Non-peptide

Tesofensine

Also known as

NS2330 · NS-2330 · NS 2330 · Tesofensine hydrochloride · Tesofensine HCl · Tesofensine citrate (research-salt discussions) · phenyltropane triple reuptake inhibitor (class talk)

Community talk. May contain inaccuracies. Not medical advice. Not a protocol. Not for human or animal use.

What it is

Identity	An oral small molecule, also called NS2330, discussed for quieter food cravings and weight loss. It slows reuptake of serotonin, norepinephrine and dopamine.
Forms	Most accounts concern swallowed capsules or tablets. Liquids, powders and under-the-tongue reports do not establish equivalent absorption; it is not a peptide.

Notes

Tesofensine is an oral small molecule people discuss for quieter food cravings and easier weight loss. It is not a peptide. Some describe smaller meals and more energy; others remain hungry, feel flat or stop because sleep and heart-rate effects outweigh the benefit.

It changes brain signaling involved in appetite. Also called NS2330, it slows the reuptake of serotonin, norepinephrine and dopamine. That means those signals remain available longer. Its mechanism differs from GLP-1 drugs, even when communities compare their weight-loss effects. Astrup et al. 2008 obesity trial — PubMed abstract and linked expression of concern (Official context · Accessed 2026-09-30)

Most accounts concern swallowed capsules or tablets. Liquids, powders and occasional sublingual reports also appear; the latter means held under the tongue. Those forms do not establish equivalent absorption. Placement on a peptide seller's shelf does not turn it into an injectable peptide. any experience with TESOFENSINE? (Community discussion · Accessed 2026-09-30)

Source context — Astrup et al. 2008 obesity trial — PubMed abstract and linked expression of concern: Abstract and bibliographic concern link only; primary full text and full expression-of-concern notice not reviewed. Do not infer the reason for the concern or claim resolution/retraction. Historical diet-supported trial, not modern GLP-1 comparison or gray-market validation.

Source context — any experience with TESOFENSINE?: Forum with supplier advertising; unverified products and doses absent. The user's metabolism explanation is subjective. Weight changes cannot be attributed to tesofensine from this account.

What people notice

Food and cravings	Some describe smaller satisfying meals, less snacking and reduced sugar or alcohol cravings. Others remain hungry despite mental effects.
Energy and focus	Some like the motivation or clearer thinking; others become tired or emotionally flat. Feeling mentally different does not demonstrate weight loss.
Mixed tracking results	Diary improvements in sleep or heart-rate variability coexist with flat energy and higher pulse reports; medication changes and other compounds differ across accounts.

Notes

Less snacking and less attention on food. One two-week account described smaller lunches and reduced sugar and alcohol cravings. Another described satisfying small meals rather than complete appetite loss. These are individual experiences, not evidence that it treats alcohol dependence. 2 week tesofensine experience (Community discussion · Accessed 2026-09-30) · My experience so far (Community discussion · Accessed 2026-09-30)

Energy or focus can improve without appetite improving. Users sometimes like the motivation or clearer thinking while still feeling hungry. Others become tired or emotionally flat. A noticeable mental effect is not proof of weight loss or an established ADHD or depression treatment. Tesofensine — appetite nonresponse after GLP-1 use (Community discussion · Accessed 2026-09-30) · Any experiences with tesofensine? (Community discussion · Accessed 2026-09-30) · My experience so far (Community discussion · Accessed 2026-09-30)

No appetite change after two weeks or a month also appears. BodyHackGuide includes a two-week nonresponse at 500 mcg. A Peptides author remained hungry after over a month despite mood and sleep changes. Waiting longer does not guarantee a response; early sleep disturbance can arrive before any appetite benefit. Tesofensine — rapid escalation and unpleasant effects (Community discussion · Accessed 2026-09-30) · Tesofensine — appetite nonresponse after GLP-1 use (Community discussion · Accessed 2026-09-30) · Any experiences with tesofensine? (Community discussion · Accessed 2026-09-30)

Tracker improvements coexist with flat energy and higher pulse reports. A diary described improved Oura HRV and sleep during medication changes; a commenter reported lower resting pulse but later less energy and appetite benefit. Another described getting tired and flat. Existing reports include resting pulse about 10 bpm higher; none is a controlled comparison. My experience so far (Community discussion · Accessed 2026-09-30)

Source context — 2 week tesofensine experience: Self-reports with unverified products and changing diet/other compounds. Calculator estimates are not measured concentrations. Only loaded replies were inspected; no claim to all collapsed replies. Individual endpoints are not controlled outcomes.

Source context — My experience so far: Wellbutrin stopped and sermorelin started alongside tesofensine in the opening diary. The later 0.50 daily/retatrutide account is displayed under Sunflwrgirl, not the opening author's username, so no same-author longitudinal assumption is made. Autoimmune symptoms and cycle phase also confound reports. Relative dates not converted.

Source context — Tesofensine — appetite nonresponse after GLP-1 use: Unverified anecdotes, not incidence estimates or causal diagnoses. Gastroparesis and tinnitus attributions are personal reports. The article does not adopt replies' supplier advice, metabolic-rate certainty or claim that tirzepatide universally has fewer adverse effects.

Source context — Any experiences with tesofensine?: Unknown product identity and co-medications; one contributor later advertises white-labeled products, so that contributor's favorable morning/1 mg story is not used as independent reassurance. Other accounts remain anecdotes. '500mg' is not silently corrected or used as a dose value.

Source context — Tesofensine — rapid escalation and unpleasant effects: Small, self-selected sample; some usernames deleted. The severe-effects post does not identify each symptom. Prescriptive replies and predictions are not endorsed. The 8-on/4-off text is only an unanswered question in the inspected portion.

Doses people talk about

Daily oral reports	250–500 mcg (0.25–0.5 mg) once daily recurs. Charts discuss 1–4 weeks at 250 mcg before 500 mcg; individual diaries vary and do not establish a safe titration.
Skip-day and higher reports	Separate accounts describe 125 mcg or 500 mcg every other day. Another reports increasing 500 mcg to 1 mg, followed by three difficult days.
Unclear units	Some posts print “500mg” or “25mg” without clarification; these figures are too unclear to treat as confirmed amounts.

Notes

250–500 mcg (0.25–0.5 mg) once daily. These recur in reviewed accounts. Existing charts describe holding 250 mcg for 1–4 weeks before 500 mcg; one diary instead changed after two days. Neither establishes a safe titration schedule. 2 week tesofensine experience (Community discussion · Accessed 2026-09-30) · My experience so far (Community discussion · Accessed 2026-09-30)

Skip-day amounts and 1 mg reports are separate patterns. A NooTopics commenter reported 125 mcg every other day; a BodyHackGuide poster reported 500 mcg every other day after an unpleasant increase. That thread also contains a 500 mcg-to-1 mg escalation followed by three difficult days. These are not interchangeable daily totals. Any experiences with tesofensine? (Community discussion · Accessed 2026-09-30) · Tesofensine — rapid escalation and unpleasant effects (Community discussion · Accessed 2026-09-30)

Units and product identity remain practical uncertainties. Capsule, powder and dropper labels are not verified exposure. The NooTopics thread contains a '500mg' entry and AnabolicMinds contains '25mg'; neither author clarifies the unit. Those entries are excluded from the dose picture rather than silently repaired to micrograms. Any experiences with tesofensine? (Community discussion · Accessed 2026-09-30) · Tesofensine (NS2330) (Community discussion · Accessed 2026-09-30)

Source context — Tesofensine (NS2330): Informal physiology explanations are opinions. AwakeningAlpha's 'I think 25mg' is unresolved and not a dose anchor. No finished weight-loss log; advertising and supplement culture surround the forum.

Half-life, onset & duration

Felt onset	Appetite changes appear within 1–2 days, days 8–14 or around day 10 in different accounts. No appetite change after two weeks or over a month also appears.
Felt duration	No dependable single-dose appetite window emerges. One person said hunger returned two days after a four-month run; another reported two stretches of 48 hours awake as an adverse effect.
Half-life	A human clinical protocol reports about 220 hours (nine days) for tesofensine and 374 hours (16 days) for its metabolite NS2360. These are separate clearance clocks, not felt duration.
Build-up and timing	Weeks-to-build-up claims differ from felt onset. Early-day use is discussed for sleep, but morning use or skipping a dose does not remove lingering exposure.

Notes

Appetite reports range from 1–2 days to the second week. One 500 mcg account described a day-or-two response. A 250 mcg daily log noticed its biggest changes on days 8–14. Another diary placed appetite changes around day 10, but had also stopped Wellbutrin and started sermorelin. Tesofensine — appetite nonresponse after GLP-1 use (Community discussion · Accessed 2026-09-30) · 2 week tesofensine experience (Community discussion · Accessed 2026-09-30) · My experience so far (Community discussion · Accessed 2026-09-30)

There is no dependable single-dose appetite window. The reports describe repeated use. One commenter said hunger returned two days after stopping a four-month run; another said early appetite quiet faded during continued use. Those experiences do not measure elimination or predict anyone else's rebound. 2 week tesofensine experience (Community discussion · Accessed 2026-09-30) · My experience so far (Community discussion · Accessed 2026-09-30)

Feeling alert can outlast a normal sleep period. One 500 mcg poster reported two stretches of 48 hours awake. A reply described fragmented sleep; another described better sleep timing. Forty-eight hours is that person's adverse experience, not a typical benefit duration or evidence of less need for sleep. Lack of need for sleep (Community discussion · Accessed 2026-09-30)

Human kinetics distinguish parent drug from metabolite. A Saniona protocol summarizes about 220 hours (9 days) for tesofensine and 374 hours (16 days) for NS2360, its metabolite. These are clinical-program measurements, not felt-duration clocks. Food did not materially change relative bioavailability in that summary. Saniona TM003 Tesomet clinical study protocol (Official context · Accessed 2026-09-30)

Weeks to build up is a different question from onset. Existing guides circulate 4–6 weeks, sometimes about 8 weeks, for levels to stabilize, with multi-week or 1–2 month clearance estimates. These are informal planning claims, not personal clearance measurements or drug-test windows.

Dry-mouth tricks and self-monitoring are part of the practical talk. Water, sugar-free gum, early-day timing, a home BP cuff and sleep/mood logs recur. Resting-pulse thresholds around 90 bpm or 10–15 above baseline are informal heuristics, not safe limits. These observations also are not a blood test proving benefit.

Sleep, pulse, mood and digestion can change together. Reports include insomnia, dry mouth, constipation, headache, restlessness, anxiety and flat or depressed mood. One user reported erectile difficulty and sweating; another reported tinnitus persisting after stopping. Those individual accounts cannot establish causation or frequency. Morning use does not guarantee undisturbed sleep. Any experiences with tesofensine? (Community discussion · Accessed 2026-09-30) · Tesofensine — appetite nonresponse after GLP-1 use (Community discussion · Accessed 2026-09-30) · Lack of need for sleep (Community discussion · Accessed 2026-09-30)

A skipped dose does not remove accumulated exposure. Long elimination makes lingering effects a concern. The published trial reported a 7.4 bpm heart-rate increase at 0.5 mg. A reassuring watch score or a good first week cannot establish cardiovascular safety. Saniona TM003 Tesomet clinical study protocol (Official context · Accessed 2026-09-30) · Astrup et al. 2008 obesity trial — PubMed abstract and linked expression of concern (Official context · Accessed 2026-09-30) · My experience so far (Community discussion · Accessed 2026-09-30)

Source context — Lack of need for sleep: Three unverified reports; no assessed sleep requirement, objective cognitive safety, product test or visible outcome follow-up. The poster's feeling fine is not evidence that sleep deprivation is harmless. Previously linked record reopened rather than counted as new independent evidence.

Source context — Saniona TM003 Tesomet clinical study protocol: Sponsor summary of earlier PK, not underlying concentration-time datasets. TM003 uses metoprolol-containing formulations; its studied doses cannot be substituted for a plain-community tesofensine regimen. Kinetics do not establish appetite, sleep or adverse-effect duration.

Cycles people discuss

Reported blocks	8–12 or 16–24-week blocks, seasonal reuse and 4–8+ week breaks appear. Reviewed accounts include a four-month run and unspecified on/off use over two years.
Breaks and reset claims	A couple of days off is not a full washout. No shared optimal cycle or proven tolerance reset emerges; an eight-on/four-off question was not a completed practice.

Notes

Existing discussions describe 8–12 or 16–24 week blocks. They also contain multi-month or seasonal reuse and 4–8+ week breaks. Reviewed examples include a four-month run followed by a break and two years of unspecified on/off use. No shared optimal cycle or proven tolerance reset emerges. 2 week tesofensine experience (Community discussion · Accessed 2026-09-30) · Tesofensine — rapid escalation and unpleasant effects (Community discussion · Accessed 2026-09-30)

A couple of days off is not a full washout. Posters skip days because of tiredness, appetite preferences or sleep disruption; the existing record notes disagreement about irregular intake. Continuous clinical treatment and these informal patterns answer different questions. The 8-weeks-on/4-off question in BodyHackGuide is a question, not a verified practice. My experience so far (Community discussion · Accessed 2026-09-30) · Lack of need for sleep (Community discussion · Accessed 2026-09-30) · Tesofensine — rapid escalation and unpleasant effects (Community discussion · Accessed 2026-09-30)

Stacks

GLP-1 add-ons	Accounts combine it with tirzepatide or later retatrutide; older talk includes semaglutide for residual hunger or fatigue. The reports do not establish synergy or safety.
Stimulants and other add-ons	Caffeine, yohimbine, Cardarine, 5-Amino-1MQ, AOD-9604 and HGH fragments appear in discussions. Extra stimulant effects and sleep trouble are concerns.
Tesomet and shop blends	Tesomet's studied 0.5 mg tesofensine/50 mg metoprolol combination is separate from seller blends with magnesium L-threonate and taurine. The seller blends have no component amounts recorded here.
Habits and monitoring	Diet, protein and activity accompany some outcomes; home blood-pressure, sleep and mood logs recur in practical talk.

Notes

GLP-1 add-ons are discussed for residual hunger or fatigue. Reviewed accounts combine tesofensine with tirzepatide or later retatrutide. Other existing stack talk names semaglutide, Cardarine, 5-Amino-1MQ, AOD-9604 and HGH fragments. Diet and multiple compounds obscure credit; these reports do not establish synergy or combination safety. 2 week tesofensine experience (Community discussion · Accessed 2026-09-30) · My experience so far (Community discussion · Accessed 2026-09-30)

GLP-1 / dual / triple agonists: Semaglutide, tirzepatide, retatrutide — sequential or overlapping use is heavily discussed: teso for central food-noise, GLP-1 for peripheral satiety/gastric emptying. No controlled synergy RCTs; additive nausea/HR/sleep risk is the counter-argument. [community]

Sema fatigue rescue narrative: Anecdotes of adding low-dose teso when GLP-1 fatigue or residual hunger remains — confounded and unsupervised in research-chem contexts. [anecdote]

Extra stimulants and medication changes complicate the picture. Forum users discuss stronger pre-workout effects and trouble sleeping with caffeine or yohimbine. Existing cautions also flag serotonergic drugs and MAOIs. Supplement sleep stacks, beta-blockers or a seller's reassuring copy do not establish a safe combination. Tesofensine (NS2330) (Community discussion · Accessed 2026-09-30)

Plain Tesofensine, Tesomet and shop blends are different products. The existing record describes Tesomet as tesofensine plus metoprolol, including a studied 0.5 mg/50 mg combination. BioFlow-style seller blends instead add magnesium L-threonate and taurine, with no component amounts recorded here. Their 'sides cover' pitch does not prove protection or equivalence to Tesomet.

Diet first: Structured calorie deficit + protein + steps/cardio is credited whenever community outcomes look trial-like; TIPO-1 co-prescribed energy restriction. [trial] [community]

Watch for

Sleep, mood and digestion	Reports include insomnia, dry mouth, constipation, headache, anxiety, flat/depressed mood, sweating, erectile difficulty and persistent tinnitus in one account.
Pulse and lingering effects	The published trial reported a 7.4 bpm heart-rate rise at 0.5 mg. Long elimination means effects can linger after a skipped dose; a good watch score does not establish safety.
Drug combinations	Extra stimulants, serotonergic medicines and MAOIs are flagged in the saved cautions. Beta-blockers or supplement sleep stacks do not establish a safe combination.
Trial qualification	The frequently quoted 2008 weight-loss trial has a linked 2013 expression of concern; its headline results need that qualification.

Notes

The frequently quoted 2008 trial has an expression of concern. It studied 0.25, 0.5 and 1 mg daily for 24 weeks with an energy-restricted diet. PubMed links a 2013 expression of concern. Its headline weight-loss figures and comparisons with older drugs should therefore carry that qualification; it was not a comparison with modern GLP-1 treatments. Astrup et al. 2008 obesity trial — PubMed abstract and linked expression of concern (Official context · Accessed 2026-09-30)

Full notes

What Tesofensine does

It changes brain signaling involved in appetite. Also called NS2330, it slows the reuptake of serotonin, norepinephrine and dopamine. That means those signals remain available longer. Its mechanism differs from GLP-1 drugs, even when communities compare their weight-loss effects. Official context Community
Most accounts concern swallowed capsules or tablets. Liquids, powders and occasional sublingual reports also appear; the latter means held under the tongue. Those forms do not establish equivalent absorption. Placement on a peptide seller's shelf does not turn it into an injectable peptide. Community Anabolic Steroid Forums

Benefits people seek

Less snacking and less attention on food. One two-week account described smaller lunches and reduced sugar and alcohol cravings. Another described satisfying small meals rather than complete appetite loss. These are individual experiences, not evidence that it treats alcohol dependence. Reddit · r/Peptides Reddit · r/Tesofensine_
Energy or focus can improve without appetite improving. Users sometimes like the motivation or clearer thinking while still feeling hungry. Others become tired or emotionally flat. A noticeable mental effect is not proof of weight loss or an established ADHD or depression treatment. Reddit · r/Peptides Reddit · r/NooTopics Reddit · r/Tesofensine_

Doses people discuss

These describe reports and circulated charts, not a regimen. 1 mg equals 1,000 mcg; each daily amount below refers to oral use unless specified.

250–500 mcg (0.25–0.5 mg) once daily. These recur in reviewed accounts. Existing charts describe holding 250 mcg for 1–4 weeks before 500 mcg; one diary instead changed after two days. Neither establishes a safe titration schedule. Reddit · r/Peptides Reddit · r/Tesofensine_ Community
Skip-day amounts and 1 mg reports are separate patterns. A NooTopics commenter reported 125 mcg every other day; a BodyHackGuide poster reported 500 mcg every other day after an unpleasant increase. That thread also contains a 500 mcg-to-1 mg escalation followed by three difficult days. These are not interchangeable daily totals. Reddit · r/NooTopics Reddit · r/BodyHackGuide

Half-life: why accumulation comes up

Half-life is the time for the measured amount to fall by half. It is not the time until all drug is gone or a feeling stops.

About 8–9 days is repeated in community discussion. This repeats human clinical-program kinetics, not a forum measurement or an animal-to-human conversion. Users invoke it to explain delayed buildup and skip-days. A half-life plotter's estimated milligrams are not measured blood levels or a new dose target. Reddit · r/BodyHackGuide Reddit · r/Peptides
Weeks to build up is a different question from onset. Existing guides circulate 4–6 weeks, sometimes about 8 weeks, for levels to stabilize, with multi-week or 1–2 month clearance estimates. These are informal planning claims, not personal clearance measurements or drug-test windows. Community

Onset: when people notice something

Appetite reports range from 1–2 days to the second week. One 500 mcg account described a day-or-two response. A 250 mcg daily log noticed its biggest changes on days 8–14. Another diary placed appetite changes around day 10, but had also stopped Wellbutrin and started sermorelin. Reddit · r/Peptides Reddit · r/Peptides Reddit · r/Tesofensine_
No appetite change after two weeks or a month also appears. BodyHackGuide includes a two-week nonresponse at 500 mcg. A Peptides author remained hungry after over a month despite mood and sleep changes. Waiting longer does not guarantee a response; early sleep disturbance can arrive before any appetite benefit. Reddit · r/BodyHackGuide Reddit · r/Peptides Reddit · r/NooTopics

Duration: how long the experience lasts

There is no dependable single-dose appetite window. The reports describe repeated use. One commenter said hunger returned two days after stopping a four-month run; another said early appetite quiet faded during continued use. Those experiences do not measure elimination or predict anyone else's rebound. Reddit · r/Peptides Reddit · r/Tesofensine_
Feeling alert can outlast a normal sleep period. One 500 mcg poster reported two stretches of 48 hours awake. A reply described fragmented sleep; another described better sleep timing. Forty-eight hours is that person's adverse experience, not a typical benefit duration or evidence of less need for sleep. Reddit · r/Tesofensine_

Cycles and time off

Existing discussions describe 8–12 or 16–24 week blocks. They also contain multi-month or seasonal reuse and 4–8+ week breaks. Reviewed examples include a four-month run followed by a break and two years of unspecified on/off use. No shared optimal cycle or proven tolerance reset emerges. Community Reddit · r/Peptides Reddit · r/BodyHackGuide
A couple of days off is not a full washout. Posters skip days because of tiredness, appetite preferences or sleep disruption; the existing record notes disagreement about irregular intake. Continuous clinical treatment and these informal patterns answer different questions. The 8-weeks-on/4-off question in BodyHackGuide is a question, not a verified practice. Reddit · r/Tesofensine_ Reddit · r/Tesofensine_ Reddit · r/BodyHackGuide Community

Good to know

Sleep, pulse, mood and digestion can change together. Reports include insomnia, dry mouth, constipation, headache, restlessness, anxiety and flat or depressed mood. One user reported erectile difficulty and sweating; another reported tinnitus persisting after stopping. Those individual accounts cannot establish causation or frequency. Morning use does not guarantee undisturbed sleep. Reddit · r/NooTopics Reddit · r/Peptides Reddit · r/Tesofensine_ Community
A skipped dose does not remove accumulated exposure. Long elimination makes lingering effects a concern. The published trial reported a 7.4 bpm heart-rate increase at 0.5 mg. A reassuring watch score or a good first week cannot establish cardiovascular safety. Official context Official context Reddit · r/Tesofensine_
Extra stimulants and medication changes complicate the picture. Forum users discuss stronger pre-workout effects and trouble sleeping with caffeine or yohimbine. Existing cautions also flag serotonergic drugs and MAOIs. Supplement sleep stacks, beta-blockers or a seller's reassuring copy do not establish a safe combination. AnabolicMinds Community Community

From community discussion

A smaller appetite and a smaller waist are different outcomes. The two-week lifter log also changed calories, alcohol and training after an MK-677 bulk. An ASF poster remained hungry through a 12-week run and could not separate weight change from diet. Metabolism and lean-preservation explanations remain claims, not conclusions from a scale. Reddit · r/Peptides Anabolic Steroid Forums Community
Tracker improvements coexist with flat energy and higher pulse reports. A diary described improved Oura HRV and sleep during medication changes; a commenter reported lower resting pulse but later less energy and appetite benefit. Another described getting tired and flat. Existing reports include resting pulse about 10 bpm higher; none is a controlled comparison. Reddit · r/Tesofensine_ Community
GLP-1 add-ons are discussed for residual hunger or fatigue. Reviewed accounts combine tesofensine with tirzepatide or later retatrutide. Other existing stack talk names semaglutide, Cardarine, 5-Amino-1MQ, AOD-9604 and HGH fragments. Diet and multiple compounds obscure credit; these reports do not establish synergy or combination safety. Reddit · r/Peptides Reddit · r/Tesofensine_ Community
Dry-mouth tricks and self-monitoring are part of the practical talk. Water, sugar-free gum, early-day timing, a home BP cuff and sleep/mood logs recur. Resting-pulse thresholds around 90 bpm or 10–15 above baseline are informal heuristics, not safe limits. These observations also are not a blood test proving benefit. Community Community
Plain Tesofensine, Tesomet and shop blends are different products. The existing record describes Tesomet as tesofensine plus metoprolol, including a studied 0.5 mg/50 mg combination. BioFlow-style seller blends instead add magnesium L-threonate and taurine, with no component amounts recorded here. Their 'sides cover' pitch does not prove protection or equivalence to Tesomet. Community
Units and product identity remain practical uncertainties. Capsule, powder and dropper labels are not verified exposure. The NooTopics thread contains a '500mg' entry and AnabolicMinds contains '25mg'; neither author clarifies the unit. Those entries are excluded from the dose picture rather than silently repaired to micrograms. Reddit · r/NooTopics AnabolicMinds Community

The research behind circulated claims

Human kinetics distinguish parent drug from metabolite. A Saniona protocol summarizes about 220 hours (9 days) for tesofensine and 374 hours (16 days) for NS2360, its metabolite. These are clinical-program measurements, not felt-duration clocks. Food did not materially change relative bioavailability in that summary. Official context
The frequently quoted 2008 trial has an expression of concern. It studied 0.25, 0.5 and 1 mg daily for 24 weeks with an energy-restricted diet. PubMed links a 2013 expression of concern. Its headline weight-loss figures and comparisons with older drugs should therefore carry that qualification; it was not a comparison with modern GLP-1 treatments. Official context