RGPU-95

RGPU-95 is discussed for calmer focus, mood and energy. Reports split between useful anxiety relief, unwanted emotional flattening and little noticeable effect. It is a chlorinated relative of phenylpiracetam; its name does not establish the same effects or timing.

What RGPU-95 is

• p-Cl-Phenylpiracetam is another name for RGPU-95. The AIPSIN identity record describes a synthetic phenylpiracetam derivative with chlorine attached to its phenyl ring. The “p-Cl” name describes this structural change; it is not shorthand for ordinary phenylpiracetam hydrochloride. Official context
• Cebaracetam is a separate identity. RGPU-95 has formula C12H13ClN2O2; PubChem lists Cebaracetam as C16H18ClN3O3. The different formulas make these separate compounds. Experiences under an uncertain label cannot settle which molecule was actually present. Official context Official context Personal report

Benefits people report

• Less anxiety with clearer focus. A recent commenter described better clarity, focus and mood at approximately 15 mg while also using stimulants. Another capsule user liked the calming effect. Those accounts do not isolate RGPU-95 from co-use or establish treatment of an anxiety disorder. Reddit
• More drive is possible, but far from consistent. A soccer player described energy and stamina after 30 mg. Other users described weak effects or no noticeable stimulation. The difference matters for someone expecting a reliable productivity boost. Personal report Reddit

Doses people discuss

mg means milligrams. These are attributed reports, not instructions or safety limits; missing routes and frequencies stay unspecified.

• About 15 mg: one report with stimulant co-use. The commenter did not specify route, formulation or frequency. This is one preferred amount, not a daily standard. Reddit
• 20–40 mg: one under-the-tongue report. The early author described sublingual use, with caffeine also in the account. An administration amount is not a daily total. Personal report
• 30 mg before soccer; around 40 mg in a separate calming report. The soccer user reported once-weekly use. The 40 mg commenter described benzodiazepine-like calm without fog. Neither supplied a route; these are separate experiences, not a dose ladder. Personal report Reddit

Half-life

• No verified human half-life was established. Neemio displays an estimated four-hour half-life in a clearance model. It supplies no matching human RGPU-95 measurement. A 2022 commenter instead suggests borrowing phenylpiracetam kinetics; that also lacks compound-specific evidence. Neither gives a dependable clearance time. Community guide Reddit

Onset: when people notice something

• 10–15 minutes in one sublingual account. That author placed the felt peak at 1–3 hours. These are subjective observations, not blood-concentration measurements. Personal report
• 30–60 minutes also circulates in a summary. Neemio displays this window without a route-specific firsthand log or human timing study supporting it. It should not be merged with the sublingual account into a universal range. Community guide

Duration: how long an effect feels present

• Still noticeable after six hours in the early report. This was not an exact stopping time or a half-life. Redosing and other substances complicate the later experience. Personal report
• The circulated 6–8-hour window is less firmly grounded. Neemio lists that duration, but the inspected evidence does not establish it as a typical response. A person who notices no effect has no measurable felt window to report. Community guide Reddit

Cycles and time off

• Occasional use and short daily experiments both appear. The soccer reporter used it once weekly and could not judge tolerance. The early author reported no perceived tolerance across seven days. Neither observation establishes a safe long-term pattern or reset interval. Personal report Personal report
• Four weeks on and one week off is a displayed claim, not a validated cycle. Neemio attributes this calendar to preventing receptor downregulation without a matching experiment. A recent capsule user simply preferred sparing use. There is no supported standard course in these accounts. Community guide Reddit

What can go wrong

• Calm can come with flattened mood and less energy. Black_Cat_Fujita described that combination after trying RGPU-95 during a phenylpiracetam shortage. A different 2021 reporter disliked its unpleasant energy. Anxiety relief and better functioning are not interchangeable outcomes. Reddit Reddit
• Headache, warmth, altered perception and a pull to redose were reported. The early author described these effects; the headache explanation involving choline was speculation. The same account included cannabis and caffeine, so attribution is uncertain. Personal report
• These reports do not establish interaction or long-term safety. Small, self-selected accounts cannot reveal how often problems occur. Stimulant combinations described as smoother are still combinations without controlled safety evidence here; neither a favorable forum report nor a research label verifies a product’s contents. Reddit Reddit Animal context

What the comparisons and disagreements add

• Phenylpiracetam comparisons point in opposite directions. In the 2022 discussion, one person found RGPU-95 indistinguishable from phenylpiracetam, while others found it weak or unstimulating. The soccer user’s 30 mg versus 120 mg comparison is personal, not a conversion formula. Reddit Personal report
• A fasoracetam comparison comes from a repeat reporter. Black_Cat_Fujita had already described nonstimulating, fasoracetam-like effects in January 2026 before the later flattened-mood comment. That is continuity from one handle, not two independent confirmations. Reddit Reddit
• Feeling better is not the same as improved memory. The early author found reading and tasks easier but no memory improvement by day seven. They had not tried phenylpiracetam, so their parent-compound comparison was secondhand. Personal report
• “Benzo-like” describes a feeling, not a proven mechanism. The 2021 calm-without-fog report does not establish benzodiazepine pharmacology. GABA and metabolic explanations circulate in the threads without receptor measurements, and one user’s response cannot establish a substitute for another drug. Reddit Reddit

What the animal research adds

• A rat study helps explain the anxiety interest. The 2010 abstract reports stronger anxiety-related behavioral effects than Fenotropil, weaker effects than diazepam, and differences between male and female rats. These are animal-test comparisons, not proof of anxiety relief or antidepressant efficacy in people. Animal context
• No human pharmacokinetic answer emerged from the inspected research. The rat abstract does not report human clearance, an effective human amount or long-term safety. This article’s practical numbers remain attributed experiences and circulated claims, with their limits intact. Animal context