Non-peptide

Luteolin

Also known as

Luteolin flavonoid · 3',4',5,7-tetrahydroxyflavone · lutolin · CD38 luteolin · peanut-hull luteolin (discussed)

Community talk. May contain inaccuracies. Not medical advice. Not a protocol. Not for human or animal use.

What it is

Identity	A plant flavonoid sold as an oral supplement, discussed for allergy-like symptoms, mast-cell problems, associated brain fog and experimental longevity stacks. It is distinct from lutein.
Formulation matters	Plain, liposomal, phytosome and oil-based products are not automatically equivalent per milligram. Blends may add rutin, quercetin or PEA.

Notes

Luteolin is a plant flavonoid sold as an oral supplement. People discuss it for allergy-like symptoms, mast-cell problems and the brain fog that can accompany them, or add it to experimental longevity stacks. Reports include relief, no change and unwanted effects; the formulation matters.

A plant compound, distinct from lutein. Luteolin is a flavonoid found in plants such as celery and herbs. Lutein, apigenin and quercetin are different compounds; their reports are not interchangeable. This card concerns oral supplements, not injections. Luteolin reduces IL-6 production in microglia (Animal context · Accessed 2026-09-30)

Plain powder, carrier formulations and blends are different products. Liposomal, phytosome and oil-based products are marketed around absorption; some phytosome products claim better uptake at lower milligrams. Equal labeled amounts do not establish equal exposure. Blends may add rutin, quercetin or PEA, short for palmitoylethanolamide. Component amounts and other ingredients matter when interpreting responses.

Source context — Luteolin reduces IL-6 production in microglia: Mouse cells and mice, not human users taking 300 mg. The 90% figure is a cell-culture outcome at 25 micromolar. Used to reject a forum's human-dose extrapolation and support basic identity, never to supply practical human dose/timing.

What people notice

Allergy symptoms and clarity	One poster reported easier nasal breathing while taking Claritin. A liposomal diary initially described clearer thinking, motivation and less allergic reactivity.
Sleep versus daytime benefit	A 100 mg daily user felt tired with morning use and slept better at night, but noticed no other fatigue or brain-fog improvement.
Mixed PEA-LUT experience	One account's early energy and focus improvement was followed by another relapse and later little change. This was one changing combination account.

Notes

Less nasal irritation, itching or fog. An allergy poster describes easier nasal breathing while also taking Claritin. A separate liposomal diary reports initial clearer thinking, motivation and less allergic reactivity. Neither establishes a diagnosis or treatment replacement. Luteolin — solved my allergies pretty well (Community discussion · Accessed 2026-09-30) · Need help understanding reaction to luteolin (Community discussion · Accessed 2026-09-30)

Better sleep and clearer daytime thinking are separate outcomes. The 100 mg MCAS commenter felt tired with morning use and slept better after moving it to night, yet reported no other improvement in their fatigue or brain fog. The blend user reported less edema, fog, appetite noise, cravings, gut swelling and allergies; later benefit and weight changes were confounded by added Zepbound. Anyone who takes/taken luteolin: what's your experience? (Community discussion · Accessed 2026-09-30)

Two days in one diary; about a week for nasal relief. The 10 mg liposomal diary describes clarity during days 1–2; the allergy poster noticed improvement after about a week. A Biohackers commenter found no benefit after 1.5 months. These are different outcomes. Need help understanding reaction to luteolin (Community discussion · Accessed 2026-09-30) · Luteolin — solved my allergies pretty well (Community discussion · Accessed 2026-09-30) · What benefit did you get from luteolin? (Community discussion · Accessed 2026-09-30)

Early PEA-LUT improvement did not become lasting recovery. Butterfly-331 reported more energy, focus and strength after three days and quicker recovery from a relapse. Another intense relapse followed within a week, with dizziness, headache and vision symptoms; some aches improved but other symptoms persisted. The later same-author reply says PEA-LUT did not change much. The initial excitement and later disappointment belong to one account. Neuro Inflammation/MCAS — New studies on PEA-LUT combination (Community discussion · Accessed 2026-09-30)

Source context — Luteolin — solved my allergies pretty well: Self-reported label, unverified liposomal formulation, frequency unspecified; antihistamine co-use prevents isolated attribution. Weight-based and 500 mg recommended-dose reasoning is the poster's claim and is not endorsed. Reply about Nasalcrom timing is a different product and is not luteolin onset evidence.

Source context — Need help understanding reaction to luteolin: Uncontrolled liposomal self-report without verified product or exposure. MAOI, COMT, SIFO and die-off explanations are hypotheses in replies, not diagnoses. The similar r/MCAS post 1p55400 is the same story, not independent corroboration. Intermittent-use suggestion has no reported luteolin result.

Source context — Anyone who takes/taken luteolin: what's your experience?: Different products and baseline complaints. No softgel count per dose in the blend account, so no daily blend component dose reconstructed. Same-author updates remain one account. Claims that supplements cancel prescription effects are not validated interactions; promoter/product-title statements are not label verification. Relative dates not converted to calendar dates.

Source context — What benefit did you get from luteolin?: Single visible nonresponse with no dose, formulation or target outcome. Deleted/removed replies cannot be reconstructed. The OP's impression of promotion does not establish that all positive reports are commercial.

Source context — Neuro Inflammation/MCAS — New studies on PEA-LUT combination: Eight-week amounts originate in a medical trial/registry, not a community-derived dose or cycle. Early improvement, another intense relapse, persistent symptoms and eventual little-change statement are one uncontrolled timeline. Gut/bacterial-toxicity explanation is the author's belief and not established. No purchasing details retained; no completed eight-week outcome invented from the two-week update.

Doses people talk about

Low liposomal diary	One sensitive user reported 10 mg/day for two days, then 20 mg/day. Early benefit was followed by disturbed sleep and cold-like symptoms.
Separate oral amounts	Accounts include 100 mg once daily and a claimed liposomal 250 mg twice daily, 500 mg/day, with other supplements. One different user noticed no effect at 500 mg twice daily.
Blend component amounts	One product title lists 150 mg luteolin, 75 mg rutin and 75 mg PEA. Its 300 mg total is not all luteolin; softgels per reported dose were unstated, so daily component totals are unknown.
Older stack amounts	Notes retain 100–200 mg/day capsules and separate 300 mg or 300 mg/day charts, sometimes with about 50 mg apigenin. Formulations and frequency cannot be assumed equivalent.
Sublingual PEA-LUT combination	A trial-derived schedule repeated by a user contains 700 mg PEA plus 70 mg luteolin per administration, twice daily: 1,400 mg PEA and 140 mg luteolin/day.

Notes

Liposomal diary: 10 mg/day, then 20 mg/day. One sensitive user reports two days at 10 mg before increasing to 20 mg. Early benefit was followed by sleep disturbance and cold-like symptoms. The product's claimed liposomal form and actual exposure were not verified. Need help understanding reaction to luteolin (Community discussion · Accessed 2026-09-30)

Separate oral accounts: 100 mg daily and 250 mg twice daily. One MCAS commenter reports 100 mg once daily; the thread's author reports a product described as liposomal at 250 mg per use, 500 mg/day, alongside two other supplements. Neither amount defines a threshold for benefit. Anyone who takes/taken luteolin: what's your experience? (Community discussion · Accessed 2026-09-30)

Forum amounts also differ. Phoenix Rising's Hip reports about 80 mg daily and experiments up to 300 mg. Longecity's tintinet noticed no effect at 500 mg twice daily, 1,000 mg/day. Formulations were unstated. Luteolin (Community discussion · Accessed 2026-09-30) · Anyone Taking Luteolin? (Community discussion · Accessed 2026-09-30)

A blend lists 150 mg luteolin, 75 mg rutin and 75 mg PEA. Its user reports once-daily, briefly twice-daily use. The 300 mg product title totals three ingredients; it is not 300 mg luteolin. Softgels per reported dose were unstated, so the daily component amounts remain unknown. Anyone who takes/taken luteolin: what's your experience? (Community discussion · Accessed 2026-09-30)

100–200 mg/day and about 300 mg remain in stack discussion. Existing notes give 100–200 mg/day capsule use. A NAD-stack note says 300 mg without frequency; a separate chart says 300 mg/day. Pairing with roughly 50 mg apigenin also appears. These do not establish consensus or a safe upper amount.

PEA-LUT's eight-week course comes from a trial. A Long COVID poster followed circulated sublingual granules containing 700 mg PEA plus 70 mg luteolin per administration, twice daily: 1,400 mg PEA and 140 mg luteolin/day. This is a specific studied combination repeated by a user, not a luteolin-alone cycling rule. Neuro Inflammation/MCAS — New studies on PEA-LUT combination (Community discussion · Accessed 2026-09-30)

Source context — Luteolin: Historical n=1s without verified products. The 300 mg/90% IL-6 human-sounding claim is not supported by its linked mouse/microglial study and is rejected. Statements about other mothers' children are secondhand and omitted; the user's own stimulation report is retained. Web body accessible; a later direct HTTP attempt returned 403.

Source context — Anyone Taking Luteolin?: Historical uncontrolled accounts, unverified formulation and major resveratrol confounding. In-vitro SIRT1, kinase and enzyme hypotheses do not demonstrate human mechanism. No purchasing directions retained. Same maxwatt story quoted by others is counted once.

Half-life, onset & duration

Felt onset	One diary describes clarity during days 1–2; another poster noticed nasal relief after about a week.
Felt duration	Single-dose symptom coverage is unknown. One diarist's unwanted symptoms faded within two days of stopping while baseline MCAS symptoms returned; that is not a clearance measurement.
Half-life	The retained 2–3-hour elimination figure concerns total conjugated luteolin after artichoke extract in 14 people, not free luteolin or plain/liposomal capsule effects.
Blood peak	About 0.5 hours in that artichoke-extract study. This does not time supplement symptom relief.

Notes

Single-dose symptom coverage is unknown. The diarist describes restless sleep around day five and cold-like symptoms during days 5–12. Those symptoms faded the day after stopping and were gone within two days, while baseline MCAS symptoms returned. Recovery timing does not measure drug duration. Need help understanding reaction to luteolin (Community discussion · Accessed 2026-09-30)

The 2–3-hour elimination figure belongs to artichoke-extract research. The 14-person human study used extracts supplying 14.4 or 35.2 mg luteolin equivalents. Blood peaks appeared near 0.5 hours; recovered compounds were sulfate or glucuronide forms, not free luteolin. This extract-specific timing does not establish capsule effects or symptom duration. Wittemer et al. — Human artichoke-extract flavonoid kinetics (Official context · Accessed 2026-09-30)

No community-measured human supplement half-life. Daily use, a return of symptoms after stopping and a change in sleep do not measure how quickly luteolin leaves blood. These accounts provide no dependable clearance number for plain, liposomal or phytosome products; extract-study timing is separate context below.

Source context — Wittemer et al. — Human artichoke-extract flavonoid kinetics: Fresh abstract access only; publisher full text was blocked. Exact 2–3-hour value retained as prior reviewed formal context rather than represented as newly reverified or a community measurement. Extract glycosides and total conjugated forms do not establish supplement-specific free-luteolin timing. Publication metadata supplied a normalized January 1 date; only actual January 2005 issue is claimed.

Cycles people discuss

Ongoing oral use	Daily use appears without a shared on/off calendar. A blend user changed frequency after six weeks and later reported benefit with nightly use by month three.
PEA-LUT course	Eight weeks belongs to a specific PEA/luteolin trial-derived combination schedule, not a luteolin-alone cycling rule or a completed eight-week community outcome.

Notes

Continuous use appears; no shared on/off calendar is established. After six weeks once daily, the blend user briefly doubled frequency after no longer noticing effects. By month three they reported benefit with once-nightly use because of daytime sleepiness. This does not establish a cycle. Anyone who takes/taken luteolin: what's your experience? (Community discussion · Accessed 2026-09-30)

Butterfly-331 OP, circulated 700 mg PEA/70 mg luteolin sublingual granules twice daily for eight weeks, two-week update and later same-author reply. Web text lines 16–43, 66–98 and 117–130. Neuro Inflammation/MCAS — New studies on PEA-LUT combination (Community discussion · Accessed 2026-09-30)

Stacks

Allergy-oriented pairings	Quercetin and vitamin C appear in mast-cell stacks. PEA and rutin occur in blends; Claritin was co-used in the nasal-relief report.
Longevity-oriented pairings	Apigenin, NMN, NR, NAD+, fisetin and 5-Amino-1MQ recur in experimental stacks. The CD38/NAD story does not establish human longevity benefit.
Timing habits	Sedating apigenin combinations are discussed in the evening and NAD stacks in the morning, sometimes with fat-containing food. No superior timing or absorption is established.

Notes

Quercetin and vitamin C: Appear in mast-cell discussions. Concurrent ingredients obscure benefit and reaction attribution. [community]

Experimental NAD support is a different goal. Longevity discussions pair luteolin with apigenin, NMN, NR, NAD+, fisetin or 5-Amino-1MQ. The CD38 story is a hope of slowing an enzyme involved in NAD use, based on laboratory and animal ideas. It is not a demonstrated human longevity benefit or a dependable rapid focus effect.

Timing and storage habits are practical conventions. Community notes place sedating apigenin combinations in the evening and NAD-oriented stacks in the morning, sometimes with a fat-containing meal. None establishes a superior clock or guaranteed absorption. Capsule notes describe dry, dark storage; injectable mixing instructions do not belong to these oral products.

Watch for

Reactions	Reports include stomach upset, sedation, stimulation, disturbed sleep and headache. One first-100-mg account described worsening neuropathic pain despite tolerating quercetin.
Ingredients and source	Extract source and all blend ingredients matter. Peanut-shell-derived extract concerns do not establish actual allergen content; Sophora-derived labeling also does not guarantee tolerability.
Claims and uncertainty	Human longevity benefit, dependable interactions and long-term supplement safety are not established in these accounts. PEA-LUT trial findings do not isolate luteolin or prove brain-fog recovery.

Notes

Natural does not mean free of reactions. One MCAS poster reports strong headache and worsening pain in neuropathy-affected areas after a first 100 mg dose despite generally tolerating quercetin. Existing notes also flag stomach upset and sedation. Product ingredients, underlying illness and co-use complicate attribution; initial improvement does not settle later tolerability. Bad reaction to luteolin, does it get better? (Personal report · Accessed 2026-09-30)

Some forum users describe stimulation or returning pain. Phoenix Rising's invisiblejungle found a blend stimulating. Longecity's maxwatt reported hand and foot pain returning after initial relief during two weeks with resveratrol, then improvement within three days but residual knuckle stiffness. Luteolin (Community discussion · Accessed 2026-09-30) · Anyone Taking Luteolin? (Community discussion · Accessed 2026-09-30)

Allergen source and the full ingredient list matter. Community cautions include peanut-shell-derived extracts, while the headache account used a product described as Sophora-derived. An extraction-source claim alone cannot establish allergen content or safety. Quercetin, vitamin C and other additions can further complicate reactions. Medication interactions and long-term supplement safety remain unresolved by these accounts. Bad reaction to luteolin, does it get better? (Personal report · Accessed 2026-09-30)

A PEA-LUT study does not isolate luteolin's benefit. The eight-week trial used the 700 mg PEA and 70 mg luteolin combination twice daily. Certain brain-stimulation measurements improved, but the cognitive screening tests did not show a significant treatment-by-time difference. That distinction limits claims of proven brain-fog recovery. Co-ultramicronized PEA/luteolin and cortical activity in Long COVID (Official context · Accessed 2026-09-30)

Source context — Bad reaction to luteolin, does it get better?: Self-reported underlying illness, unverified ingredient source and product; causality not established. No recovery, later tolerance or long-term outcome is claimed from the inspected opening.

Source context — Co-ultramicronized PEA/luteolin and cortical activity in Long COVID: Small combination trial, not luteolin alone. Neurophysiology findings do not demonstrate cognitive recovery, predictable symptom onset or long-term safety. Abstract describes 39 participants; section 2.2 describes 17 per group, so no denominator generalized in the public article. Community repetitions and registry/manufacturer reprints share this research origin.

Full notes

What luteolin is, and why the form matters

A plant compound, distinct from lutein. Luteolin is a flavonoid found in plants such as celery and herbs. Lutein, apigenin and quercetin are different compounds; their reports are not interchangeable. This card concerns oral supplements, not injections. Community Animal context
Plain powder, carrier formulations and blends are different products. Liposomal, phytosome and oil-based products are marketed around absorption; some phytosome products claim better uptake at lower milligrams. Equal labeled amounts do not establish equal exposure. Blends may add rutin, quercetin or PEA, short for palmitoylethanolamide. Component amounts and other ingredients matter when interpreting responses. Community

What people hope to gain

Less nasal irritation, itching or fog. An allergy poster describes easier nasal breathing while also taking Claritin. A separate liposomal diary reports initial clearer thinking, motivation and less allergic reactivity. Neither establishes a diagnosis or treatment replacement. Reddit r/Supplements Reddit r/HistamineIntolerance
Experimental NAD support is a different goal. Longevity discussions pair luteolin with apigenin, NMN, NR, NAD+, fisetin or 5-Amino-1MQ. The CD38 story is a hope of slowing an enzyme involved in NAD use, based on laboratory and animal ideas. It is not a demonstrated human longevity benefit or a dependable rapid focus effect. Community

Doses people discuss

Reported amounts describe different products and individual experiments, not a recommended range.

Liposomal diary: 10 mg/day, then 20 mg/day. One sensitive user reports two days at 10 mg before increasing to 20 mg. Early benefit was followed by sleep disturbance and cold-like symptoms. The product's claimed liposomal form and actual exposure were not verified. Reddit r/HistamineIntolerance
Separate oral accounts: 100 mg daily and 250 mg twice daily. One MCAS commenter reports 100 mg once daily; the thread's author reports a product described as liposomal at 250 mg per use, 500 mg/day, alongside two other supplements. Neither amount defines a threshold for benefit. Reddit r/MCAS
A blend lists 150 mg luteolin, 75 mg rutin and 75 mg PEA. Its user reports once-daily, briefly twice-daily use. The 300 mg product title totals three ingredients; it is not 300 mg luteolin. Softgels per reported dose were unstated, so the daily component amounts remain unknown. Reddit r/MCAS
Another liposomal poster reports 400 mg; frequency is unstated. They describe an 800 mg two-capsule label. A reply reports no benefit up to 300 mg, with formulation and frequency unstated. More is not established as better. Reddit r/Supplements
Forum amounts also differ. Phoenix Rising's Hip reports about 80 mg daily and experiments up to 300 mg. Longecity's tintinet noticed no effect at 500 mg twice daily, 1,000 mg/day. Formulations were unstated. Phoenix Rising ME/CFS Forums Longecity Supplements forum
100–200 mg/day and about 300 mg remain in stack discussion. Existing notes give 100–200 mg/day capsule use. A NAD-stack note says 300 mg without frequency; a separate chart says 300 mg/day. Pairing with roughly 50 mg apigenin also appears. These do not establish consensus or a safe upper amount. Community

Half-life

No community-measured human supplement half-life. Daily use, a return of symptoms after stopping and a change in sleep do not measure how quickly luteolin leaves blood. These accounts provide no dependable clearance number for plain, liposomal or phytosome products; extract-study timing is separate context below. Community

Onset: when people notice a change

Two days in one diary; about a week for nasal relief. The 10 mg liposomal diary describes clarity during days 1–2; the allergy poster noticed improvement after about a week. A Biohackers commenter found no benefit after 1.5 months. These are different outcomes. Reddit r/HistamineIntolerance Reddit r/Supplements Reddit r/Biohackers

Duration: after a dose or stopping

Single-dose symptom coverage is unknown. The diarist describes restless sleep around day five and cold-like symptoms during days 5–12. Those symptoms faded the day after stopping and were gone within two days, while baseline MCAS symptoms returned. Recovery timing does not measure drug duration. Reddit r/HistamineIntolerance

Cycles and time off

Continuous use appears; no shared on/off calendar is established. After six weeks once daily, the blend user briefly doubled frequency after no longer noticing effects. By month three they reported benefit with once-nightly use because of daytime sleepiness. This does not establish a cycle. Reddit r/MCAS
PEA-LUT's eight-week course comes from a trial. A Long COVID poster followed circulated sublingual granules containing 700 mg PEA plus 70 mg luteolin per administration, twice daily: 1,400 mg PEA and 140 mg luteolin/day. This is a specific studied combination repeated by a user, not a luteolin-alone cycling rule. Reddit r/covidlonghaulers

Good to know

Natural does not mean free of reactions. One MCAS poster reports strong headache and worsening pain in neuropathy-affected areas after a first 100 mg dose despite generally tolerating quercetin. Existing notes also flag stomach upset and sedation. Product ingredients, underlying illness and co-use complicate attribution; initial improvement does not settle later tolerability. Personal report Community
Allergen source and the full ingredient list matter. Community cautions include peanut-shell-derived extracts, while the headache account used a product described as Sophora-derived. An extraction-source claim alone cannot establish allergen content or safety. Quercetin, vitamin C and other additions can further complicate reactions. Medication interactions and long-term supplement safety remain unresolved by these accounts. Community Personal report

What the experiences add

Better sleep and clearer daytime thinking are separate outcomes. The 100 mg MCAS commenter felt tired with morning use and slept better after moving it to night, yet reported no other improvement in their fatigue or brain fog. The blend user reported less edema, fog, appetite noise, cravings, gut swelling and allergies; later benefit and weight changes were confounded by added Zepbound. Reddit r/MCAS
Early PEA-LUT improvement did not become lasting recovery. Butterfly-331 reported more energy, focus and strength after three days and quicker recovery from a relapse. Another intense relapse followed within a week, with dizziness, headache and vision symptoms; some aches improved but other symptoms persisted. The later same-author reply says PEA-LUT did not change much. The initial excitement and later disappointment belong to one account. Reddit r/covidlonghaulers
Some forum users describe stimulation or returning pain. Phoenix Rising's invisiblejungle found a blend stimulating. Longecity's maxwatt reported hand and foot pain returning after initial relief during two weeks with resveratrol, then improvement within three days but residual knuckle stiffness. Phoenix Rising ME/CFS Forums Longecity Supplements forum
Timing and storage habits are practical conventions. Community notes place sedating apigenin combinations in the evening and NAD-oriented stacks in the morning, sometimes with a fat-containing meal. None establishes a superior clock or guaranteed absorption. Capsule notes describe dry, dark storage; injectable mixing instructions do not belong to these oral products. Community

What supporting research can clarify

The 2–3-hour elimination figure belongs to artichoke-extract research. The 14-person human study used extracts supplying 14.4 or 35.2 mg luteolin equivalents. Blood peaks appeared near 0.5 hours; recovered compounds were sulfate or glucuronide forms, not free luteolin. This extract-specific timing does not establish capsule effects or symptom duration. Official context
A PEA-LUT study does not isolate luteolin's benefit. The eight-week trial used the 700 mg PEA and 70 mg luteolin combination twice daily. Certain brain-stimulation measurements improved, but the cognitive screening tests did not show a significant treatment-by-time difference. That distinction limits claims of proven brain-fog recovery. Official context