STUDresearch · Non-peptide
Luteolin
Also known as
Luteolin flavonoid · 3',4',5,7-tetrahydroxyflavone · lutolin · CD38 luteolin · peanut-hull luteolin (discussed)
Community talk. May be wrong. Not medical advice. Not a protocol. Not for human or animal use.
Systemic oral flavonoid — a swallow. Not lutein, not a pin.
Days 1–2 at 10 mg felt clearer with less reactivity; after changing to 20 mg, restless sleep and then cold-like symptoms developed. The author's MAO/COMT explanation was speculative.
The title listed 60 softgels but did not establish softgels per reported dose. The user reported daytime sleepiness, later returned to once-nightly use, and added Zepbound by the month-three update.
Preserved as common standalone-capsule context; it is not a product-equivalence claim or an endorsed amount.
Preserved from NAD-stack discussion; the original note does not establish formulation or comparative exposure.
Half-life & effect duration
- Half-life in the body
- Total luteolin metabolites · oral extractAbout 2–3 hours
- Felt duration people report
- One accountClearer focus at first, then restless sleep and cold-like symptoms after increasing the amount
- Combination-product accountInitial sleepiness, followed by perceived benefit over months
Tap a line to jump into the full notes. Research only — may be wrong.
Timing context & sources
Half-life in the body
Total luteolin peaked within about 0.5 hours and had a reported 2–3 hour elimination half-life after either artichoke-leaf extract.
Luteolin was recovered only after deconjugation and circulated as sulfate or glucuronide metabolites rather than detectable free luteolin or intact glucoside.
Small healthy-volunteer study of glycoside-containing artichoke extracts; it does not establish PK for plain aglycone, liposomal, phytosome or combination supplements.
- Wittemer et al. — Bioavailability and pharmacokinetics of artichoke-leaf flavonoids (opens in a new tab)Fourteen-volunteer crossover study of extracts supplying 14.4 or 35.2 mg luteolin equivalents; total luteolin peak near 0.5 hours, biphasic elimination and 2–3 hour half-life reported for both extracts.Small study of luteolin glycosides within complex artichoke extracts; plasma and urine contained conjugates rather than free luteolin, limiting transfer to other supplements.
Felt duration people report
One report shifted from clearer focus at 10 mg to restless sleep and cold-like symptoms after 20 mg, while a combination-product user reported initial sleepiness and later perceived benefit over months.
The reports used different formulations and one product contained rutin and PEA; one user later added Zepbound.
Uncontrolled self-reports with unverified products, different co-ingredients and no objective mast-cell or sleep measurements.
- r/HistamineIntolerance — Reaction to liposomal luteolin (opens in a new tab)Original day-by-day report: 10 mg on days 1–2, 20 mg on days 3–5, restless sleep around day 5, cold-like symptoms through day 12, and symptom changes after stopping.Single uncontrolled account; product identity and liposomal exposure were not verified, and the author's MAO/COMT explanation was speculative.
- r/MCAS — Luteolin experiences and same-author update (opens in a new tab)A same-author comment reports once-daily use for six weeks then briefly twice daily and reproduces a product title listing 300 mg total, 150 mg luteolin, 75 mg rutin, 75 mg PEA and 60 softgels; a later update reports once-nightly use at month three and added Zepbound. The thread does not state softgels per dose.Combination product, unresolved serving unit, uncontrolled symptoms, changing frequency and later added medication; no verified capsule assay, daily luteolin amount or objective endpoints.
What people say
- NAD-sparing lore: CD38 inhibition in vitro/animal slides get copied next to apigenin. Human outcome data is thin. labanimalforum
- Mast-cell / “histamine brain” n=1s: Often louder than the NAD camp — less itch, less fog. Confounded by quercetin/vitamin C. anecdote
- PEA-LUT combo: Long-COVID / neuroinflammation posts copy ~700 mg PEA + 70 mg luteolin twice daily for ~8 weeks. That is a pair, not luteolin alone. forum
- Apigenin combo: People rarely run luteolin alone in 2026 NAD threads. forum
- What talk does not prove: A replacement for NMN, rapamycin, or a mast-cell clinic protocol. forum
Doses people talk about
- 100–200 mg/day: Common standalone capsule. forum
- 300 mg: Higher NAD-stack posts. forum
- With apigenin 50 mg-class rather than mega-luteolin alone. forum
- Phytosome bottles use lower milligrams and claim better uptake — not interchangeable with cheap powder. forum
- Framing: Supplement milligrams with terrible absorption — not a peptide. forum
How it may feel
- Days 1–7: One liposomal diary reported clearer focus and less allergic reactivity at 10 mg for two days, then restless sleep after moving to 20 mg; cold-like symptoms built from days 5–12. forum
- Weeks 1–12: A user of a combination product listing 150 mg luteolin, 75 mg rutin and 75 mg PEA reported once-daily use, briefly twice daily, early daytime sleepiness, several perceived benefits by six weeks and continued perceived benefit in a same-author month-three update. The thread did not establish the softgel count per reported dose. forum
- Felt effects conflict: Reports include daytime tiredness or better sleep, while a 10→20 mg liposomal diary described clearer focus first and later restless sleep. Products and co-ingredients differed. forum
Around the dose
- Clock: With apigenin, often evening if the pair makes them sleepy; morning if they treat it as NAD-sparing. forum
- Fat-containing meal for flavonoid uptake lore. forum
Cycles people discuss
- Daily with the NAD stack. forum
- Not a 5-on/2-off peptide calendar. forum
Timing
- CD38 talk is a chronic-intake story, not a 20-minute nootropic. forum
- Human oral extract PK: Total luteolin peaked at about 0.5 hours and showed a 2–3 hour elimination half-life; only sulfate or glucuronide metabolites, not free luteolin, were recovered. trial
More on what it is
- What most people mean: Apigenin’s cousin in the “block CD38 so NAD lasts” stack. forum
- Why it is here: 5-Amino-1MQ / apigenin / NAD threads treat luteolin as a second CD38/mast-cell lever. forum
- Bioavailability fight: Plain luteolin is poorly absorbed; “phytosome / luteolin+rutin / peanut-shell extracts” are the vendor answers. forum
- Not: Not lutein, not apigenin, not quercetin (close family, different diaries). forum
- What it is: A tetrahydroxyflavone in celery/peanut shells/herbs. Supplement milligrams. Not a peptide. trial
Stacks
- + Apigenin: The CD38 pair. forum
- + NMN / NR / NAD+: Spare-the-pool story. forum
- + Quercetin / vitamin C: Mast-cell drawer. forum
- + Fisetin: Longevity flavone pile-on. forum
Access talk
- OTC flavonoid. Not a 503A peptide. forum
Storage notes
- Capsules, dry, dark. forum
- Not BAC water. forum
Watch for
- Name mix-up with lutein. forum
- GI / sedation. forum
- Poor absorption — high milligrams on a cheap bottle may still be a small exposure. forum
- Allergy caution on peanut-shell sourced extracts. forum