Non-peptide

Pyrilutamide

Also known as

KX-826 · KX826 · Kintor topical AR antagonist · pyrilutamide 0.5% · pyrilutamide 1%

Community talk. May contain inaccuracies. Not medical advice. Not a protocol. Not for human or animal use.

What it is

Identity	KX-826 is a topical androgen-receptor blocker discussed for pattern hair loss. It acts at the receptor, while finasteride and dutasteride reduce DHT formation.
Role in hair routines	People seek maintenance, regrowth or an alternative after finasteride side effects. The accounts concern scalp liquids and sprays, with minoxidil working through a different mechanism.

Notes

Pyrilutamide (KX-826) is a topical androgen-receptor blocker discussed for pattern hair loss. People seek less shedding, thicker hair or an alternative after finasteride side effects. Reports include regrowth, no visible change and reasons to stop; the bottle and accompanying treatments matter.

A scalp androgen blocker. Pyrilutamide, also called KX-826, is a nonsteroidal small molecule. It aims to stop androgen signals at the hair follicle's receptor. Finasteride and dutasteride instead reduce formation of DHT, an androgen involved in pattern hair loss. Minoxidil supports growth through a different mechanism. Kintor — FY2025 results announcement filed March 2026 (Official context · Accessed 2026-09-30)

A topical alternative or add-on. Hair-loss communities look for maintenance or regrowth when finasteride caused unwanted effects, or when minoxidil alone stopped holding ground. Reports discuss scalp liquids and sprays; this is not an oral or injected regimen. r/tressless — 29M seven-month pyrilutamide update (Community discussion · Accessed 2026-09-30) · r/tressless — What I've learned from eight months on Pyrilutamide (Community discussion · Accessed 2026-09-30)

Source context — Kintor — FY2025 results announcement filed March 2026: Manufacturer-authored regulatory disclosure, not regulator endorsement. March 2026 topline repeated here shares press source family. No beyond-one-year safety inference.

Source context — r/tressless — 29M seven-month pyrilutamide update: Anonymous uncontrolled reports; images not independently measured; minoxidil and tretinoin co-use. Deleted replies not inspected.

Source context — r/tressless — What I've learned from eight months on Pyrilutamide: Same author's longitudinal claims are one account, not independent corroboration. Concentration-switch date unknown. Assertions about perfect coverage, degradation and required one-hour spacing unverified.

What people notice

Shedding and itch	Some describe less shedding or rapid scalp-itch relief. Those sensations do not establish that follicles are recovering.
Hair coverage	One seven-month user reported new coverage after adding KX-826 to longstanding minoxidil. Another saw no change after five months of 0.5% twice daily on one temple.
Mixed longer logs	One eight-month author described thicker surviving hairs alongside repeated sheds and a foam-related setback. Minoxidil and other scalp treatments continued, so the cause of each change is unclear.

Notes

Less shedding or scalp itch. Some users describe quick itch relief and fewer hairs falling out. Those sensations do not measure whether follicles are recovering. One three-week account reported both modest benefit and substantial physical symptoms. r/tressless — My experience with Pyrilutamide (Personal report · Accessed 2026-09-30)

Thicker existing hair, with mixed results. A seven-month author described new coverage after adding KX-826 to longstanding minoxidil. In the same thread, another person saw no difference after five months treating one temple with 0.5% twice daily. Neither account isolates the compound's effect. r/tressless — 29M seven-month pyrilutamide update (Community discussion · Accessed 2026-09-30)

Better photos can still involve several treatments. The 2026 eight-month author reported two sheds, thicker surviving hairs, worsening during six weeks on foam and improvement after returning to spray. Minoxidil, alfatradiol and shampoo continued. Their explanation that foam or storage caused the setback was not tested. r/tressless — What I've learned from eight months on Pyrilutamide (Community discussion · Accessed 2026-09-30)

Source context — r/tressless — My experience with Pyrilutamide: Stated 5% identity/concentration unverified and not silently corrected to 0.5%; not used as ordinary dose band. RU substitution is reply speculation. No denominator or causal confirmation.

Doses people talk about

0.5% topical accounts	Once-daily and twice-daily use appear. One stacked-treatment log states 1 mL of 0.5% once nightly; concentration alone does not establish the amount applied.
Other strengths and sprays	Separate authors report 1% daily, a later switch from 0.5% to 0.9% daily, or 5–7 morning sprays without calibrated volume. These are distinct formulations and accounts.
Unverified 5% adverse account	One three-week adverse report explicitly states 5% solution at 0.25–0.5 mL/day. That reported label is separate from the 0.5% logs and was not independently verified.

Notes

0.5% once daily or twice daily; 1% also appears. A six-person group report described mostly 0.5% daily and one person's 1% daily use. A different stacked-treatment log specified 1 mL of 0.5% once nightly. Concentration, liquid volume and frequency are separate details; the first report did not establish an applied daily mass. r/tressless — No side effects on pyrilutamide / KX-826 so far (Community discussion · Accessed 2026-09-30) · r/tressless — Six months topical fin/min, three months pyrilutamide (Personal report · Accessed 2026-09-30)

Spray counts are not milligram amounts. The seven-month author described about 5–7 sprays each morning without a calibrated volume. A 2026 author moved from 0.5% to 0.9%, once daily, but could not date the switch precisely. These are separate formulations and accounts, not an escalation guide. r/tressless — 29M seven-month pyrilutamide update (Community discussion · Accessed 2026-09-30) · r/tressless — What I've learned from eight months on Pyrilutamide (Community discussion · Accessed 2026-09-30)

Opening post by Ok_Count8131: three weeks, stated 5% solution 0.25–0.5 mL/day, itch relief up to 12 hours, reduced sebum/shedding, chest/breathing/palpitations symptoms and recovery after one week; replies Clean-Birthday-1630, SizeBig543 and Sekcross. r/tressless — My experience with Pyrilutamide (Personal report · Accessed 2026-09-30)

Chest symptoms are not evidence of useful activity. The three-week account included chest pain, breathlessness, palpitations and reduced exercise tolerance. Product identity and causation were unverified. Other replies reported no such symptoms or headaches and itching without hair improvement; this thread cannot estimate risk. r/tressless — My experience with Pyrilutamide (Personal report · Accessed 2026-09-30)

Source context — r/tressless — No side effects on pyrilutamide / KX-826 so far: One poster relays five others, not six independently inspected authors. Claimed lab result not verified. No formulation recipe reproduced.

Source context — r/tressless — Six months topical fin/min, three months pyrilutamide: Highly confounded stack. Other ingredients and self-formulation are not copied as instructions.

Half-life, onset & duration

Felt onset	Itch relief was immediate in one account. A different user described shedding around days 30–40 followed by improvement over months while continuing minoxidil; early shedding does not prove benefit.
Felt duration	One adverse-account author described up to about 12 hours of itch relief. Most hair logs continue treatment, so persistence after stopping remains uncertain.
Half-life	The 48-hour forum question and secondhand two-hour skin claim provide no primary measurement. Neither establishes human blood or scalp half-life.

Notes

Itch relief can precede any hair change. One user described relief on application; an older five-month photo-thread summary described almost immediate itch and shedding improvement. That is a symptom report, not instant regrowth. r/tressless — My experience with Pyrilutamide (Personal report · Accessed 2026-09-30)

A shed around days 30–40, then improvement over months. This was the seven-month author's timeline while continuing minoxidil. The early group report described only fine, soft hairs at six weeks, without thick-hair results. Early shedding differs between accounts and is not proof that treatment is working. r/tressless — 29M seven-month pyrilutamide update (Community discussion · Accessed 2026-09-30) · r/tressless — No side effects on pyrilutamide / KX-826 so far (Community discussion · Accessed 2026-09-30)

Up to roughly 12 hours of itch relief in one account. The three-week user estimated this window, then stopped because of chest and breathing symptoms and reported feeling normal a week later. Neither the relief nor recovery interval measures drug half-life. r/tressless — My experience with Pyrilutamide (Personal report · Accessed 2026-09-30)

Persistence after stopping remains uncertain. Most logs continue treatment. A Spanish user reported benefit, then inconsistent bottle response and renewed loss while on finasteride and oral minoxidil. Heat degradation was their untested theory. Recuperar El Pelo — Pyrilutamide discussion, nyss update (Personal report · Accessed 2026-09-30)

48 hours is a forum question, not a measured value. A microneedling thread contains a comment asking whether the half-life is 48 hours, without supporting data. It does not establish how long pyrilutamide remains in human blood or scalp. r/tressless — Microneedling and Pyrilutamide (Secondhand community claim · Accessed 2026-09-30)

About 2 hours in skin is another secondhand claim. A 2026 Reddit reply attributes this estimate to Grokipedia, alongside trial-summary claims; another reply questions whether AI supplied the answer. No primary measurement is shown there. Neither claim settles human half-life, and application frequency cannot resolve it. r/tressless — Has systemic absorption data been published? (Secondhand community claim · Accessed 2026-09-30)

Source context — Recuperar El Pelo — Pyrilutamide discussion, nyss update: Spanish post read in context; translated paraphrase, not quotation. Bottle chemistry not tested; dose concentration absent. One repeated author's history.

Source context — r/tressless — Microneedling and Pyrilutamide: Question rather than a measured number; no linked data. Microneedling comments and unsupported hormonal claims do not establish safety or absorption.

Source context — r/tressless — Has systemic absorption data been published?: Secondhand summary, not primary human measurement; source origin is Grokipedia claim, not independently verified. Declines its no-accumulation safety inference.

Cycles people discuss

Continued maintenance	Six-week, seven-month and eight-month logs, plus older 6–12-month use, describe follow-up periods. They do not establish a safe course length or a standard on/off cycle.
Reduced frequency	One author recalled renewed loss after cutting to weekly use, later improvement at twice weekly, then another setback while using other hair treatments. That history is not a repeat calendar.

Notes

Months of logs describe maintenance, not a settled cycle. Six-week, seven-month and eight-month accounts report repeated topical use. The older card describes continued use over 6–12 months. These follow-up windows do not establish a safe course length or a standard break-and-restart schedule. r/tressless — No side effects on pyrilutamide / KX-826 so far (Community discussion · Accessed 2026-09-30) · r/tressless — 29M seven-month pyrilutamide update (Community discussion · Accessed 2026-09-30) · r/tressless — What I've learned from eight months on Pyrilutamide (Community discussion · Accessed 2026-09-30)

Reduced frequency has a mixed history. The Spanish author recalled renewed loss after reducing to once weekly, then benefit with two weekly applications before another setback while continuing other hair treatments. This is one confounded timeline, not a repeat calendar. Recuperar El Pelo — Pyrilutamide discussion, nyss update (Personal report · Accessed 2026-09-30)

Stacks

Hair-treatment combinations	Oral or topical minoxidil, finasteride, dutasteride and microneedling recur. Better photos during several treatments cannot isolate pyrilutamide's contribution.
RU comparisons	RU-58841 is mostly compared with or replaced by pyrilutamide in the saved notes. Patent or mouse comparisons do not establish superior human results or a checked combination.

Notes

Minoxidil: Oral or topical minoxidil accompanies several reports, making changes in hair coverage difficult to attribute to pyrilutamide alone. [community]

Finasteride or dutasteride: Reports describe addition to, or substitution for, a 5-AR inhibitor. These are different treatment histories, not evidence of combination safety. [community]

Microneedling: It appears in some hair-treatment routines and adds uncertainty about irritation and treatment attribution. These reports do not establish a safe combination. [community]

RU comparisons: RU is discussed mainly as an alternative in the saved notes; this does not establish a combined regimen. [community]

RU comparisons mix hopes with evidence. A HairLossTalk post promoted pyrilutamide using patent binding claims and mouse hair-growth results; these do not establish superior human results. An early group poster relayed six people without adverse effects at six weeks, including prior finasteride or RU intolerance. That is one relay, not six verified independent logs. HairLossTalk — Kintor's Pyrilutamide outcompetes RU-58841? (Community opinion · Accessed 2026-09-30) · r/tressless — No side effects on pyrilutamide / KX-826 so far (Community discussion · Accessed 2026-09-30)

Source context — HairLossTalk — Kintor's Pyrilutamide outcompetes RU-58841?: Patent-derived laboratory and animal claims are the actual origin, not human effectiveness evidence. Patent identity inference not independently adjudicated; first page only.

Watch for

Whole-body symptoms	Accounts include lower libido, nipple sensitivity and finasteride-like symptoms. One unverified 5%-label account describes chest pain, breathlessness and palpitations; that is not evidence of useful activity.
Scalp irritation	Dryness, stinging, itching and flaking occur. Alcohol or propylene glycol and other scalp treatments can affect tolerability; keep scalp products away from children and pets.
Bottle uncertainty	Purity claims cannot verify another person's bottle. Heat damage, incorrect concentration or substitution with RU are proposed explanations in threads, rather than established causes of nonresponse or symptoms.

Notes

Topical does not mean symptom-free. An early commenter reported finasteride- or dutasteride-like symptoms after about a week, continuing for three weeks during use and resolving five days after stopping. The older record also includes low libido and nipple sensitivity on 0.5% twice daily; these reports do not prove systemic absorption or its amount. r/tressless — Does pyrilutamide cause short-term shedding? (Community discussion · Accessed 2026-09-30)

The liquid base and other treatments matter. Dryness, stinging, itching and flaking appear in accounts. Alcohol or propylene glycol may complicate tolerability. Microneedling, minoxidil, finasteride and dutasteride also appear in stacks; these combinations lack a demonstrated interaction or long-term safety profile in these reports. Keep scalp products away from children and pets. r/tressless — What I've learned from eight months on Pyrilutamide (Community discussion · Accessed 2026-09-30) · r/tressless — Six months topical fin/min, three months pyrilutamide (Personal report · Accessed 2026-09-30)

Bottle uncertainty does not explain every nonresponse. The five-month nonresponder offered several possibilities: product identity, concentration, personal response or insufficient time. No possibility was established. Likewise, a reassuring group-buy purity claim does not verify another person's bottle, and an adverse account cannot prove substitution with RU. r/tressless — 29M seven-month pyrilutamide update (Community discussion · Accessed 2026-09-30) · r/tressless — No side effects on pyrilutamide / KX-826 so far (Community discussion · Accessed 2026-09-30) · r/tressless — My experience with Pyrilutamide (Personal report · Accessed 2026-09-30)

Source context — r/tressless — Does pyrilutamide cause short-term shedding?: Same commenter benefit, reaction and recovery remain one account. Symptoms not clinically evaluated; systemic explanation is their inference.

Source context — r/tressless — Six months topical fin/min, three months pyrilutamide: Highly confounded stack. Other ingredients and self-formulation are not copied as instructions.

Full notes

What it is and why people try it

A scalp androgen blocker. Pyrilutamide, also called KX-826, is a nonsteroidal small molecule. It aims to stop androgen signals at the hair follicle's receptor. Finasteride and dutasteride instead reduce formation of DHT, an androgen involved in pattern hair loss. Minoxidil supports growth through a different mechanism. Official context
A topical alternative or add-on. Hair-loss communities look for maintenance or regrowth when finasteride caused unwanted effects, or when minoxidil alone stopped holding ground. Reports discuss scalp liquids and sprays; this is not an oral or injected regimen. Reddit Reddit Community

What people hope to notice

Less shedding or scalp itch. Some users describe quick itch relief and fewer hairs falling out. Those sensations do not measure whether follicles are recovering. One three-week account reported both modest benefit and substantial physical symptoms. Personal report
Thicker existing hair, with mixed results. A seven-month author described new coverage after adding KX-826 to longstanding minoxidil. In the same thread, another person saw no difference after five months treating one temple with 0.5% twice daily. Neither account isolates the compound's effect. Reddit

Doses people discuss

0.5% once daily or twice daily; 1% also appears. A six-person group report described mostly 0.5% daily and one person's 1% daily use. A different stacked-treatment log specified 1 mL of 0.5% once nightly. Concentration, liquid volume and frequency are separate details; the first report did not establish an applied daily mass. Reddit Personal report
Spray counts are not milligram amounts. The seven-month author described about 5–7 sprays each morning without a calibrated volume. A 2026 author moved from 0.5% to 0.9%, once daily, but could not date the switch precisely. These are separate formulations and accounts, not an escalation guide. Reddit Reddit

Half-life

48 hours is a forum question, not a measured value. A microneedling thread contains a comment asking whether the half-life is 48 hours, without supporting data. It does not establish how long pyrilutamide remains in human blood or scalp. Reddit
About 2 hours in skin is another secondhand claim. A 2026 Reddit reply attributes this estimate to Grokipedia, alongside trial-summary claims; another reply questions whether AI supplied the answer. No primary measurement is shown there. Neither claim settles human half-life, and application frequency cannot resolve it. Reddit

Onset: when changes are noticed

Itch relief can precede any hair change. One user described relief on application; an older five-month photo-thread summary described almost immediate itch and shedding improvement. That is a symptom report, not instant regrowth. Personal report Community
A shed around days 30–40, then improvement over months. This was the seven-month author's timeline while continuing minoxidil. The early group report described only fine, soft hairs at six weeks, without thick-hair results. Early shedding differs between accounts and is not proof that treatment is working. Reddit Reddit

Duration: how long changes last

Up to roughly 12 hours of itch relief in one account. The three-week user estimated this window, then stopped because of chest and breathing symptoms and reported feeling normal a week later. Neither the relief nor recovery interval measures drug half-life. Personal report
Persistence after stopping remains uncertain. Most logs continue treatment. A Spanish user reported benefit, then inconsistent bottle response and renewed loss while on finasteride and oral minoxidil. Heat degradation was their untested theory. Personal report

Cycles and continuing use

Months of logs describe maintenance, not a settled cycle. Six-week, seven-month and eight-month accounts report repeated topical use. The older card describes continued use over 6–12 months. These follow-up windows do not establish a safe course length or a standard break-and-restart schedule. Reddit Reddit Reddit Community
Reduced frequency has a mixed history. The Spanish author recalled renewed loss after reducing to once weekly, then benefit with two weekly applications before another setback while continuing other hair treatments. This is one confounded timeline, not a repeat calendar. Personal report

What to watch for

Topical does not mean symptom-free. An early commenter reported finasteride- or dutasteride-like symptoms after about a week, continuing for three weeks during use and resolving five days after stopping. The older record also includes low libido and nipple sensitivity on 0.5% twice daily; these reports do not prove systemic absorption or its amount. Reddit Community
Chest symptoms are not evidence of useful activity. The three-week account included chest pain, breathlessness, palpitations and reduced exercise tolerance. Product identity and causation were unverified. Other replies reported no such symptoms or headaches and itching without hair improvement; this thread cannot estimate risk. Personal report
The liquid base and other treatments matter. Dryness, stinging, itching and flaking appear in accounts. Alcohol or propylene glycol may complicate tolerability. Microneedling, minoxidil, finasteride and dutasteride also appear in stacks; these combinations lack a demonstrated interaction or long-term safety profile in these reports. Keep scalp products away from children and pets. Reddit Personal report Community

Separate trial context

Company results concern controlled trial products. Kintor reported 24-week hair-count increases of 15.33 hairs/cm² with 1% twice daily, 14.46 with 0.5% twice daily, and 4.68 with vehicle in 666 Chinese men. These topline figures do not prove the strengths equivalent or verify community bottles. Official context
52 weeks belongs to a different study. Kintor's filing describes a separate open-label 0.5% safety study. A positive trial announcement is not FDA approval or proof of indefinite safety. Official context

What actual use adds to the picture

Better photos can still involve several treatments. The 2026 eight-month author reported two sheds, thicker surviving hairs, worsening during six weeks on foam and improvement after returning to spray. Minoxidil, alfatradiol and shampoo continued. Their explanation that foam or storage caused the setback was not tested. Reddit
TRT and steroid comparisons remain uncertain. The older account records no visible change with 0.5% once daily alongside testosterone 120 mg/week. Discussion blames androgen exposure or frequency, but neither explanation was measured. Other hair stacks include microneedling and oral or topical minoxidil. Community Personal report
RU comparisons mix hopes with evidence. A HairLossTalk post promoted pyrilutamide using patent binding claims and mouse hair-growth results; these do not establish superior human results. An early group poster relayed six people without adverse effects at six weeks, including prior finasteride or RU intolerance. That is one relay, not six verified independent logs. HairLossTalk Reddit
Bottle uncertainty does not explain every nonresponse. The five-month nonresponder offered several possibilities: product identity, concentration, personal response or insufficient time. No possibility was established. Likewise, a reassuring group-buy purity claim does not verify another person's bottle, and an adverse account cannot prove substitution with RU. Reddit Reddit Personal report