STUDresearch · Peptide

Hexarelin

Also known as

Examorelin · HEX · EP-23905 · MF-6003 · His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2 · Hexareline (misspelling)

Community talk. May be wrong. Not medical advice. Not a protocol. Not for human or animal use.

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Peptide Lots of talk Systemic SubQ Growth hormone axis

Systemic — pituitary GHS-R1a (ghrelin receptor) agonist that triggers whole-body GH/IGF-1 axis pulses plus modest ACTH/cortisol and prolactin spillover.

What people say Hexarelin is a synthetic GH-releasing peptide. Forums discuss a strong pulse and recovery, alongside cortisol, prolactin and fading-response concerns; many accounts also include a GHRH partner. Doses people talk about
Community per-pulse charts50–200 mcg subcutaneously per pulse; one to three daily pulses discussed

About 100 mcg is a frequently quoted middle. Some schedules use one or two pulses, while others describe morning, afternoon and bedtime use; these are not comparative dose-finding results.

Upper community reports200–300 mcg subcutaneously per pulse

Frequency varies between logs. Cortisol/prolactin spillover and desensitization concerns accompany upper-end discussion; the reports do not establish added benefit.

Chronic SC study context1.5 mcg/kg subcutaneously twice daily for 16 weeks

The existing Rahim account includes a 105 mcg twice-daily example for 70 kg and a separate four-week washout. Measured GH-response attenuation and recovery do not validate a community cycle.

IV GH-response study0.5, 1 or 2 mcg/kg intravenously per study exposure

Separate clinical dose-response exposures. The measured GH peak and approximately 55-minute released-GH half-life are not a parent-Hexarelin clearance estimate or SC dose guidance.

Reported amounts and study exposures only. Routes, schedules and outcomes differ; a GH response is not parent-peptide clearance or proof of a body-composition benefit.

Half-life & effect duration

Half-life in the body
  • IV · ratsAbout 76 minutes
  • IV · dogsAbout 120 minutes
  • Human parent peptideNo settled estimate
Felt duration people report
  • One logA few spaced-out minutes; relaxing on a later occasion
  • Other accountsRacing mind or trouble sleeping that night
Timing context & sources
How it may feel Reports include flushing, a heavy or tired feeling, appetite changes, brief spaced-out or relaxing sensations, and sometimes energy, racing thoughts or disrupted sleep. Stacks make it hard to separate Hexarelin from the other compounds.

Tap a line to jump into the full notes. Research only — may be wrong.

Timing context & sources

Half-life in the body

Human Hexarelin clearance is not established by the sources checked. The often-cited 55 minutes describes released GH instead.

Separate IV studies report about 76 minutes in rats and 120 minutes in dogs. Neither is a measured human subcutaneous half-life.

Original abstracts reviewed. The human experiment measured GH response after Hexarelin, not parent clearance. The rat mean is 75.9 ± 9.3 minutes; the dog figure is a terminal estimate. No cross-species conversion or claim that no human PK publication exists is made.

Felt duration people report

One log reports a few spaced-out minutes; a later injection felt relaxing. Other accounts describe a racing mind or trouble sleeping that night.

These reports do not establish a fixed benefit window. Co-use makes it hard to separate Hexarelin from the rest of the stack.

Elvia1023's 2014 log involves DAC and anabolic steroids; a supplier-related context is visible. Reddit commenters describe stimulation settling after an unspecified time and a sermorelin/Hexarelin sleep problem. Neither measured duration nor prevalence is inferred, and the guide author's dosing advice is not adopted.

  • Hexarelin and CJC-DAC experience log (opens in a new tab)Elvia1023 post 19, April 25, 2014: a few spaced-out minutes after a pre-workout injection; relaxation after another later injection. Preceding lines disclose concurrent anabolic steroids and DAC.Dated single-person log with multiple compounds and possible commercial affiliation; no isolated effect, universal duration or administration advice adopted.
  • Hexarelin discussion: actual stimulation and sleep accounts (opens in a new tab)cordex69420 follow-up about warm/energized/racing sensations then settling; probablyfine90's account of a sermorelin/Hexarelin combination and a difficult night.Actual first-person comments reviewed, not the guide-like OP as evidence. Unverified products, co-use and unspecified duration; mechanistic guesses and protocol advice not adopted.

What people say 11

  • Potency ranking (bro lore): Common forum hierarchy for GH amplitude at comparable doses: Hexarelin ≥ GHRP-2 > GHRP-6 > Ipamorelin; hexarelin often called “strongest GHRP pulse.” forum
  • Recovery: User logs claim faster training recovery, less DOMS, and better “repair feel” on multi-pulse SC runs—highly confounded by training, sleep, and stacks. forumanecdote
  • Lean mass / recomp: Anecdotes of fuller look, modest recomp, or improved body comp with diet/training; 16-week clinical SC schedule (1.5 µg/kg BID) did not show significant lean-mass/fat change in that trial design. anecdotetrial
  • Sleep (mixed): Some report deeper sleep on bedtime pulses; others prefer daytime-only dosing because cortisol/ACTH spillover or restless nights. forum
  • Appetite: Hunger rise often described as milder than GHRP-6; still present for some users. forum
  • Stack synergy credit: Many benefit reports attribute results to hexarelin + CJC/Mod GRF or sermorelin dual-pulse stacks rather than hexarelin monotherapy. forum
  • Strong acute GH pulse: IV human work—GH rises dose-dependently, peaks ~30 min, returns toward baseline within a few hours; ~1 µg/kg near maximal vs 2 µg/kg adding little extra peak. trial
  • Vs GHRP-2 (head-to-head): Arvat et al.—1 and 2 µg/kg IV GHRP-2 and hexarelin produced similar strong GH responses, both greater than GHRH alone at 1 µg/kg, with similar modest PRL/ACTH/cortisol spillover. trial
  • GHRH synergy: Low-dose hexarelin + GHRH co-admin produced large GH release with less cortisol impact than higher hexarelin alone in dose-response work—mechanistic basis for the classic “GHRH + GHRP same syringe” stack. trial
  • Cardiac research interest: Animal/preclinical ischemia-reperfusion, anti-fibrotic, and CD36-related cardiac work drive “heart health” search interest—not a validated self-experimentation protocol. animal
  • Bone markers (limited): One chronic SC human schedule noted a rise in C-terminal propeptide of type I collagen (formation marker) without clear BMD change in that study window. trial

Doses people talk about 17

  • Community per-injection (SC): Most common talk band ~50–200 mcg subcutaneous per pulse; ~100 mcg is the frequent “middle” starting/standard pulse. forum
  • Aggressive / upper community talk: ~200–300 mcg per pulse appears in advanced logs and some vendor-style charts; spillover (cortisol/prolactin) and desensitization risk discussed more at the high end. forum
  • Total daily community patterns: Classic 2–3 SC pulses/day → rough totals ~200–600 mcg/day depending on per-pulse size; some deliberately use 1–2 pulses/day to limit desensitization. forum
  • Example community schedules (not standardized): Conservative ~100 mcg 1×/day; standard ~100–200 mcg 1–2×/day; “classic multi-pulse” ~100 mcg 2–3×/day (e.g., AM / afternoon / pre-bed). forum
  • Timed example often repeated: Three × 100 mcg spaced through the day (e.g., morning, mid-afternoon, night) for ~300 mcg total daily—one common peptides.org-style chart pattern. forum
  • Weight-scaled clinical band often cited: ~1–2 µg/kg per administration in provocative/SC research contexts; community flat mcg doses (100–200 mcg) are only roughly in that band for typical adult body weights and are not trial-validated flat protocols. trialforum
  • With GHRH stack (community): Common co-inject talk is hexarelin ~100–200 mcg + Mod GRF 1-29 / CJC-1295 no-DAC ~100 mcg (sometimes 100–200 mcg GHRH) same timing; do not double hexarelin just because stacked. forum
  • Empty-stomach timing: Strong community preference—often ~1–2+ hours after food and ~20–30+ minutes before carbs/meals, because insulin/glucose is believed to blunt GH pulses (shared GHRP lore). forum
  • Route note on dose: Human PK/PD peaks in classic papers are largely IV; SC is the forum standard but SC bioavailability is less precisely published than IV—equating community SC mcg to IV trial peaks overstates certainty. trialforum
  • 2026 ceiling talk: 100 mcg remains the middle; 200–300 mcg is framed as more PRL/cortisol, not more GH once you are near the old ~1 µg/kg IV plateau lore. forum
  • Shorter-block discussion versus Ipamorelin: The 2025–26 charts describe 4–8 weeks on followed by time off or rotation to Ipamorelin, often contrasting this with longer Ipamorelin runs because tachyphylaxis is central to Hexarelin discussion. These are attributed calendars, not an established default or optimal block. forum
  • Framing: Research and community discussion ranges only—not medical advice, prescriptions, or safety-validated protocols. Gray-market labeled mcg may not equal delivered peptide. forum
  • Clinical IV dose-response anchors (Imbimbo et al.): Single IV boluses 0.5, 1, and 2 µg/kg; GH Cmax roughly ~27 / ~52 / ~55 ng/mL vs placebo; ED50 for Cmax ~0.50 µg/kg; 2 µg/kg near theoretical max. trial
  • Low-dose + GHRH synergy (Massoud): Hexarelin 0.125 µg/kg IV + GHRH 1.0 µg/kg produced large GH release with moderate PRL and no cortisol rise in that design—cited as rationale for modest GHRP doses when stacked with GHRH. trial
  • Chronic SC research anchor (Rahim et al.): Twice-daily subcutaneous hexarelin 1.5 µg/kg body weight for 16 weeks (example: ~105 mcg BID for a 70 kg subject). trial
  • Ceiling logic from trials: Moving from ~1→2 µg/kg IV added little extra GH peak while spillover hormones still respond—supports community “more is not always more” talk. trial
  • Clinical IV PRL/cortisol dose-response (Massoud et al.): Hexarelin 0–1.0 µg/kg IV—GH plateau near 1.0 µg/kg (ED50 ~0.48 µg/kg); PRL rises dose-dependently (ED50 ~0.39 µg/kg); cortisol showed a step increase ~40% around 0.5 µg/kg. trial

How it may feel 10

  • First injections / days 1–7: Community notes describe little classic “stim” feel, facial flush, brief fatigue or a “heavy” sensation, mild appetite change, injection-site sting and possible sleep shifts near bedtime. An inspected multi-agent log reports a few spaced-out minutes and relaxation after another injection; other combination accounts describe warmth, energy, a racing mind or trouble sleeping. These mixed reports do not isolate Hexarelin or establish a typical effect window. forum
  • Weeks 1–2: Recovery or sleep claims often appear first if they appear at all; possible water retention, joint tightness, or extremity tingling (GH-axis-like). forum
  • Weeks 2–4: Desensitization talk intensifies—users and some literature frame progressive blunting of GH response with frequent chronic dosing; community checkpoint for whether pulses still “feel worth it.” trialforum
  • Weeks 4–8: Common window where many end an intensity block or cut pulse frequency; prolactin/cortisol side chatter more common if doses are high. forum
  • Months 2–3+ continuous: Continuous multi-daily hexarelin less favored than Ipamorelin for long “cruise” style runs; earlier breaks or rotation common. forum
  • If response fades: Community advice is usually stop / time-off rather than escalate mcg (escalation may worsen spillover and receptor downregulation lore). forum
  • After multi-week off: Users claim restored pulse strength; clinical data support partial, reversible attenuation after chronic SC use. trialanecdote
  • Weeks 4–6 fade (2026): Logs describe shrinking “pulse feel” and attribute it to desensitization, while warning against a jump from 100 to 300 mcg. Subjective fading does not measure the GH response or establish an escalation strategy. forum
  • Rotation discussion: The 2025–26 charts describe switching to Ipamorelin for an off-block instead of stacking a second GHRP. This is community practice, not a recommended substitution or proof that the off-block restores response. forum
  • Weeks 8–16 (literature anchor): Rahim chronic SC study—AUC of GH response fell significantly by week 4 and further by week 16 on BID hexarelin, with IGF-I largely unchanged; recovery of GH response after 4-week washout. trial

Around the dose 6

  • Clock: Empty-stomach pulses — AM fasted and/or bedtime. 2026 short-block charts favor 1–2×/day more than old 3×/day blasts. forum
  • Food-timing discussion: Charts repeat the shared GHRP preference for ~2+ hours after food and a carbohydrate delay. This is community GH-response lore, not a universal administration rule or a timing requirement derived from measured parent clearance. forum
  • Sleep: Bedtime pulse is argued. Cortisol/ACTH spillover is why some move hex off the night slot. forum
  • Training context: Older charts frame use as a short intensity block followed by rotation, not a gym-bag pump product. An inspected multi-agent log also describes pre-workout use followed by a few spaced-out minutes. Those are reported patterns, not evidence of an optimal training or administration slot. forum
  • When the response seems to fade: Logs warn against escalating micrograms when the “pulse feel” fades and discuss time off or a switch to Ipamorelin. These are reported alternatives, not evidence that a particular break or substitution is optimal or safe. forum
  • Partner: CJC no-DAC / Mod GRF same timing is the dual-path stack; hex + GHRP-2/6 is still called same-receptor pile-on. forum

Cycles people discuss 9

  • Why cycle talk is heavy: Desensitization / progressive attenuation of GH response with chronic frequent use is better documented for hexarelin than for Ipamorelin and is central to community on/off design. trialforum
  • Shorter intensity blocks: ~4–8 weeks on is a very common forum recommendation (some charts say 4 weeks on / 4 weeks off for stricter tachyphylaxis control). forum
  • Medium blocks: ~8–12 weeks on then multi-week off appears in vendor/clinic-style writeups; peptides.org-style material often cites ~12 weeks research-style admin then ~4 weeks break, echoing chronic-trial washout logic. forum
  • Time-off length (community): Often multi-week off; after longer runs many match ~equal time off or at least ~4 weeks; some prefer longer off than on for hexarelin specifically. forum
  • Lower-frequency / intermittent strategies: Fewer pulses per day, training-days-only, or 5-on/2-off patterns discussed to slow blunting—none are trial-standardized for body-composition outcomes. forum
  • Vs Ipamorelin cycle culture: Hexarelin framed as shorter “intensity / pulse power” blocks; Ipamorelin more often run longer as a selective daily GHRP. forum
  • Re-challenge after break: The existing chronic-SC trial account describes recovery of measured GH response after washout; community logs describe stronger felt pulses after time off. Logs also discourage continuing without a break while escalating the amount. These are different observations and do not establish an optimal re-challenge schedule. trialforum
  • Stack cycle rule of thumb: When hexarelin is stacked with GHRH, cycle length usually follows hexarelin’s shorter desensitization timeline, not an indefinite CJC cruise. forum
  • Literature washout (Rahim): After 16 weeks BID SC, GH response to hexarelin was attenuated; 4 weeks off restored AUC GH toward baseline (partial, reversible attenuation). trial

Timing 10

  • Multi-daily discussion: Community charts use short-action-window logic to describe 2–3 discrete pulses per day rather than weekly-depot or once-weekly use. That is reported scheduling rationale, not a frequency validated by measured human parent-Hexarelin clearance. forum
  • SC pulse window (community): Usable GH elevation often described as roughly ~1–2 hours after subcutaneous injection (less tightly published than IV). forum
  • Food / insulin timing: Empty-stomach preference (~2+ hr after meal, wait before large carb meals) is near-universal GHRP community practice to avoid blunted GH release. forum
  • Bedtime debate: Pre-sleep pulse mimics natural night GH interest for some; others avoid night dosing if cortisol spillover or sleep disruption appears. forum
  • Oral / nasal PK note: Developmental literature describes oral and intranasal activity (often at higher mcg/kg than SC community doses); oral bioavailability is discussed as limited/variable vs injection—injection remains forum standard. trialforum
  • GH peak (IV): Plasma GH rises promptly and peaks at about ~30 minutes after IV bolus in classic human PK/PD. trial
  • Released GH, not Hexarelin clearance: In Imbimbo's human IV experiment, the approximately 55-minute half-life describes plasma growth hormone after Hexarelin; GH peaked around 30 minutes and returned to baseline within 240 minutes. It does not establish the parent peptide's human half-life. trial
  • Hormone spillover timeline: Modest concurrent rises in prolactin, ACTH, and cortisol accompany GH pulses at effective doses—dose-related in IV studies. trial
  • Desensitization dynamics: Progressive blunting with chronic administration; human BID SC data show significant AUC GH drop by week 4 and further by week 16, reversible after ~4 weeks off. trial
  • Downstream IGF-I: Acute GH pulses do not guarantee large IGF-I rises; Rahim chronic SC schedule found IGF-I and IGFBP-3 largely unchanged despite ongoing GH secretagogue exposure—important honesty point for “IGF gains” marketing. trial

More on what it is 6

  • Why people search it: Forums and research blogs cast it as one of the strongest acute GH-pulse GHRPs—often ranked above GHRP-2 and well above Ipamorelin for raw amplitude—while warning it is also among the “dirtiest” for cortisol/prolactin and desensitization. forum
  • What it is: Synthetic hexapeptide GHRP (examorelin; His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2), a super-analog of GHRP-6 that acts as a GHS-R1a agonist. trial
  • Mechanism: Sharp pituitary GH pulse via GHS-R1a; not fully GH-selective—documented concurrent rises in prolactin, ACTH, and cortisol at GH-effective doses. Synergizes with GHRH (separate receptor path). trial
  • Cardiac angle (research): Preclinical and some human-interest work on cardioprotection, ischemia-reperfusion, fibrosis, and CD36-mediated cardiac effects partly independent of GH—not a standard bodybuilding outcome claim. animaltrial
  • Evidence base: Substantial 1990s–2000s human IV/SC dose-response and chronic SC studies; developmental paths (including Phase II-era interest for GHD/heart failure) never produced a marketed drug. trial
  • What it is not: Not exogenous HGH, not a steroid/AAS, not MK-677 (oral non-peptide GHS), not Ipamorelin-level selective, not a local healing peptide (BPC/TB). trial

Stacks 9

  • CJC-1295 no-DAC (Mod GRF 1-29) + hexarelin: Classic GHRH + GHRP dual-pulse stack; community often pairs ~100 mcg Mod GRF with ~100–200 mcg hexarelin, 1–3×/day same timing. forum
  • Sermorelin + hexarelin: Older GHRH fragment pairing still discussed as a dual-path pulse stack. forum
  • Why GHRH + GHRP (not two GHRPs): Distinct receptors (GHRH-R vs GHS-R1a); literature and forums treat this as synergistic. Stacking hexarelin + GHRP-2 + GHRP-6 is widely called redundant (same receptor class) and spillover-additive. trialforum
  • Rotate / switch to Ipamorelin: Common when users want longer runs with less cortisol/prolactin or when hexarelin desensitization dominates. forum
  • Vs pure Ipamorelin stacks: Many long-term “GH optimization” logs prefer CJC no-DAC + Ipamorelin for selectivity; hexarelin reserved for shorter high-amplitude blocks. forum
  • BPC-157 / TB-500 (“Wolverine”) + GH axis: Occasional heal + secretagogue lifestyle stacks—outcomes confounded; no requirement to combine. forum
  • MK-677 (ibutamoren) overlap caution: Both hit GH secretagogue pathways; some advanced logs layer oral MK with injectables, others avoid stacking two strong GHS approaches due to side-effect load (hunger, water, insulin sensitivity talk)—not a hexarelin-specific trial protocol. forum
  • Avoid multi-GHRP blasts: Hexarelin + GHRP-2 and/or GHRP-6 same day often discouraged as little extra mechanism with more PRL/cortisol risk. forum
  • HGH comparison framing: Forums contrast pulsed secretagogue stacks vs exogenous rHGH for cost, detection lore, and physiologic pulse vs flat elevation—not a clinical substitution protocol. forum

Access talk 5

  • 2026 shelves: RUO vials and “strongest GHRP” marketing. Identity/fill risk is the same gray-market problem as other GHRPs. forum
  • Not on the July 2026 PCAC seven. trial
  • No 503A/503B compounding pathway in 2026 trackers — hexarelin is a research-chem GHRP, not a clinic bulk like sermorelin. trial
  • Not a heart drug: CD36 / cardioprotection papers are preclinical interest — not a compounding indication and not a self-experiment protocol. animal
  • WADA: GH secretagogues / GHRPs remain prohibited. trial

Labs people mention 5

  • IGF-1 is a weak hex scoreboard. Rahim’s chronic SC schedule found IGF-I largely unchanged even while GH pulses were still happening — 2026 threads that “check if hex works” with a single morning IGF-1 often read a nothing-burger. trialforum
  • If you lab at all: prolactin and (when someone is chasing mood/sleep) a cortisol-ish check get more hex-specific chatter than IGF-1. forum
  • Glucose: class GH-axis insulin-sensitivity talk, especially stacked with MK-677 or rGH. forum
  • If IGF-1 explodes: look for DAC-CJC, MK-677, or somatropin in the same month before crediting 100 mcg hex. forum
  • Don’t titrate to 200–300 ng/mL on hex alone — that sweet-spot lore is rGH/DAC talk. forum

Storage notes 2

  • No mix instructions here: STUDresearch does not list reconstitution, diluent volumes, or syringe unit charts. People reconstitute many different ways and vial labels differ — that content creates more confusion than clarity. forum
  • Storage (general talk only): Unopened research products are usually kept cool, dry, and away from light per the seller label. Anything after first use is product-specific — follow the label, not a universal forum SOP. forum

Watch for 19

  • Cortisol / ACTH: Dose-related rises at GH-effective doses in human IV studies; community brands hexarelin “dirtier” than Ipamorelin on HPA axis spillover. trialforum
  • Prolactin: Documented dose-dependent rises; forum concerns about libido, mood, or gynecomastia risk when PRL is elevated—monitor talk is common though not trial-mandated for gray-market use. trialforum
  • Water retention & edema-like feel: Fluid retention, puffiness, joint tightness reported in GHRP/GH-axis user logs. forum
  • Numbness / tingling: Extremity tingling or carpal-tunnel-like sensations discussed (GH-related lore). forum
  • Appetite / hunger: Increased hunger for some; generally framed as less extreme than GHRP-6. forum
  • Flush / headache / fatigue: Facial flushing, brief fatigue, headache after injections appear in user reports. forum
  • Injection site: Redness, sting, irritation, or lipodystrophy risk with repeated SC sites. forum
  • Sleep disruption (subset): Night dosing may worsen sleep for users sensitive to cortisol spillover—individual. forum
  • IGF-I / metabolic honesty: Chronic SC research schedule did not reliably raise IGF-I; glucose/insulin sensitivity concerns are general GH-axis cautions discussed in secretagogue communities. trialforum
  • Cardiac research ≠ safe self-use: Cardioprotective animal data and CD36 interest do not establish safety or benefit of unsupervised use; cardiovascular disease self-treatment is out of scope for research-chem forums. animalforum
  • Source quality: Mislabeling, underdosing, and impure gray-market vials are repeatedly flagged risks. forum
  • Not approved / research status: Not an FDA-approved therapy for body composition or anti-aging; forum protocols are not safety-validated clinical standards. forum
  • Drug / hormone interactions (discussion only): Stacking with other GHS, thyroid, or high-androgen cycles may compound side-effect monitoring complexity—community caution, not formal interaction labeling. forum
  • Cortisol / prolactin spillover: Still the “dirty GHRP” watch-for vs ipamorelin — sleep, libido, wired-tired. forum
  • Desensitization: Pulse fade by weeks 4–8 is expected in 2026 cycling talk; escalating mcg is the usual mistake. forum
  • Water / carpal / glucose: Same GH-axis triad when hex is stacked or run multi-daily. forum
  • Cardiac research ≠ gym safety: CD36 interest does not cancel spillover or gray-vial risk. forum
  • Desensitization / tachyphylaxis: Progressive attenuation of GH response with chronic/frequent use; human BID SC data support partial reversible blunting over weeks–months. Key practical downside vs selective GHRPs. trial
  • Population gaps: Much classic PK/PD is healthy adult men; elderly, short-stature pediatric, and disease-state papers exist but do not translate into consumer dosing rules. trial

Updated: 2026-09-01

Evidence mix Mostly community / anecdote tags Full: every bullet (trial + community). Use Scan for a faster bro-science read.

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