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Selank

Also known as

TP-7 · Thr-Lys-Pro-Arg-Pro-Gly-Pro · TKPRPGP · Selanc · Селанк · Selank 0.15% (Russian nasal drops product form) · tuftsin-derived heptapeptide (research framing) · threonyl-lysyl-prolyl-arginyl-prolyl-glycyl-proline

Community talk. May be wrong. Not medical advice. Not a protocol. Not for human or animal use.

Open in the directory ↗
Peptide Lots of talk Systemic Nasal Cognitive / nootropic peptides

Systemic CNS framing — canonical route is intranasal for brain/anxiety endpoints, not local tissue repair.

What people say Selank is a Russian nasal-product peptide discussed for calm, rumination and focus under stress. The “benzo calm without fog” phrase is community shorthand, not medical equivalence.Plain Selank differs from Semax and N-acetyl/amidate Selank; their dose charts are not interchangeable. Doses people talk about
Community nasal daily totals~250–900 mcg intranasally in total per day, across 1–3 administrations

Forum band; concentration, actual device output and product identity vary.

Per-administration nasal talk~250–500 mcg intranasally per administration, once or twice daily

Other notes describe ~300 mcg two or three times daily. These are differing community patterns, not a progression.

Minority subcutaneous reports~200–500 mcg subcutaneously once daily

Separate lower-band talk quotes ~150–250 mcg/day, and some logs name ~400 mcg in the morning. These are forum conventions, not an equivalent nasal-label protocol.

These are reported amounts, not a recommended schedule. Research sprays, pharmacy drops and subcutaneous products are not interchangeable.

Half-life & effect duration

Half-life in the body
  • Parent peptide · lab breakdownAbout 2 minutes
Felt duration people report
  • Nasal calm · separate accountsAbout 30 minutes or about 3 hours
  • Other community duration estimatesAbout 3–6 hours
  • Other accountsLonger after under-the-skin use, or no noticeable effect
Timing context & sources
How it may feel Reports range from subtle calm and clearer thought to flatness, mild drowsiness, nasal irritation or no effect. Some describe an acute window; others notice a quieter baseline over a course.
Cycles people discuss Discussion includes roughly 10–21-day nasal courses, extensions to two to four weeks, and days-to-weeks off. As-needed situational use also appears; these calendars are not a PK-derived rule. Timing Daytime and situational use feature prominently, sometimes with Semax earlier and Selank later. Evening accounts can describe calm, flatness or next-day dullness; felt wear-off does not establish parent clearance. Stacks Semax + Selank (dominant pair): “Focus stack” / “calm focus” — Semax for activating attention, Selank for anxiolysis. Often same course length and both nasal. Ratio talk is usually independent full doses of each, not a fixed mg:mg blend. Access talk How people talk about getting it: Imported Russian drops or gray-market research sprays/vials — identity and concentration are trust-the-label problems. Watch for Nasal irritation (most common): Burning, dryness, sneezing, runny nose, post-nasal drip / throat taste when solution runs posteriorly.
Related
SemaxNoopeptDSIPPE-22-28Pinealon

Tap a line to jump into the full notes. Research only — may be wrong.

Timing context & sources

Half-life in the body

Rapid plasma decline; a precise human half-life was not verified.

The nasal-drop leaflet describes falling plasma concentrations over 5–5.5 minutes. It does not call that an elimination half-life.

The leaflet gives no study sample or assay here. The original labelled-peptide abstract also supplies no numeric human half-life. Neither establishes kinetics for injections or N-acetyl/amidate variants.

Felt duration people report

Nasal calm is described as roughly half an hour to about three hours in two accounts. One reports longer after SubQ use; others feel nothing.

These are different people's experiences, not a measured range or proof that one route works better.

ELROCK's nasal account reports at most about three hours and later purity concerns. Old-Yogurtcloset-738 contrasts about half an hour nasally with over four hours SubQ. A deleted-name commenter reports no effect. Product identity, co-use and causal effects are not verified; adjacent modified-variant reports are not borrowed.

What people say 13

  • Anxiolytic (primary hook): Lower baseline anxiety, rumination, and edge without heavy benzo-style sedation or memory fog — the core community claim. forum
  • Clarity after anxiety drops: Clearer thinking once “noise” falls — mixed attribution (true nootropic vs secondary to anxiolysis). forum
  • Mood / stress course effect: Steadier multi-day stress handling more than a single-dose buzz or euphoria. anecdote
  • Vs Semax typology: Community shorthand — Selank = calm / anxiolytic; Semax = activating / focus. Useful for stacking talk, not a pivotal head-to-head Western RCT. forum
  • Stack halo warning: Semax+Selank, caffeine, racetams, sleep changes often co-occur — single-agent credit is unreliable. forum
  • Brain fog (secondary): Some describe clearer thinking once rumination drops; others call it flat, not sharper. Fog-lift is not the lead claim. forum
  • Calm under load: Social, work, travel, exam, or high-demand stress — composure and “still able to work” framing more than sedation. forum
  • Russian GAD / neurasthenia: Zozulia et al. 2008 (PMID 18454096) compared Selank (n=30) vs medazepam (n=32) in GAD/neurasthenia; anxiolytic effects described as similar on standard anxiety scales, with Selank also showing antiasthenic / mild psychostimulant properties the benzo arm lacked, and leu-enkephalin changes correlating with improvement in the Selank group. trial
  • Non-sedating / non-dependence narrative: Russian clinical summaries repeatedly claim anxiolysis without amnesia, muscle relaxation, tolerance, or withdrawal typical of classical benzodiazepines — this is the marketing and forum refrain; long-term Western self-use safety is not proven by that claim. trial
  • Learning / memory (preclinical + Russian summaries): Rodent learning/memory optimization and BDNF hippocampal expression after intranasal Selank (e.g. Inozemtseva et al., PMID 18841804); forums recycle as focus/study support. animal
  • Enkephalin / endogenous peptide angle: Selank (and Semax) inhibit serum enkephalin-degrading enzymes in lab work — used to explain calm without opioid sedation. trial
  • Vs benzos (user language): “Takes the edge off without destroying drive or next-day fog” — anecdotal comparison only; not medical equivalence. anecdote
  • Immune / cytokine (secondary): Immunomodulatory discussion (IL-6, T-helper balance) in Russian product/clinical framing; less central in Western anxiety-focused threads. trial

Doses people talk about 14

  • Community nasal daily total (most common Western forum band): ~250–900 mcg/day total, usually split 1–3×. forum
  • Lower nasal amount discussed: Some charts describe ~200–300 mcg/day, sometimes as a single administration, for tolerance and “is any calm felt?” checks. This is reported experimentation, not a recommended starting band. forum
  • Common working band: ~250–500 mcg per administration, 1–2× daily; or ~300 mcg × 2–3× daily when mirroring Russian multi-dose cadence. forum
  • Higher community / protocol-chart band: Toward ~600–1,200+ mcg/day split, sometimes framed for “stronger anxiety load” — still not a trial-proven ladder. forum
  • Per spray / per drop uncertainty: Metered research sprays often marketed ~100–300 mcg/actuation depending on dilution; Russian drop math often assumes ~75 mcg/drop in secondary sources — DIY mcg/spray is dilution- and device-dependent and is a frequent error source. forum
  • Injectable “0.5 mg” charts: Some commercial guides list ~0.5 mg injectable as a “standard” — that sits high vs many forum SC logs and should be treated as vendor chart noise unless tied to a specific study. forum
  • Timing: Anytime for pure calm goals; some prefer morning or daytime so any mild fatigue is not layered on sleep debt. Unlike Semax, evening Selank is less consistently flagged for insomnia — but individual reports of flatness or next-day dullness exist. forum
  • As-needed vs scheduled: High-stress days only (acute) vs daily through a fixed 10–21 day course then stop — both patterns are common. Single daily dosing is often described as leaving gaps if the goal is all-day coverage. forum
  • Uncertainty / quality: Fill errors, underdosed sprays, wrong analog (plain vs N-acetyl amidate), and dead volume on spray bottles make labeled mcg ≠ delivered mcg. forum
  • SubQ (minority; not the labeled clinical route): Starting talk often ~150–250 mcg/day SC; common “standard” forum band ~200–500 mcg/day SC once daily; some logs cite ~400 mcg SC morning. No published human injection protocol equivalent to the nasal label was identified in careful secondary reviews — SubQ dosing is research-chem/forum convention. forum
  • 2026 nasal vs SubQ camps: Nasal is the labeled/clinical route (hundreds of mcg, often split). SubQ camp uses lower mcg — often ~150–300 mcg once daily, some logs ~200–500 mcg SC — arguing better systemic exposure and no spray-technique lottery. Still research-chem convention, not a published human injection protocol. forum
  • Framing: Community and secondary-source research-discussion ranges only — not medical advice, not prescriptions, not validated Western protocols. Gray-market mcg labels are not pharmacy-grade identity. forum
  • Nasal vs SubQ dose relationship (bro lore): Injection often discussed at lower mcg than nasal because of assumed higher systemic bioavailability; nasal still preferred for “CNS / nose-to-brain” framing and for matching the studied route. Bioavailability percentages circulating on vendor blogs are not primary PK citations. forum
  • Russian / clinical secondary bands: Multi-week courses in secondary summaries often cite ~600–2,700 mcg/day split 2–3× nasal; also “~300 mcg per administration × 3/day (~900 mcg/day)” as a common label-derived simplification. Upper-end figures are not independently verified Western standards. trial

How it may feel 10

  • Minutes–hours 1–3 (acute nasal): Subjective onset often described ~15–60 minutes (sometimes “tens of minutes to a few hours”); subtle calm, reduced social edge, or nothing noticeable day one. Not a recreational buzz. forum
  • Same-day duration talk: Per-dose subjective coverage often framed ~3–6 hours for some users → multi-dose daily schedules; others describe quieter baseline shift more than discrete “kicks.” forum
  • Days 1–3: Early anxiety drop for responders; nasal irritation, post-nasal drip, or mild headache often noticed before mood claims. Some report first-dose oddities (HR, flush) then settle. forum
  • Days 3–7: Common first “is this working?” checkpoint — less baseline rumination, easier high-stress days, still no euphoria expected. forum
  • Weeks 2–3 / extended community courses: Some continue toward ~21 days or ~2–4 weeks; plateau, flatness, or “already got what I needed” are common stop reasons. forum
  • End of course / washout: Many stop on a fixed calendar; residual calm can linger days for some; others fade quickly. Standard community off-period talk is days–weeks (often roughly matching time-on). anecdote
  • No change by ~10–14 days: Forum replies question product authenticity, spray concentration math, sleep, caffeine and expectations when no effect is noticed. These are unverified explanations, not validated troubleshooting or a reason for automatic dose-stacking. forum
  • Not a stim: Unlike Semax, evening Selank is less often blamed for insomnia; the louder complaint is “too calm / unmotivated,” especially at higher mcg or stacked with other calm agents. forum
  • Social / performance window: Situational calm 30–60 minutes after a nasal dose is a common as-needed story — subtle, not a benzo knockout. forum
  • Week 1–2 (Russian-style course window): Mid-course reassessment for cumulative stress resilience; 10–14 day blocks mirror labeled Russian course length talk. trial

Around the dose 5

  • Clock: Daytime when anxiety/focus is the job; some use it later if Semax was too sharp. forum
  • Habits: Breathing / not stacking more stims. Selank as a night knockout is not the main chart. forum
  • With Semax: Semax earlier, Selank later (or both split) is the common 2025–2026 clock so the calm half does not flatten the morning. forum
  • As-needed vs course: High-anxiety days only vs a 10–21 day nasal course — both patterns stay loud. forum
  • Avoid: Adding extra alcohol or benzos “because it isn’t a benzo” is a recurring harm-reduction warning. forum

Cycles people discuss 9

  • Community extension: ~14–21 days frequently; some protocol blogs extend to ~2–4 weeks or cite ~30-day frameworks — longer courses have thinner formal study support. forum
  • Short vs long: Cycles shorter than ~7 days sometimes called “incomplete” for cumulative gene/BDNF-style effects in secondary writeups; continuous multi-month daily use is less common in careful logs. forum
  • Time off: Days to a few weeks between courses is standard forum practice; some secondary Russian-product language mentions repeat after ~1–3 weeks if needed, or less frequent re-courses (e.g. multi-month spacing) depending on source. forum
  • On/off symmetry talk: “2–4 weeks on, 2–4 weeks off” appears in community protocol pages as a convenience pattern, not a hard PK rule. forum
  • As-needed pulse: Acute high-anxiety days or situational social/performance use without a full multi-week course — reported, especially after someone knows their response. anecdote
  • With Semax / NA-Semax: Usually same calendar block (both on together), not staggered multi-week cycles. forum
  • Re-runs: Before travel, exams, launches, or high-demand work; continuous open-ended daily use is less the default than for some other peptides. forum
  • Tolerance talk: No classic benzo-withdrawal narrative in community; whether subtle blunting develops with long continuous use is unsettled and sparsely logged. forum
  • Classic Russian-style course: ~10–14 days nasal, matching labeled product course language and the common clinical summary length. trial

Timing 9

  • Parent-peptide blood kinetics: Older secondary summaries quote a ~2-minute half-life and intact peptide becoming undetectable within ~10 minutes; those figures are not verified here as human elimination measurements. The 0.15% nasal manufacturer leaflet describes a plasma decline over 5–5.5 minutes without calling it an elimination half-life. The labelled-peptide abstract describes degradation but supplies no numeric human half-life. Multi-dose schedules remain reported practice, not intervals established by these figures. trialforum
  • Downstream-effect explanations: GABA modulation talk, enkephalin pathways and gene-expression/BDNF changes in animals are used to explain reported hours-to-days functional effects after brief exposure. These proposed explanations do not establish measured human parent clearance or a reliable duration for every user. animalforum
  • Subjective onset: Often ~15–60 minutes nasal (anecdote; not controlled human PK). anecdote
  • Subjective per-dose window: Some accounts describe a few hours of noticeable calm and use that impression to explain 2–3× daily schedules; others describe a quieter baseline building over days of a course. This is community timing rationale, not a measured clearance-derived dosing interval. forum
  • Split dosing rationale: Afternoon wear-off after morning-only dosing is a common reason for AM/PM or 2–3× schedules. forum
  • Course vs acute: Acute situational calm vs multi-day “stress resilience” after repeated administrations — both claimed; second is closer to how Russian courses are framed. forum
  • N-Acetyl / Amidate contrast: Modified Selank sold for longer stability and less frequent dosing in theory; plain Selank remains the molecule with clinical Russian history. Do not copy NA-Selank Amidate dose charts 1:1 onto plain Selank. forum
  • Animal timing endpoints: Rodent brain gene/BDNF work often samples ~1–3 hours post-intranasal — supports CNS engagement talk, not a human dosing clock. animal
  • Why nasal not oral: Oral peptide framed as unstable / poor CNS delivery; intranasal is the registered and preferred research route for CNS goals. trial

More on what it is 9

  • Why people search it: One of the top “calming peptide” names in biohacking; Russian pharmacy/product history + “benzo calm without fog/dependence” marketing hook; almost always paired in talk with Semax. forum
  • 2026 size/route talk: Selank is a small heptapeptide (~751 Da). 2025–2026 absorption charts put it next to Semax in the “built for the nose” bucket (olfactory/trigeminal / nose-to-brain), not as a large-peptide spray. forum
  • What it is: Synthetic heptapeptide Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP); tuftsin (Thr-Lys-Pro-Arg) elongated with C-terminal Pro-Gly-Pro for metabolic stability. Developed at Institute of Molecular Genetics, Russian Academy of Sciences (with Zakusov Institute pharmacology work). trial
  • Mechanism talk (simplified online): GABA-A allosteric modulation (benzo-adjacent spectrum without classic benzo side-effect package in Russian summaries), enkephalinase inhibition / leu-enkephalin support, monoamine and serotonin metabolism shifts, hippocampal BDNF elevation (rodent), and secondary immune/cytokine (IL-6, T-helper balance) narratives from tuftsin lineage. Forums compress this to “GABA + stress peptides + BDNF.” trial
  • Evidence honesty: Russian GAD/neurasthenia clinical work and registered 0.15% nasal product denser than most gray peptides; English-indexed controlled literature is small and geographically concentrated; few independent Western RCTs; ClinicalTrials.gov has essentially no Selank intervention program in the usual Western sense. trial
  • Not: Not a benzodiazepine, not a hypnotic, not FDA- or EMA-approved, not the same molecule as N-Acetyl-Selank Amidate, not interchangeable dose-for-dose with Semax. trial
  • Lens: Vendor dose charts, “Xanax without fog,” and SubQ protocols are discussion/commerce data — not prescriptions. Gray-market spray identity ≠ Russian pharmacy Selank. forum
  • Russian product PK language: Registered 0.15% nasal materials cite ~92.8% absolute bioavailability after nasal administration, with plasma detection in tens of seconds and a rapid fall over minutes. That is product-insert PK language, not an independent Western PK trial. trial
  • Not on the July 2026 PCAC seven: Semax was reviewed that week; Selank was not. Emideltide is a DSIP name — not Selank. trial

Stacks 12

  • Semax + Selank (dominant pair): “Focus stack” / “calm focus” — Semax for activating attention, Selank for anxiolysis. Often same course length and both nasal. Ratio talk is usually independent full doses of each, not a fixed mg:mg blend. forum
  • NA-Semax Amidate + Selank or NA-Selank Amidate: Same typology with modified analogs when users want longer perceived duration or different spray stock. forum
  • Timing within the pair: Some run Semax-class earlier in the day and Selank later (or both multi-dose); others dose together. Not standardized. forum
  • Noopept + Selank: Occasional memory/focus + anxiety-control pairing in older nootropic stacks. forum
  • Caffeine / L-theanine layer: Common lifestyle stack; watch overstimulation if Semax is also present. forum
  • Racetams / other nootropics: Piracetam, phenylpiracetam, etc. in legacy stacks — confounds attribution. forum
  • Dihexa / P21 / other cognitive peptides: Mentioned in aggressive nootropic stacks; sparse controlled data and hard to isolate effects. forum
  • DSIP / sleep agents: Sometimes discussed when anxiety and sleep interact; separate goals. forum
  • Stimulant meds (e.g. ADHD Rx): Harm-reduction threads ask about stacking with prescribed stimulants; no solid interaction tables — confounded and not evidence-based. forum
  • Lifestyle co-credit: Sleep, caffeine reduction, therapy, and load management often co-credited with “Selank worked.” forum
  • Avoid double-calm stacking blindly: Multiple anxiolytics + high Selank → flat / unmotivated reports in anecdotes. anecdote
  • Combo Semax+Selank bottles: Telehealth/research sprays sometimes mix both in one bottle — two peptides, one actuation, messy credit. forum

Access talk 3

  • How people talk about getting it: Imported Russian drops or gray-market research sprays/vials — identity and concentration are trust-the-label problems. forum
  • U.S. compounding: 503A nomination withdrawn (Selank acetate / TP-7). Not on the July 2026 PCAC panel that reviewed Semax. No current 503A bulks-list listing. trial
  • Russian 0.15% nasal pharmacy product is the labeled history (GAD/neurasthenia framing). trial

Storage notes 2

  • No mix instructions here: STUDresearch does not list reconstitution, diluent volumes, or syringe unit charts. People reconstitute many different ways and vial labels differ — that content creates more confusion than clarity. forum
  • Storage (general talk only): Unopened research products are usually kept cool, dry, and away from light per the seller label. Anything after first use is product-specific — follow the label, not a universal forum SOP. forum

Watch for 15

  • Nasal irritation (most common): Burning, dryness, sneezing, runny nose, post-nasal drip / throat taste when solution runs posteriorly. forum
  • Headache / sinus pressure: Mild head pressure or tension-type headache — sometimes days 3–5 into a course; often blamed on spray technique, dehydration, or Semax co-use. forum
  • Fatigue / mild sedation: “Too calm,” flat motivation, or mild drowsiness especially at higher discussed amounts or when stacked with other calming agents — not classic benzo knock-out for most reporters. forum
  • Cognitive dulling / depression-like flatness: Minority reports of sedation, cognitive impairment, or low mood — sometimes when stacked aggressively. anecdote
  • Paradox / first-dose oddities: Rare logs of nausea, hot/cold flashes, elevated heart rate, or anxiety spike after first nasal exposure (sometimes with drip-down); usually discussed as one-off or technique-related, not a universal pattern. anecdote
  • Overstimulation / irritability: Less common than with Semax; occasionally reported at higher doses or in sensitive users. forum
  • Injection-site issues (if SubQ): Redness, irritation, or typical peptide pin discomfort. forum
  • Source / identity risk: Mislabel (wrong peptide or plain vs N-acetyl amidate), underfilled vials, unknown concentration, bacterial contamination of multi-use sprays. forum
  • Regulatory: Russian registration of a 0.15% nasal product ≠ FDA/EMA approval; US compounding status has been restricted/unclear historically (Category 2 nomination history / withdrawn nomination — not an authorization). Research-chem sales elsewhere are not pharmacy therapy. forum
  • Dependence narrative gap: Community and Russian summaries emphasize lack of classic benzo withdrawal — that is not the same as proven long-term self-experimentation safety or zero rebound anxiety after stopping a course. forum
  • Not risk-free: “Well tolerated in short Russian courses” does not make uncontrolled use risk-free, especially with unknown purity. forum
  • Analog mix-up: Plain Selank ≠ N-Acetyl Selank ≠ N-Acetyl Selank Amidate. Labels and logs blur these; mcg charts do not copy 1:1. forum
  • Interactions: No robust public interaction tables for SSRIs, SNRIs, benzos, alcohol, stimulants, or other peptides. Animal work has explored Selank with diazepam (combination pharmacology) — not a human polypharmacy guide. trial
  • Evidence limits: Small, mostly Russian clinical base; English abstracts often thin on exact dose/route details; healthy-enhancement and long-term gray-market use lack Western-grade safety databases. trial
  • Access / compounding: Selank acetate (TP-7) had its 503A Category 2 nomination withdrawn (removed from Category 2 in Sept 2024 by withdrawn nomination). It was not on the July 2026 PCAC seven. No 503A bulks-list listing. Russian Rx ≠ U.S. compounding clearance. trial

Updated: 2026-09-01

Evidence mix Mostly community / anecdote tags Full: every bullet (trial + community). Use Scan for a faster bro-science read.
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