STUDresearch · Non-peptide
C60
Also known as
carbon 60 · fullerene · buckminsterfullerene · buckyballs · C60-OO · C60 olive oil
Community talk. May contain inaccuracies. Not medical advice. Not a protocol. Not for human or animal use.
Non-peptide
Some talk
Systemic
Oral oil
Longevity & cellular energy
Whole-body oral oil in the longevity talk — not a peptide pin.
What people say
C60 is a carbon fullerene commonly sold dissolved in olive oil. A famous 2012 rat lifespan result was not reproduced in a 2021 mouse study, which also identified light-dependent toxicity in exposed preparations.
Doses people talk about
A teaspoon is not a fixed milligram amount, and neither animal mg/kg regimen is a human conversion.
How it may feel
Human anecdotes conflict sharply: no appreciable effect, more stamina, mild immediate energy/calm, and next-day adverse mental and fatigue symptoms all appear. No consistent onset or duration emerges.
Community oil-volume range1 teaspoon to 1 tablespoon
Concentration varies by product, so volume alone does not identify a C60 amount.
Baati animal regimens4 mg/kg single-dose PK; 1.7 mg/kg repeated oral doses
Separate rat experiments; the repeated study used a declining-frequency schedule rather than 4 mg/kg every two weeks.
Half-life & effect duration
- Half-life in the body
- Oral C60 in oilNo settled estimate
- Felt duration people report
- Positive accountsImmediate mild energy or calm; sometimes more stamina
- Other accountsNo appreciable effect over long use, or next-day fatigue and mental symptoms
Cycles people discuss
Community use includes daily oil for months and weekly or every-other-week patterns copied from animal research. Neither is a human-validated cycle.
Timing
Baati reported gastrointestinal absorption and elimination over tens of hours in rats, not a calculated human half-life. Light exposure is a preparation-safety issue, not a dosing-clock substitute.
Around the dose
It’s olive oil calories. Tablespoons add up.
Stacks
Olive oil is the carrier and a biologically relevant control, not evidence that the fullerene caused a reported effect. Other longevity agents create additional attribution noise.
Watch for
Light-dependent toxicity (mice): C60-OO left in ambient light made species that caused serious harm in under two weeks. Store dark.
Tap a line for the full notes and source context.
Timing context & sources
Half-life in the body
The checked Baati report describes absorption and elimination over tens of hours but does not provide a clean human half-life.
The paper used 4 mg/kg for single-dose PK and 1.7 mg/kg per dose in the repeated oral lifespan experiment.
Rat disposition and a particular oil preparation do not establish human kinetics, chronic exposure, subjective duration or a dosing interval.
- The prolongation of the lifespan of rats by repeated oral administration of [60]fullerene (opens in a new tab)PubMed abstract plus full-paper methods/results inspected for the 0.8 mg/ml oil, 4 mg/kg single-dose oral/IP PK and 1.7 mg/kg repeated oral regimen.Rat study with small groups and a specific preparation; not a human PK, safety or efficacy study, and the abstract does not report a numeric half-life.
Felt duration people report
The inspected accounts do not establish a repeatable felt-effect window.
Reports range from no appreciable effects over long use to immediate mild energy/calm, next-day adverse mental/fatigue symptoms, or more stamina without less baseline fatigue.
Unverified preparation chemistry, self-selection, baseline illness, varying exposure, no blinding and no objective link between sensations and C60 disposition.
- C60 in olive oil (opens in a new tab)Visible comments: Beef_Newton reports no appreciable effects across vendors/long use; NukeZA reports cardio, alcohol-tolerance and mosquito-bite changes but no cure-all.Different anonymous users and unverified products; no controlled exposure, concentration verification or objective causal attribution.
- What's the general consensus on the effectiveness of C60 nowadays? (opens in a new tab)NukeZA same-author long-term account: use since 2015, approximately 5 mg/week most of the time, claimed cardio/alcohol-tolerance effects and no observed side effects.Single retrospective self-report with self-prepared product, no blinding, no assay and no evidence that normal bloodwork establishes safety.
- C60 in olive oil — a recommendation (opens in a new tab)stevesayshi posts 1, 4, 7 and 9: 3 mg five days/week, early stamina claim, then repeated distinction between greater stamina and unchanged exhaustion.Single person with ME/CFS, unverified preparation and no control; same-author follow-ups narrow rather than confirm the headline claim.
- ME/CFS patient makes major improvement and goes back to work from C60 supplement (opens in a new tab)Hip post 1: one 1 ml dose, immediate mild awareness/energy/calm, followed by next-day depression, fatigue, mild psychosis-like symptoms and about two days of PEM; no redose.Single dose in a baseline-prone individual, unverified product and subjective outcomes; title refers to another story, not this poster's controlled result.
Other context in this card
- C60 in olive oil causes light-dependent toxicity and does not extend lifespan in mice (opens in a new tab)Abstract, methods and results: vendor/preparation comparison, ambient-light toxic-species experiment and oral/IP mouse lifespan and healthspan tests.Mouse experiments and preparation-specific chemistry; they do not establish human benefit or the safety of every fullerene formulation.
What people say
- Energy anecdotes: r/Nootropics-era gym and “clean energy” posts. Confounded by oil calories, training, and expectation. anecdote
- Community interpretation is split: Long-running users report anything from no appreciable effect to cardio or alcohol-tolerance changes, while later discussions foreground the failed lifespan replication and light-dependent toxicity finding. These are not human efficacy data. forum
- The 2012 rat paper: Oral C60 in olive oil, repeated doses, near-doubled lifespan in that study — antioxidant / oxidative-stress story. Famous, not human. animal
- Failed mouse lifespan: Adult or old C57BL/6J mice, C60-EVOO vs EVOO vs nothing — no significant lifespan or healthspan win. animal
- Antioxidant / skin cosmetics: Separate topical fullerene lane (gels twice daily in some product trials). Not the longevity dropper. trial
Doses people talk about
- Oil spoon talk: 1 teaspoon to 1 tablespoon of C60 olive oil is the home-biohack range. Concentration varies by brand, so a teaspoon is not a milligram. forum
- Vendor “saturation then maintenance” calculators exist. They are marketing arithmetic. forum
- Daily vs few×/week: Both show up. Nobody has a half-life that settles it. forum
- Example label math: ~25.6 mg C60 per ounce ≈ a few milligrams per teaspoon if that label is honest. forum
- Framing: Vendor droppers and oil teaspoons — not a human PK label. forum
- Baati rat regimens: The single-dose pharmacokinetic experiment used 4 mg/kg orally or intraperitoneally. The repeated oral lifespan regimen used 1.7 mg/kg per dose at the paper’s declining-frequency schedule. Neither is a human dose chart. animal
How it may feel
- Days 1–7 reports conflict: One forum user described mild immediate energy/calm after 1 ml, then next-day depression, fatigue and mild psychosis-like symptoms; other long-term users report no appreciable acute effect. Product identity and baseline illness limit attribution. forumanecdote
- Weeks 2–8: Early nootropic logs lived here. anecdote
- Months: Longevity people who stayed on it rarely have a biomarker story beyond “I still take it.” forum
- After Grohn: A chunk of r/longevity quietly stopped or moved the bottle to a cupboard. forum
- If you feel worse after a sun-hit bottle: That’s the light-toxicity thread, not a detox. animal
Around the dose
- It’s olive oil calories. Tablespoons add up. forum
- Don’t photobleach the bottle then chug it. forum
- Dark glass, no windowsill. The replication paper made that the whole conversation. animal
Cycles people discuss
- Daily oil for months is the classic longevity-bottle habit. forum
- Pulsed (weekly / every other week) copies the rat schedule more than human data. forum
- Not a 10-day Khavinson course. This is a carbon particle in fat. forum
Timing
- With food / as the oil: It’s already in fat. forum
- Not a morning-stim clock. forum
- PK honesty: Human plasma curves for oral C60-OO are not a clean public package. trial
- Light is the timing that matters: Grohn: ambient-light-exposed C60-OO formed toxic species. Dark storage is the actual ritual. animal
More on what it is
- What it is: Soccer-ball carbon cage, 60 carbons. Hydrophobic, so people dissolve it in extra-virgin olive oil (C60-OO). Not a peptide. forum
- Forum split: Early r/Nootropics “ultimate energy / gym PR” logs vs later “it didn’t replicate, keep it in the dark or skip it.” forum
- Product: Dropper bottles of purple-brown oil. Concentration is a vendor claim (one consumer brand advertises ~25.6 mg C60 per ounce). forum
- Not: Not olive oil as the active, not graphene, not a mitochondrial peptide. forum
- Why it exploded: Baati 2012 — rats on C60 olive oil lived a lot longer in that paper. r/todayilearned still recycles it. animal
- Replication punch: Grohn 2021 — C60-OO did not extend lifespan in mice, and light-exposed oil made toxic species that could sicken mice in under two weeks. r/longevity actually read this one. animal
Stacks
- Urolithin A / ALA / polyphenol antioxidant stacks: Same longevity aisle, different molecules. forum
- Not a rapamycin substitute. forum
- EVOO itself: The control arm that already failed to beat untreated mice in Grohn. animal
Storage notes
- No mix instructions here: STUDresearch does not list DIY toluene-extraction recipes. Home chemistry is how people get hurt. forum
- Dark, cool, sealed. Light + oil is the caution the 2021 mouse paper made famous. animal
Watch for
- GI / oil load: Tablespoons of oil. forum
- Solvent leftovers: Shady “C60” that was cooked in toluene is a purity horror story. forum
- Light-dependent toxicity (mice): C60-OO left in ambient light made species that caused serious harm in under two weeks. Store dark. animal
- No lifespan win in the Grohn mouse oral study. animal
- Unknown human chronic toxicity. trial
- Don’t inject random fullerene oil. The IP mouse arm also failed a lifespan claim. animal
- Not a proven human anti-aging drug. trial
- Research-only framing: Discussion of community practice — not a recommendation to use in humans or animals. forum
Evidence mix
Mostly community / anecdote tags
Full: every bullet (trial + community). Use Scan for a faster bro-science read.