Peptide

HMG (Menotropin)

Also known as

Human Menopausal Gonadotropin · Menopur · hMG 75IU

Community talk. May contain inaccuracies. Not medical advice. Not a protocol. Not for human or animal use.

What it is

Compound	Human menopausal gonadotropin, or menotropins, is an injectable fertility medicine with FSH and LH activity.
Units	Menopur supplies 75 IU of each activity per vial. These are activity units, not milligrams or a combined 150-IU dose.
Different uses	Men discuss sperm recovery with HCG; ovarian-stimulation patients discuss Menopur. HMG, HCG and FSH-only products are different medicines.

Notes

HMG, or menotropins, is an injectable fertility medicine. Men discuss sperm recovery with HCG; ovarian-stimulation patients discuss Menopur. Fertility outcomes differ from the soreness or burning people may notice.

HMG combines two reproductive hormone activities. Human menopausal gonadotropin provides follicle-stimulating hormone (FSH) and luteinizing hormone (LH) activity. Menopur comes from postmenopausal donors' urine, with 75 IU of each per vial. IU means activity, not milligrams or a combined 150-IU dose. DailyMed — MENOPUR prescribing information (Official context · Accessed 2026-09-30)

HMG, HCG and FSH-only injections are different. FSH-only injections change the medicine. HCG and testosterone replacement therapy (TRT) often accompany male HMG use, complicating attribution of benefits and side effects. DailyMed — MENOPUR prescribing information (Official context · Accessed 2026-09-30)

Source context — DailyMed — MENOPUR prescribing information: U.S. ovarian-treatment label, revised May 2018. Female FSH measurement; no male or separate LH kinetics established. Label-derived identity, kinetics and cautions remain formal context, distinct from the quick summary's personal accounts.

What people notice

Male fertility outcomes	Accounts include conception and improving semen tests alongside months without pregnancy. Libido, semen volume or testicular size alone do not establish sperm recovery.
Ovarian outcomes	One contributor felt Menopur improved egg maturity, but both described cycles ended in very early pregnancy losses; other medicines were involved.
Local reactions	Burning, soreness, redness, itching, lumps and bruises are reported; these are separate from fertility outcomes.

Notes

Sperm recovery and conception. Male accounts include pregnancies and improving semen tests, alongside prolonged trying without pregnancy. Feeling sexually better, producing more semen or noticing larger testicles does not by itself establish sperm recovery. TRT + HMG + HCG — fertility success stories and reactions (Community discussion · Accessed 2026-09-30) · Humog Menotrophin has anyone used it (Personal report · Accessed 2026-09-30)

Pregnancy and ongoing difficulty appear side by side. SouthernUtahPPG reported conception in month three while continuing TRT. DangerousPut7056 switched after six weeks of painful HMG, interrupted FSH for a month, and still reported no pregnancy around month 3–3.5 despite encouraging numbers. These are two people; the latter's updates are one continuing account. TRT + HMG + HCG — fertility success stories and reactions (Community discussion · Accessed 2026-09-30)

More mature eggs, without a guaranteed pregnancy. A fertility-forum contributor felt Menopur improved egg maturity, yet both described cycles ended in very early pregnancy losses. Egg retrieval, fertilization and an ongoing pregnancy are different outcomes; other medicines were also involved. Your experience with menopur? (Community discussion · Accessed 2026-09-30)

Burning, redness, itching, lumps and bruises deserve attention. Patients describe stinging alongside these other local complaints. An anonymous account cannot determine whether a reaction came from the medicine, an ingredient, injection conditions or an unverified product. Serious allergy symptoms, chest pain or neurological changes need medical care. Your experience with menopur? (Community discussion · Accessed 2026-09-30)

Source context — TRT + HMG + HCG — fertility success stories and reactions: Removed opening post; visible replies only. Anonymous combination accounts, uncertain units and products, incomplete tests; updates from one person are not corroboration. Relative timestamps do not establish exact dates.

Source context — Humog Menotrophin has anyone used it: Commercial source-review environment; HCG co-use, no objective fertility result, injection route absent. Claimed size response cannot validate a sperm endpoint.

Source context — Your experience with menopur?: April 2010 discussion, unverified clinic accounts with co-treatment. The claimed preservative cause of burning is not established; advice about injection technique not adopted.

Doses people talk about

Male per-injection reports	75 IU appears with twice-weekly, every-other-day, or Monday/Wednesday/Friday schedules, often with HCG. These are separate reports; route is not consistently stated.
Unresolved unit	One pregnancy account writes 75 mg HMG three times weekly with 666 IU HCG per injection. The HMG unit is unresolved and cannot be silently converted to IU.
Ovarian-stimulation reports	Separate IVF accounts describe 75 IU Menopur daily or 300 IU nightly beneath the skin. These cannot be pooled into a male range.

Notes

Male reports: 75 IU per injection, with different frequencies. Opened accounts describe twice weekly, every other day, or Monday, Wednesday and Friday. These are separate schedules, often involving HCG; they are not a daily amount or one agreed regimen. The male posts do not consistently identify injection route or verify the product. So who has used HMG for PCT (Community discussion · Accessed 2026-09-30) · Humog Menotrophin has anyone used it (Personal report · Accessed 2026-09-30) · Fertility Journey (Hope for anyone thinking of trying) (Personal report · Accessed 2026-09-30)

One pregnancy account wrote 75 mg, not IU. SouthernUtahPPG reported HMG three times weekly with 666 IU HCG per injection. The mg unit remains unresolved. Another user's later 75-IU figure was FSH after switching, not their HMG amount. TRT + HMG + HCG — fertility success stories and reactions (Community discussion · Accessed 2026-09-30)

Ovarian-stimulation reports are a separate dose picture. In an IVF thread, one patient described 75 IU Menopur daily, another 300 IU nightly under the skin. Monitoring could change the dose; other stimulation drugs and ovarian response differed. These accounts cannot be pooled into a male HMG range. What cycle day do you take your Menopur? What dose? (Community discussion · Accessed 2026-09-30)

Source context — So who has used HMG for PCT: Promotional claims mixed with anonymous experience. Natural-LH and HCG comparisons are not HMG measurements. Proposed seven-day use has no outcome; swole's signature explicitly disclaims reliability.

Source context — Fertility Journey (Hope for anyone thinking of trying): Commercial bodybuilding forum; product-testing accusation unverified, treatment and supplements changed together. Log dates refer to 2024; thread displayed January 2025 dates. No HMG-only outcome established.

Source context — What cycle day do you take your Menopur? What dose?: Anonymous ovarian-treatment accounts with different responses and other drugs. SC route stated by KlimRous only. Exact post date unavailable in opened relative timestamps.

Half-life, onset & duration

Felt onset	One person reported early testicular-size recovery while also using HCG. There was no accompanying semen result or reliable same-day libido onset.
Felt duration	No repeatable beneficial feeling window or post-stop fertility duration is established. One local reaction began around 12 hours and hurt for days.
Half-life	About 11–13 hours for measured FSH after under-skin or intramuscular Menopur in 33 pituitary-suppressed premenopausal women; this is not male or separate LH-activity kinetics.

Notes

One early size report is not fertility onset. An Eroids commenter noticed testicular size recovery after the first HMG injection while also using HCG. No semen result accompanies that claim, so it cannot establish when HMG alone starts improving sperm production. A reliable same-day libido onset remains unknown. Humog Menotrophin has anyone used it (Personal report · Accessed 2026-09-30)

No reliable beneficial feeling window. Fertility accounts do not give a repeatable number of hours of benefit after an injection, or establish how long improved fertility persists after stopping HMG.

One adverse reaction began around 12 hours and hurt for days. DangerousPut7056 described delayed redness, pain and bruising. That is a local reaction timeline, not HMG's half-life or therapeutic duration. TRT + HMG + HCG — fertility success stories and reactions (Community discussion · Accessed 2026-09-30)

The measured FSH half-life is about 11–13 hours. This came from 33 premenopausal women with pituitary suppression, after under-skin or intramuscular Menopur. It measures FSH in blood, not separate LH activity, male kinetics or time to pregnancy. DailyMed — MENOPUR prescribing information (Official context · Accessed 2026-09-30)

No community-measured male HMG half-life. Older bodybuilding threads ask this question or reason from natural LH and HCG. Those comparisons do not measure HMG. Injection frequency is not proof of how quickly either component leaves the body; the specific female Menopur measurement appears separately below. Couple HMG questions (Community discussion · Accessed 2026-09-30) · So who has used HMG for PCT (Community discussion · Accessed 2026-09-30)

Source context — Couple HMG questions: Unsourced advice, no measured half-life or verified stability data; storage recommendation not adopted. Commercial forum context.

Cycles people discuss

Male fertility logs	Reports span months. One combined-drug log added HMG in February and stopped in June; it does not establish a universal course.
Ovarian stimulation	Separate IVF accounts describe ten or eleven monitored stimulation days with other medicines, rather than a male on/off cycle.

Notes

Male fertility logs span months. One bodybuilding log added HMG in February and stopped the combination in June. Short post-cycle-therapy suggestions describe attempts to recover hormone function after steroid use; they do not establish a successful fertility course or universal on/off calendar. Fertility Journey (Hope for anyone thinking of trying) (Personal report · Accessed 2026-09-30) · So who has used HMG for PCT (Community discussion · Accessed 2026-09-30)

Ovarian stimulation is counted in monitored days. One IVF contributor described ten stimulation days before a trigger injection, another eleven days with other medicines. This differs from the multi-month male accounts and does not establish a repeat-cycle schedule. What cycle day do you take your Menopur? What dose? (Community discussion · Accessed 2026-09-30)

Stacks

HCG and TRT	Male reports combine HMG with HCG while reducing or continuing testosterone replacement; some later switch to FSH-only treatment.
Other fertility medicines	Ovarian accounts involve other stimulation drugs. Egg and pregnancy outcomes cannot be assigned to HMG alone.

Notes

Off-label male reports: Multi-month HMG/HCG use appears in fertility discussions, sometimes alongside reduced or continued TRT and later FSH substitution; no universal on/off schedule follows from these accounts. [community]

Watch for

Injection reactions and contents	Painful redness, itching, lumps or bruising may involve the medicine, ingredients, injection conditions or an unverified product; the reports do not establish the cause.
Ovarian overstimulation	Menopur labeling warns of serious complications. Severe pelvic pain, rapid weight gain, vomiting or breathlessness need urgent assessment, including after treatment ends.
Hormone changes	Libido changes, flushing, nausea and hormone swings appear in combination discussions; HCG-only experiences are not HMG outcomes.
Pregnancy and interactions	Menopur is contraindicated during pregnancy; human drug-interaction studies are absent.

Notes

A successful story does not verify a vial. The bodybuilding log alleges falsified product testing, leaving its HMG identity uncertain. Gray-market preparations also bring uncertainty about impurities and long-term safety. Fertility Journey (Hope for anyone thinking of trying) (Personal report · Accessed 2026-09-30)

Ovarian overstimulation can become serious. Menopur labeling warns of fluid accumulation, clots and kidney or lung complications. Severe pelvic pain, rapid weight gain, vomiting or breathlessness require urgent assessment, even after treatment ends. It is contraindicated during pregnancy; human drug-interaction studies are absent. DailyMed — MENOPUR prescribing information (Official context · Accessed 2026-09-30)

Hormone combinations complicate both benefits and side effects. Community discussion includes libido changes, flushing, nausea and hormone swings, without evidence these routinely precede benefit. Other hormones and estrogen-lowering medicines change the picture; a report about HCG alone is not an HMG experience. Has anyone used HMG? What was your experience like? (Community discussion · Accessed 2026-09-30)

Source context — Has anyone used HMG? What was your experience like?: Reply explicitly says HMG was never used; no-side-effects account concerns HCG plus anastrozole. Not counted as HMG tolerance or effectiveness evidence.

Full notes

What HMG is and why the names matter

HMG combines two reproductive hormone activities. Human menopausal gonadotropin provides follicle-stimulating hormone (FSH) and luteinizing hormone (LH) activity. Menopur comes from postmenopausal donors' urine, with 75 IU of each per vial. IU means activity, not milligrams or a combined 150-IU dose. Official context
HMG, HCG and FSH-only injections are different. FSH-only injections change the medicine. HCG and testosterone replacement therapy (TRT) often accompany male HMG use, complicating attribution of benefits and side effects. Official context Community

Benefits people seek and report

Sperm recovery and conception. Male accounts include pregnancies and improving semen tests, alongside prolonged trying without pregnancy. Feeling sexually better, producing more semen or noticing larger testicles does not by itself establish sperm recovery. Reddit r/Testosterone Personal report
More mature eggs, without a guaranteed pregnancy. A fertility-forum contributor felt Menopur improved egg maturity, yet both described cycles ended in very early pregnancy losses. Egg retrieval, fertilization and an ongoing pregnancy are different outcomes; other medicines were also involved. The Bump

Doses people discuss

Male reports: 75 IU per injection, with different frequencies. Opened accounts describe twice weekly, every other day, or Monday, Wednesday and Friday. These are separate schedules, often involving HCG; they are not a daily amount or one agreed regimen. The male posts do not consistently identify injection route or verify the product. EliteFitness Personal report Personal report
One pregnancy account wrote 75 mg, not IU. SouthernUtahPPG reported HMG three times weekly with 666 IU HCG per injection. The mg unit remains unresolved. Another user's later 75-IU figure was FSH after switching, not their HMG amount. Reddit r/Testosterone
Ovarian-stimulation reports are a separate dose picture. In an IVF thread, one patient described 75 IU Menopur daily, another 300 IU nightly under the skin. Monitoring could change the dose; other stimulation drugs and ovarian response differed. These accounts cannot be pooled into a male HMG range. Reddit r/IVF

Half-life in community discussion

No community-measured male HMG half-life. Older bodybuilding threads ask this question or reason from natural LH and HCG. Those comparisons do not measure HMG. Injection frequency is not proof of how quickly either component leaves the body; the specific female Menopur measurement appears separately below. EliteFitness EliteFitness

When people notice a change

One early size report is not fertility onset. An Eroids commenter noticed testicular size recovery after the first HMG injection while also using HCG. No semen result accompanies that claim, so it cannot establish when HMG alone starts improving sperm production. A reliable same-day libido onset remains unknown. Personal report Community

How long noticeable effects last

No reliable beneficial feeling window. Fertility accounts do not give a repeatable number of hours of benefit after an injection, or establish how long improved fertility persists after stopping HMG. Community
One adverse reaction began around 12 hours and hurt for days. DangerousPut7056 described delayed redness, pain and bruising. That is a local reaction timeline, not HMG's half-life or therapeutic duration. Reddit r/Testosterone

Courses and interruptions people describe

Male fertility logs span months. One bodybuilding log added HMG in February and stopped the combination in June. Short post-cycle-therapy suggestions describe attempts to recover hormone function after steroid use; they do not establish a successful fertility course or universal on/off calendar. Personal report EliteFitness
Ovarian stimulation is counted in monitored days. One IVF contributor described ten stimulation days before a trigger injection, another eleven days with other medicines. This differs from the multi-month male accounts and does not establish a repeat-cycle schedule. Reddit r/IVF

Cautions that matter

Burning, redness, itching, lumps and bruises deserve attention. Patients describe stinging alongside these other local complaints. An anonymous account cannot determine whether a reaction came from the medicine, an ingredient, injection conditions or an unverified product. Serious allergy symptoms, chest pain or neurological changes need medical care. The Bump Community
A successful story does not verify a vial. The bodybuilding log alleges falsified product testing, leaving its HMG identity uncertain. Gray-market preparations also bring uncertainty about impurities and long-term safety. Personal report Community
Hormone combinations complicate both benefits and side effects. Community discussion includes libido changes, flushing, nausea and hormone swings, without evidence these routinely precede benefit. Other hormones and estrogen-lowering medicines change the picture; a report about HCG alone is not an HMG experience. Community AnabolicMinds
Ovarian overstimulation can become serious. Menopur labeling warns of fluid accumulation, clots and kidney or lung complications. Severe pelvic pain, rapid weight gain, vomiting or breathlessness require urgent assessment, even after treatment ends. It is contraindicated during pregnancy; human drug-interaction studies are absent. Official context

Separate Menopur label context

The measured FSH half-life is about 11–13 hours. This came from 33 premenopausal women with pituitary suppression, after under-skin or intramuscular Menopur. It measures FSH in blood, not separate LH activity, male kinetics or time to pregnancy. Official context
The U.S. labeled course concerns ovarian stimulation. After pituitary suppression, its under-skin start is 225 IU daily. Response is assessed after five days; adjustments are capped at 150 IU, with limits of 450 IU/day and 20 days. Ultrasound and estrogen monitoring guide care. These values concern women. Official context

What the community accounts show

Pregnancy and ongoing difficulty appear side by side. SouthernUtahPPG reported conception in month three while continuing TRT. DangerousPut7056 switched after six weeks of painful HMG, interrupted FSH for a month, and still reported no pregnancy around month 3–3.5 despite encouraging numbers. These are two people; the latter's updates are one continuing account. Reddit r/Testosterone
Poor results can carry emotional and financial costs. Adoniss87's log described sperm concentration falling during combined HMG/HCG use while on testosterone, then rising after stopping all three and adding supplements. Multiple changes and disputed product authenticity prevent attributing either phase to HMG alone. Personal report
A hormonal feeling is a different claim from restored fertility. An older EliteFitness user described a perceived testosterone boost on 75 IU twice weekly, with fewer estrogen-type complaints than HCG. No supporting hormone or semen tests were supplied; the poster's signature also explicitly disclaims factual reliability. EliteFitness
Storage advice is product-specific, too. An older forum reply treats mixed HMG like HCG and proposes a month in the refrigerator. That unsourced generalization cannot establish stability for every menotropin preparation; handling requirements must come from the actual product information. EliteFitness