tongkat Ali + Fadogia Agrestis Work for anyone else?: Large stacks, no validated diagnoses or causal attribution. Vitamin D table has an implausible unit; it is not reproduced. No numerical response rate inferred.

Source context — Fadogia Agrestis: Three Weeks In: Early self-report, not completed-cycle follow-up. Same six-week commenter also appears in noticeable-results thread.

Source context — Got any noticeable results from Fadogia Agrestis?: Anonymous products and labs unverified. Current-Peace5768 repeats the same experience in Three Weeks In; count as one person.

Source context — Fadogia 10:1 extract: sexual-function and training log: No bloodwork; ZMA, stress and sexual context confound. Invalid removed product link prevents capsule-mass verification. Rat rationale and protective-vitamin claim not adopted.

Cycles people discuss

Specific accountsOne poster planned six weeks on/three off with Monday–Friday use. Another used a daily Tongkat/Fadogia stack for two months before stopping. A plan is not a completed safety assessment.
Competing calendarsExamples include 3 weeks on/1 week off, 2 weeks on/1 week off, and 4–8 weeks on/2–4 weeks off. These breaks reflect concern, without a proven protective schedule.
Notes

A planned six-week block and a completed account. The three-week poster planned 600 mg on Monday–Friday, six weeks on and three off. This was a plan, not a completed safety assessment. InForced used a daily dual-herb stack for two months before stopping. Fadogia Agrestis: Three Weeks In (Personal report · Accessed 2026-09-30) · Did Tongkat Ali + Fadogia Agrestis Work for anyone else? (Community discussion · Accessed 2026-09-30)

Older schedules disagree widely. The preserved record includes 8–12 weeks on with weeks to a month off, 8 on/2 off, 3 on/1 off, 2 on/1 off, 4–8 on/2–4 off, a month on/1–2 weeks off, and equal time on/off. Every-other-day and three-times-weekly use are also called cycling. Breaks respond to concern, not a proven protective protocol.

3 weeks on / 1 week off: Appears in dual-herb discussion and is sometimes called prudent when testing is sparse. No controlled comparison establishes that this pattern reduces risk. [community]

2 weeks on / 1 week off: Appears in self-experiment logs (including Attia-subreddit-class posts using ~600 mg Fadogia in 2-on/1-off pulses) and some vendor-adjacent risk-reduction habits. [community]

4–8 weeks on / 2–4 weeks off: Vendor and guide language often lands here as a generic on/off example. [community]

Source context — Fadogia Agrestis: Three Weeks In: Early self-report, not completed-cycle follow-up. Same six-week commenter also appears in noticeable-results thread.

Source context — Did Tongkat Ali + Fadogia Agrestis Work for anyone else?: Large stacks, no validated diagnoses or causal attribution. Vitamin D table has an implausible unit; it is not reproduced. No numerical response rate inferred.

Stacks

Tongkat AliThe recurring dual-herb pairing is often described as 400 mg Tongkat plus 600 mg Fadogia daily; lower 200 mg-each experiments also appear. Synergy is not established.
Broader supplement stacksBoron, zinc, vitamin D, magnesium, ashwagandha, fenugreek, maca, tribulus, cistanche and creatine appear. Hormone or gym changes during these stacks cannot identify Fadogia's contribution.
Notes

Tongkat + Fadogia (dominant duo): Podcast-era natural-T template; theory talk is complementary paths (Tongkat free-T / cortisol / aromatase-adjacent lore vs Fadogia LH lore) — not proven synergy. [community]

Classic media stack numbers: Often discussed as ~400 mg Tongkat + ~600 mg Fadogia daily (or lower self-experiments like ~200 mg each) while on Fadogia cycles. [community]

Stacks and continuous use complicate the stories. Older stacks include boron, zinc, vitamin D, magnesium, ashwagandha, fenugreek, maca, tribulus, cistanche and creatine. AnabolicMinds includes continuous blend use by a board sponsor; commercial testimony cannot establish safety or isolate Fadogia. FADOGIA AGRESTIS — Latest Opinion? (Community discussion · Accessed 2026-09-30)

Minerals baseline: Zinc (~15 mg Huberman-adjacent talk; deficiency correction broader), magnesium, vitamin D, boron (~2–4 mg/day in same media stack) framed as free-T/SHBG “floor” — not proven Fadogia potentiators. [community]

Ashwagandha: Stress + libido stacks; sleep/cortisol confounds large; KSM-66/Sensoril brand talk separate from Fadogia evidence. [community]

Creatine / training basics: Performance stacks add creatine and progressive resistance training; any recomp credit is usually lifestyle-first. [community]

Source context — FADOGIA AGRESTIS — Latest Opinion?: Commercial sponsor posts exist; no safety endorsement adopted. Keep single-extract and multi-ingredient M-Test separate. Old label attachment images not inspected.

Watch for

Reported symptomsAnxiety, disturbed sleep, stomach symptoms, irritability and testicular soreness appear. One 600 mg account describes elevated pulse and two sleepless nights with thyroid-product co-use.
Animal safety concernsRat studies reported adverse testicular changes and liver/kidney biochemical signals. These do not prove injury from a given human capsule amount, and cycling or normal panels cannot certify safety.
Identity and hormone contextPlant identity, contaminants, extract potency, fertility effects and hormone-drug interactions remain uncertain. Hormone-sensitive conditions feature in caution talk.
Pregnancy and breastfeedingThe preserved consumer caution advises avoiding use because safety data are lacking; it supplies no measured risk estimate.
Notes

Anxiety, disturbed sleep, GI symptoms and pain appear in reports. Irritability, skin changes and testicular soreness also appear. A liver-pain/enzyme claim remains unverified. Another poster later attributed colored urine to a B-vitamin product; it should not become proof of liver injury. Did Tongkat Ali + Fadogia Agrestis Work for anyone else? (Community discussion · Accessed 2026-09-30)

Early sensations can also be unwanted. Bozidar described a day-long rush after 600 mg on consecutive mornings, with elevated pulse and two sleepless nights. Thyroid-product co-use and cold-like symptoms complicate attribution; this is not proof of fast testosterone action. Fadogia Agrestis: adrenaline and sleep complaint (Personal report · Accessed 2026-09-30)

Testicular changes also raised concern. The 2008 experiment used those doses for 28 days plus ten-day recovery observation. Authors interpreted altered testicular indices as adverse; recovery mainly at the lowest dose does not validate human cycles. Yakubu et al. 2008: male-rat testicular function indices (Animal context · Accessed 2026-09-30)

Liver and kidney signals were biochemical. The 2009 rat study reported enzyme and oxidative-damage-marker changes consistent with membrane disruption, despite no mortality or gross organ enlargement. Animal findings justify uncertainty; they do not prove that a particular human capsule amount causes organ injury. Yakubu et al. 2009: male-rat liver and kidney toxicity (Animal context · Accessed 2026-09-30)

Cycling and normal panels cannot certify safety. Discussion includes hormone panels, CBC/CMP, liver enzymes and kidney markers. These indirect checks do not settle extract identity, fertility, long-term effects or hormone-drug interactions. Hormone-sensitive conditions also feature in caution talk.

A label or brand story does not resolve the uncertainty. Plant identity, contamination, extract ratios and assays remain practical questions. The older record mentions Momentous discontinuation as community risk discussion; that account was not reverified here and is not a regulatory ban.

Pregnancy and breastfeeding: safety data are lacking. Consumer-monograph caution relayed in the preserved discussion is to avoid use during pregnancy or breastfeeding. This is a lack-of-data warning, not a measured risk estimate.

Source context — Did Tongkat Ali + Fadogia Agrestis Work for anyone else?: Large stacks, no validated diagnoses or causal attribution. Vitamin D table has an implausible unit; it is not reproduced. No numerical response rate inferred.

Source context — Fadogia Agrestis: adrenaline and sleep complaint: One uncontrolled account with thyroid products and cold-like symptoms. No drug interaction, measured half-life or incidence can be inferred.

Source context — Yakubu et al. 2008: male-rat testicular function indices: Abstract only, not full text or human fertility evidence. Conflicting acid-phosphatase directions in abstract are not copied. First online publication 2007; journal issue 2008.

Source context — Yakubu et al. 2009: male-rat liver and kidney toxicity: Abstract only. No mortality or gross organ-size change is not proof of safety; no specific human toxic dose inferred.

Full notes

Fadogia agrestis is an oral plant extract discussed for libido, erections and testosterone support, often alongside Tongkat Ali. Reports range from stronger sexual interest to no benefit and unwanted symptoms; feelings and bloodwork can diverge.

Plant extract and uncertain hormone effects

  • A shrub extract, usually in capsules or powder. Traditional and animal preparations use aqueous stem extract. Modern capsules and powders vary; 10:1 describes processing, not verified hormone-active content. Animal context Community
  • The hormone story remains a theory. Communities propose stimulating or mimicking luteinizing hormone (LH), which signals testes to make testosterone. Calling it “natural hCG” does not establish a substitute for hormone treatment. Community

Why people try it

  • Libido and erections are the clearest reported draw. Users describe more sexual interest, morning erections or testicular fullness. One six-week user felt better sexually without a testosterone change. Fullness is not a measurement of sperm production, fertility or healthy testicular growth. Reddit r/Supplements
  • Energy and gym drive can change in either direction. Stack users describe steadier energy, stronger workouts, no change or anxiety. Tongkat, other supplements, sleep and training often change together, obscuring Fadogia's contribution. Reddit r/HubermanLab Community

Doses people discuss

  • Oral 300–600 mg/day is the preserved media range. The older record distinguishes 300 mg label servings from the repeated 600 mg daily figure. Fresh reports include 600 mg/day alone for six weeks and 600 mg Fadogia plus 400 mg Tongkat daily; these are reports, not established therapeutic doses. Community Reddit r/Supplements Reddit r/HubermanLab
  • Different amounts and frequencies are separate claims. Older discussion includes 150–300 mg/day, about 200 mg of each herb, 600 mg every other day or three times weekly, vendor-described 425–850 mg/day raw/powder-style material, and 1,000–1,200+ mg/day outliers. None establishes a safe ceiling or equivalent exposure. Community
  • Capsule mass is not extract potency. Forum accounts separately name 425 mg and 500 mg of 10:1 oral extract. Ratio multiplication does not establish potency; morning/food and empty-stomach habits do not verify absorption. AnabolicMinds Community

Half-life

  • No verified human half-life is available in this discussion record. Once-daily habits, next-day sensations and hormone checks do not measure elimination. Different commercial extracts have no single validated human clearance number. Community

When people first notice something

  • Five to seven days and roughly two to three weeks both appear. InForced reported improvement after 5–7 days on a large stack. A separate three-week poster felt nothing, possibly lower libido, for 1.5 weeks before improvement; another user described peak effects after a couple of weeks. These are different accounts, not an average onset. Reddit r/HubermanLab Personal report Reddit r/Supplements
  • Early sensations can also be unwanted. Bozidar described a day-long rush after 600 mg on consecutive mornings, with elevated pulse and two sleepless nights. Thyroid-product co-use and cold-like symptoms complicate attribution; this is not proof of fast testosterone action. Personal report

How long effects seem to last

  • No reliable benefit window per capsule is established. One 10:1 capsule log peaked around day ten, faded in week four and stopped on day 25; mood and morning erections improved two days later. Another stack account declined after running out. Course length is not clearance time. Personal report Reddit r/HubermanLab

Cycles and breaks

  • A planned six-week block and a completed account. The three-week poster planned 600 mg on Monday–Friday, six weeks on and three off. This was a plan, not a completed safety assessment. InForced used a daily dual-herb stack for two months before stopping. Personal report Reddit r/HubermanLab
  • Older schedules disagree widely. The preserved record includes 8–12 weeks on with weeks to a month off, 8 on/2 off, 3 on/1 off, 2 on/1 off, 4–8 on/2–4 off, a month on/1–2 weeks off, and equal time on/off. Every-other-day and three-times-weekly use are also called cycling. Breaks respond to concern, not a proven protective protocol. Community

What deserves attention

  • Anxiety, disturbed sleep, GI symptoms and pain appear in reports. Irritability, skin changes and testicular soreness also appear. A liver-pain/enzyme claim remains unverified. Another poster later attributed colored urine to a B-vitamin product; it should not become proof of liver injury. Reddit r/HubermanLab Community
  • Cycling and normal panels cannot certify safety. Discussion includes hormone panels, CBC/CMP, liver enzymes and kidney markers. These indirect checks do not settle extract identity, fertility, long-term effects or hormone-drug interactions. Hormone-sensitive conditions also feature in caution talk. Community Community
  • A label or brand story does not resolve the uncertainty. Plant identity, contamination, extract ratios and assays remain practical questions. The older record mentions Momentous discontinuation as community risk discussion; that account was not reverified here and is not a regulatory ban. Community Community
  • Pregnancy and breastfeeding: safety data are lacking. Consumer-monograph caution relayed in the preserved discussion is to avoid use during pregnancy or breastfeeding. This is a lack-of-data warning, not a measured risk estimate. Community

What community experience adds

  • Better libido can coexist with flat testosterone. Current-Peace5768 reports 600 mg daily for six weeks, improved erections/libido and unchanged testosterone. The same story appears in two threads, so it is one account. Other replies describe slight libido change and fullness without increased risk-taking. Reddit r/Supplements Personal report
  • A positive laboratory story still has several explanations. Oscar_gainzorious reports 306 to 508 ng/dL total testosterone during eight weeks of dual-herb use, with an older baseline, P5P, shilajit, ashwagandha and vitamins. Prolactin also rose. The author's numbers cannot isolate Fadogia. Personal report
  • No response and worse libido belong in the same picture. HubermanLab replies include months with no perceived benefit, worsening libido and initial energy that faded after three weeks. A claimed 50/50 response chance is unsupported. Brand quality and placebo are proposed explanations, not established reasons for a null result. Reddit r/HubermanLab
  • Sexual effects are not uniformly welcome. The same 10:1 log reports delayed ejaculation, less satisfying orgasms and testicular aching, without bloodwork or verified capsule mass. Personal report
  • Stacks and continuous use complicate the stories. Older stacks include boron, zinc, vitamin D, magnesium, ashwagandha, fenugreek, maca, tribulus, cistanche and creatine. AnabolicMinds includes continuous blend use by a board sponsor; commercial testimony cannot establish safety or isolate Fadogia. Community AnabolicMinds

What the rat studies do and do not show

  • The initial testosterone evidence was in male rats. Oral aqueous stem extract at 18, 50 and 100 mg/kg every 24 hours increased testosterone and sexual-behavior measures on days 1, 3 and 5 in the 2005 experiment. No human dose follows. Animal context
  • Testicular changes also raised concern. The 2008 experiment used those doses for 28 days plus ten-day recovery observation. Authors interpreted altered testicular indices as adverse; recovery mainly at the lowest dose does not validate human cycles. Animal context
  • Liver and kidney signals were biochemical. The 2009 rat study reported enzyme and oxidative-damage-marker changes consistent with membrane disruption, despite no mortality or gross organ enlargement. Animal findings justify uncertainty; they do not prove that a particular human capsule amount causes organ injury. Animal context

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