Peptide

Selank analogs / TP-7 variants

Also known as

TP-7 · TP7 variants · Selank family · Selank (TP-7) · Selanc · Селанк · Thr-Lys-Pro-Arg-Pro-Gly-Pro family · TKPRPGP family · N-Acetyl Selank · N-Acetyl Selank Amidate · NA-Selank / NA-Selank Amidate · Ac-Thr-Lys-Pro-Arg-Pro-Gly-Pro-NH2 (dual-capped form) · tuftsin + Pro-Gly-Pro heptapeptide family

Community talk. May contain inaccuracies. Not medical advice. Not a protocol. Not for human or animal use.

What it is

Selank and modified forms	Selank, or TP-7, is a seven-amino-acid peptide discussed for anxiety and calm focus. N-acetyl Selank and N-acetyl Selank Amidate are distinct chemical modifications.
Labels and routes matter	Acetate names a salt; amidate names an end modification. They are different terms. Nasal sprays dominate the accounts, with separate injection reports.

Notes

Selank, also called TP-7, is a synthetic peptide discussed for quieter anxiety and calmer focus. N-acetyl Selank and N-acetyl Selank Amidate modify the parent peptide, but reports do not establish which form works best. Some people feel calmer; others notice nothing, detachment or increased anxiety.

Plain Selank is the seven-amino-acid peptide TKPRPGP. It extends tuftsin, a natural immune-related peptide, with three amino acids. N-acetyl adds a chemical cap at one end; amidation changes the other end. N-acetyl Selank and N-acetyl Selank Amidate therefore name distinct modifications, not interchangeable labels. Volkova et al.: Selank and GABA-related gene expression (Animal context · Accessed 2026-09-30)

“Acetate” and “amidate” mean different things. Acetate describes a salt formulation; amidate refers to the peptide’s end modification. A product called N-acetyl Selank Amidate Acetate can contain both descriptions. Nasal sprays dominate these discussions; SubQ means injection beneath the skin. Semax & Selank not working. Am I missing something? (Community discussion · Accessed 2026-09-30)

Source context — Volkova et al.: Selank and GABA-related gene expression: Parent-peptide rat molecular endpoints. Introduction summarizes earlier clinical claims but is not a clinical comparison of modified forms. No human dose or variant PK derived here.

Source context — Semax & Selank not working. Am I missing something?: Self-reported spray labels; timing of all three Selank comparisons is incompletely described. Some comments deleted; no verified chemistry, blinding or reason for nonresponse. Semax adverse claims are not automatically Selank claims.

What people notice

A quieter mind, or no relief	Some responders describe less rumination, social tension and background anxiety. Other users notice nothing, detachment or increased anxiety.
No settled best form	One commenter found the analogues alike; another preferred N-acetyl over plain or amidated forms. 'Dual-capped is strongest' is a community hypothesis, not a demonstrated ranking.

Notes

Less rumination, social tension and background anxiety. Responders describe a quieter mind rather than a high. Calm focus and steadier emotional reactions are the appeal, but the same family also produces no change, detachment or more anxiety in other reports. DSIP + N-acetyl Selank (Personal report · Accessed 2026-09-30) · Semax & Selank not working. Am I missing something? (Community discussion · Accessed 2026-09-30) · Review of Selank Acetate and N-Acetyl-Selank (Community discussion · Accessed 2026-09-30)

A more stable form does not guarantee a better experience. One commenter found all Selank analogues alike; another preferred N-acetyl over plain and amidated. The claim that dual capping makes it strongest remains a community hypothesis, not a demonstrated ranking. Any experiences with Selank/Semax analogues? (Community discussion · Accessed 2026-09-30) · Selank info (Community discussion · Accessed 2026-09-30) · different versions of selank/semax (Secondhand community claim · Accessed 2026-09-30)

Source context — DSIP + N-acetyl Selank: Short early-course observation with multiple exposures, unverified product and no component isolation. Do not repeat inconsistent TRT units or credit libido/sleep results solely to Selank.

Source context — Review of Selank Acetate and N-Acetyl-Selank: OP retains mg labels even though a reply challenges the units; the mix-up amount is unusable as a reliable numeric dose. Friend report is secondhand. Opioid history, uncertain products and absent controlled withdrawal assessment limit the commenter.

Source context — Any experiences with Selank/Semax analogues?: No blinded comparison; dose report does not specify route/form. Same Jalex1984 username also occurs in s2i9gb, so not counted as an independent extra user. Semax-specific duration/sleep claims excluded from Selank timing.

Source context — Selank info: Multiple commenters, some usernames deleted. 200–300 mcg nasal frequency is described in commercial-source context. SubQ form unspecified. Antiviral anecdotes and emergency-stroke suggestion do not establish disease treatment.

Source context — different versions of selank/semax: Evidence of circulating belief and confusion only; no measured kinetics or Selank comparison. Semax euphoria/onset/duration not transferred to Selank.

Doses people talk about

Plain nasal discussion	250–900 mcg/day split one to three times recurs. Separate reports use 250–500 mcg per administration once or twice daily; those per-use amounts are not the same as daily totals.
N-acetyl and amidate accounts	One nasal user found little benefit at N-acetyl 300 mcg, plain 400 mcg and N-acetyl amidate 200 mcg per administration. Another positive N-acetyl account used 250 mcg each morning.
Commercial capped-form charts	Charts list 100–300 mcg per pump, often 300 mcg two or three times daily: 600–900 mcg/day. Separate 'more potent' claims propose 150–300 mcg/day, without validated equivalence.
Injection reports	One person describes 175–225 mcg beneath the skin twice daily: 350–450 mcg/day, form unspecified. Other injection charts differ; no nasal-to-injection conversion is established.

Notes

Plain nasal discussions: 250–900 mcg/day, split one to three times. The original record also contains 200–300 mcg/day, separate 250–500 mcg administrations once or twice daily, and 300 mcg administrations two or three times daily. Higher discussions reach 600–1,200+ mcg/day; individual logs include 500–600 mcg/day for months or about 1 mg/day short runs. These are not one dose ladder.

N-acetyl and amidate sprays: amounts and outcomes differ. One nasal user reported little benefit from N-acetyl 300 mcg, plain 400 mcg and N-acetyl amidate 200 mcg administrations. Another N-acetyl user tried 200 mcg once or twice daily and 400 or 550 mcg once daily with minimal change and uncertain eye strain or twitching. Semax & Selank not working. Am I missing something? (Community discussion · Accessed 2026-09-30) · NA-Selank experiences and odd effects from higher dosages (Community discussion · Accessed 2026-09-30)

Capped-form charts are commercial discussion, not validated equivalents. The original charts list 100–300 mcg per pump, commonly 300 mcg two or three times daily, totaling 600–900 mcg/day. Separate “more potent” claims propose 150–300 mcg/day. A positive N-acetyl account used 250 mcg nasal each morning; a LongeCity stack lists 300 mcg/day without a route. DSIP + N-acetyl Selank (Personal report · Accessed 2026-09-30) · Cognito member stack (Community guide · Accessed 2026-09-30)

SubQ reports need their own amounts. One person describes 175–225 mcg per injection twice daily, totaling 350–450 mcg/day, with unspecified form. Original injection talk includes 150–250 mcg/day, a separate 200–500 mcg/day band, and commercial 0.5 mg charts. None establishes a nasal-to-injection conversion. Selank info (Community discussion · Accessed 2026-09-30)

Source context — NA-Selank experiences and odd effects from higher dosages: OP has little baseline anxiety and describes poor response to other nootropics. Commenter units, precise molecule and route are incomplete; do not silently convert their 750 to a verified mcg N-acetyl exposure.

Source context — Cognito member stack: User-created stack, not a controlled experience report. Route omitted; no outcome, comparative efficacy or measured half-life.

Half-life, onset & duration

Felt onset	Original nasal reports describe 15–60 minutes, immediate calm or gradual response. One N-acetyl account gives about two hours, rather than the earlier window.
Felt duration	Older nasal summaries describe 3–6 hours of calm. One N-acetyl user reports about seven hours; another four hours of detachment. A separate 200 mcg N-acetyl exposure brought 2–3 hours of anxiety.
Half-life	No dependable human nasal-variant half-life is established. Commercial claims of 10–20 minutes in plasma and a 4–6-hour 'effective window' describe different, unverified ideas.

Notes

15–60 minutes nasal is an original reported window; some notice nothing. Other accounts describe immediate calm or a gradual course response. One N-acetyl nasal reporter places onset around two hours. Original SubQ talk says 15–30 minutes, but lacks a reliable form-specific comparison. These are separate impressions, not absorption measurements. Selank info (Community discussion · Accessed 2026-09-30) · DSIP + N-acetyl Selank (Personal report · Accessed 2026-09-30)

Hours of calm and hours of discomfort are different outcomes. Original nasal summaries describe 3–6 hours of calm. One N-acetyl spray report describes about seven hours after a two-hour onset; another describes four hours of detachment. A 200 mcg N-acetyl exposure instead brought two-to-three hours of increased anxiety. DSIP + N-acetyl Selank (Personal report · Accessed 2026-09-30) · Review of Selank Acetate and N-Acetyl-Selank (Community discussion · Accessed 2026-09-30) · Selank causing/amplifying anxiety? (Personal report · Accessed 2026-09-30)

No dependable human half-life for these nasal variants was established here. One thread asks whether caps extend half-life but supplies no measurement. Original commercial lore separately claims 10–20 minutes in plasma and a 4–6-hour “effective window.” The latter describes presumed effects, not elimination; neither is a verified human N-acetyl amidate half-life. different versions of selank/semax (Secondhand community claim · Accessed 2026-09-30)

Source context — Selank causing/amplifying anxiety?: Single uncontrolled exposure; cannabis mentioned as usual coping, not confirmed concurrent ingestion. Initial mg typo corrected by author. No validated product identity or causal mechanism.

Cycles people discuss

Courses and as-needed use	Two-to-four-week courses coexist with high-stress-day use. Other patterns include 14–21 days, one month on/one off and weekdays on/weekends off, without a tested repeat interval.
Modified-form guide	A two-week capped-form course with one week off comes from commercial sample guides. Switching forms or reporting no classic benzodiazepine withdrawal does not establish tolerance prevention.

Notes

Two-to-four-week courses and as-needed use coexist. Original community patterns include 14–21 days, one month on/one month off, two-to-four weeks on with similar time off, and weekdays on/weekends off. A forum commenter proposes no more than 30 days once or twice yearly; that is their rule of thumb, not a tested interval. Selank info (Community discussion · Accessed 2026-09-30)

A two-week capped-form course with a week off comes from sample guides. That commercial calendar differs from occasional high-stress-day use or repeat courses around travel/exams. Intermittent long-term reports also exist. Switching forms between cycles and absence of classic benzodiazepine withdrawal do not establish tolerance prevention or safe long-term use. Selank info (Community discussion · Accessed 2026-09-30)

Stacks

Semax plus Selank	The calm-focus pair is usually separately dosed, not a fixed ratio. Sample charts give Semax 100–200 mcg plus Selank 250 mcg in the morning, or Semax morning/Selank evening.
Modified pair and other nootropics	N-acetyl Selank Amidate plus N-acetyl Semax Amidate appears in stack talk. Noopept, caffeine, theanine and racetams also recur, without established combination safety.
Sleep and larger stacks	The seven-hour calm account also involved bedtime DSIP and TRT. Another N-acetyl stack included memantine and phenylpiracetam hydrazide.

Notes

The “calm focus” stack makes credit difficult. Semax plus Selank is often two separately dosed products, not a fixed ratio. The original charts include Semax 100–200 mcg plus Selank 250 mcg in the morning, or Semax 200–300 mcg morning and Selank 250–500 mcg evening. They remain commercial examples, not synergy evidence.

Stabilized dual pair: N-Acetyl Selank Amidate + N-Acetyl Semax Amidate (NASA) — same typology with modified analogs when users want longer perceived duration or different spray stock. [community]

Other ingredients can change the story. Noopept, caffeine, L-theanine, racetams, magnesium, adaptogens, DSIP and other cognitive peptides recur. The seven-hour calm report includes bedtime DSIP and TRT. LongeCity’s N-acetyl stack includes memantine and phenylpiracetam hydrazide. Original solo-first sequencing spans five-to-seven days, a discussion habit rather than a validated rule. DSIP + N-acetyl Selank (Personal report · Accessed 2026-09-30) · Cognito member stack (Community guide · Accessed 2026-09-30)

Combination and long-term safety are unresolved. There is no reassuring interaction map for psychiatric medicines, alcohol or peptide stacks. Pregnancy, breastfeeding and immune-condition cautions remain; autoimmune effects are theoretical. “Non-sedating” claims cannot establish driving fitness, medication equivalence or a reason to change prescribed treatment. Selank causing/amplifying anxiety? (Personal report · Accessed 2026-09-30)

Source context — Cognito member stack: User-created stack, not a controlled experience report. Route omitted; no outcome, comparative efficacy or measured half-life.

Watch for

More anxiety or worse sleep	One user estimated 400 mcg/day nasally, briefly 600, without relief and with worsening insomnia. Sleep improved gradually after stopping, amid longstanding symptoms and other treatments.
Irritation and unwanted dulling	Reports include nasal burning or dryness, headache, dizziness, fatigue and emotional flatness. Injection redness belongs to a separate route; reaction rates are unknown.
Quality and immune reactions	Form labels and delivered amounts can be uncertain. FDA flags possible immune reactions, aggregation and peptide impurities for compounded Selank acetate.
Withdrawal and interaction claims	One N-acetyl amidate commenter described mild withdrawal after running out; that does not establish an opioid mechanism. Psychiatric-medication, alcohol and long-term combination safety remain unresolved.

Notes

More anxiety or worse sleep can occur despite the calming reputation. An intranasal user estimated 400 mcg/day, briefly 600, without relief and with worsening insomnia. Sleep gradually improved after stopping, but longstanding anxiety, sleep problems and later sleep medicines complicate causality. Paradoxical insomnia/anxiety reaction to Selank? (Personal report · Accessed 2026-09-30)

Irritation and unwanted dulling also appear. Original reports include nasal burning, dryness, sneezing, runny nose or throat drip; headache, head pressure, dizziness, fatigue and emotional flatness. Less frequent notes describe irritability, vivid dreams, nausea, hot/cold sensations or heart-rate awareness. Injection-site redness is separate. Their frequency and causes are uncertain. Review of Selank Acetate and N-Acetyl-Selank (Community discussion · Accessed 2026-09-30)

Product identity and immune reactions remain concerns. Incorrect form labels, uncertain delivered amounts, degradation and contamination complicate reports. FDA flags aggregation, peptide impurities and possible immunogenicity for compounded Selank acetate. Its withdrawn nomination does not resolve those concerns. FDA: Certain bulk drug substances that may present significant safety risks (Official context · Accessed 2026-09-30)

“No withdrawal” is disputed personal language. A reviewer denied an opioid-like feel, while a commenter with long-term opioid use described that feel and mild withdrawal after N-acetyl amidate ran out. Another reports a brief distant, weak-body reaction after an accidental amount, with units/form incomplete. These accounts prove neither an opioid mechanism nor freedom from dependence. Review of Selank Acetate and N-Acetyl-Selank (Community discussion · Accessed 2026-09-30) · NA-Selank experiences and odd effects from higher dosages (Community discussion · Accessed 2026-09-30)

Source context — Paradoxical insomnia/anxiety reaction to Selank?: Exact variant not named. Delivered spray amount estimated; preparation instructions excluded. Baseline illness, other agents and later sleep treatment confound attribution.

Source context — FDA: Certain bulk drug substances that may present significant safety risks: Compounding risk statement for Selank acetate, not a quantified event rate or a specific evaluation of every capped analog. Withdrawn nomination is not a safety clearance.

Full notes

What TP-7 and the variants mean

Plain Selank is the seven-amino-acid peptide TKPRPGP. It extends tuftsin, a natural immune-related peptide, with three amino acids. N-acetyl adds a chemical cap at one end; amidation changes the other end. N-acetyl Selank and N-acetyl Selank Amidate therefore name distinct modifications, not interchangeable labels. Animal context Community
“Acetate” and “amidate” mean different things. Acetate describes a salt formulation; amidate refers to the peptide’s end modification. A product called N-acetyl Selank Amidate Acetate can contain both descriptions. Nasal sprays dominate these discussions; SubQ means injection beneath the skin. Reddit r/Nootropics Community

What people hope to feel

Less rumination, social tension and background anxiety. Responders describe a quieter mind rather than a high. Calm focus and steadier emotional reactions are the appeal, but the same family also produces no change, detachment or more anxiety in other reports. Community Personal report Reddit r/Nootropics Reddit r/Nootropics
A more stable form does not guarantee a better experience. One commenter found all Selank analogues alike; another preferred N-acetyl over plain and amidated. The claim that dual capping makes it strongest remains a community hypothesis, not a demonstrated ranking. Reddit r/Nootropics Reddit r/Peptides Reddit r/Nootropics

Doses people discuss

Amounts are reports, not instructions. 1 mg equals 1,000 mcg; per-spray, per-administration and daily totals differ.

Plain nasal discussions: 250–900 mcg/day, split one to three times. The original record also contains 200–300 mcg/day, separate 250–500 mcg administrations once or twice daily, and 300 mcg administrations two or three times daily. Higher discussions reach 600–1,200+ mcg/day; individual logs include 500–600 mcg/day for months or about 1 mg/day short runs. These are not one dose ladder. Community
N-acetyl and amidate sprays: amounts and outcomes differ. One nasal user reported little benefit from N-acetyl 300 mcg, plain 400 mcg and N-acetyl amidate 200 mcg administrations. Another N-acetyl user tried 200 mcg once or twice daily and 400 or 550 mcg once daily with minimal change and uncertain eye strain or twitching. Reddit r/Nootropics Reddit r/Nootropics
Capped-form charts are commercial discussion, not validated equivalents. The original charts list 100–300 mcg per pump, commonly 300 mcg two or three times daily, totaling 600–900 mcg/day. Separate “more potent” claims propose 150–300 mcg/day. A positive N-acetyl account used 250 mcg nasal each morning; a LongeCity stack lists 300 mcg/day without a route. Community Personal report Community guide
SubQ reports need their own amounts. One person describes 175–225 mcg per injection twice daily, totaling 350–450 mcg/day, with unspecified form. Original injection talk includes 150–250 mcg/day, a separate 200–500 mcg/day band, and commercial 0.5 mg charts. None establishes a nasal-to-injection conversion. Reddit r/Peptides Community

Half-life: what is actually known

No dependable human half-life for these nasal variants was established here. One thread asks whether caps extend half-life but supplies no measurement. Original commercial lore separately claims 10–20 minutes in plasma and a 4–6-hour “effective window.” The latter describes presumed effects, not elimination; neither is a verified human N-acetyl amidate half-life. Reddit r/Nootropics Community

Onset: when people notice a change

15–60 minutes nasal is an original reported window; some notice nothing. Other accounts describe immediate calm or a gradual course response. One N-acetyl nasal reporter places onset around two hours. Original SubQ talk says 15–30 minutes, but lacks a reliable form-specific comparison. These are separate impressions, not absorption measurements. Community Reddit r/Peptides Personal report

Duration: how long the experience lasts

Hours of calm and hours of discomfort are different outcomes. Original nasal summaries describe 3–6 hours of calm. One N-acetyl spray report describes about seven hours after a two-hour onset; another describes four hours of detachment. A 200 mcg N-acetyl exposure instead brought two-to-three hours of increased anxiety. Community Personal report Reddit r/Nootropics Personal report
Course effects do not establish single-dose coverage. The record describes changes over days 3–7 and two-to-four-week blocks, including plateau, flatness and nonresponse. Afternoon wear-off motivates some split schedules. Persistent calm or worsening sleep after a course cannot reveal how long intact peptide remained in blood. Community Community Personal report

Cycles and breaks people discuss

Two-to-four-week courses and as-needed use coexist. Original community patterns include 14–21 days, one month on/one month off, two-to-four weeks on with similar time off, and weekdays on/weekends off. A forum commenter proposes no more than 30 days once or twice yearly; that is their rule of thumb, not a tested interval. Community Reddit r/Peptides
A two-week capped-form course with a week off comes from sample guides. That commercial calendar differs from occasional high-stress-day use or repeat courses around travel/exams. Intermittent long-term reports also exist. Switching forms between cycles and absence of classic benzodiazepine withdrawal do not establish tolerance prevention or safe long-term use. Community Reddit r/Peptides

Good to know

More anxiety or worse sleep can occur despite the calming reputation. An intranasal user estimated 400 mcg/day, briefly 600, without relief and with worsening insomnia. Sleep gradually improved after stopping, but longstanding anxiety, sleep problems and later sleep medicines complicate causality. Personal report
Irritation and unwanted dulling also appear. Original reports include nasal burning, dryness, sneezing, runny nose or throat drip; headache, head pressure, dizziness, fatigue and emotional flatness. Less frequent notes describe irritability, vivid dreams, nausea, hot/cold sensations or heart-rate awareness. Injection-site redness is separate. Their frequency and causes are uncertain. Community Reddit r/Nootropics
Product identity and immune reactions remain concerns. Incorrect form labels, uncertain delivered amounts, degradation and contamination complicate reports. FDA flags aggregation, peptide impurities and possible immunogenicity for compounded Selank acetate. Its withdrawn nomination does not resolve those concerns. Community Official context
Combination and long-term safety are unresolved. There is no reassuring interaction map for psychiatric medicines, alcohol or peptide stacks. Pregnancy, breastfeeding and immune-condition cautions remain; autoimmune effects are theoretical. “Non-sedating” claims cannot establish driving fitness, medication equivalence or a reason to change prescribed treatment. Community Personal report

What the community experience adds

Feeling nothing does not identify the cause. Three-form nonresponse sits beside an N-acetyl reporter with little baseline anxiety and weak responses to other nootropics. Replies blame products or routes, but those explanations are untested. One positive 600–1,200 mcg/day account omits exact form and route. Reddit r/Nootropics Reddit r/Nootropics Reddit r/Nootropics
The “calm focus” stack makes credit difficult. Semax plus Selank is often two separately dosed products, not a fixed ratio. The original charts include Semax 100–200 mcg plus Selank 250 mcg in the morning, or Semax 200–300 mcg morning and Selank 250–500 mcg evening. They remain commercial examples, not synergy evidence. Community
Other ingredients can change the story. Noopept, caffeine, L-theanine, racetams, magnesium, adaptogens, DSIP and other cognitive peptides recur. The seven-hour calm report includes bedtime DSIP and TRT. LongeCity’s N-acetyl stack includes memantine and phenylpiracetam hydrazide. Original solo-first sequencing spans five-to-seven days, a discussion habit rather than a validated rule. Community Personal report Community guide
“No withdrawal” is disputed personal language. A reviewer denied an opioid-like feel, while a commenter with long-term opioid use described that feel and mild withdrawal after N-acetyl amidate ran out. Another reports a brief distant, weak-body reaction after an accidental amount, with units/form incomplete. These accounts prove neither an opioid mechanism nor freedom from dependence. Reddit r/Nootropics Reddit r/Nootropics

What the laboratory work can explain

Parent-peptide biology does not measure a capped form’s human effect. Rat work found GABA-related gene-expression changes after nasal Selank; GABA helps regulate nerve activity. A tracer-study abstract identifies degradation fragments but supplies no numerical human half-life. Biological activity after exposure is a different question from clearance or felt calm. Animal context Animal context