Peptide

Semax family variants

Also known as

Semax analogues · Semax analogs · Met-Semax discussion · N-Acetyl Semax family · NA-Semax / NASA family · N-Acetyl Semax Amidate family · ACTH(4-10) Semax-related peptides · MEHFPGP variants · Adamax (Semax-family discussion) · Semax Amidate · Ac-MEHFPGP / Ac-MEHFPGP-NH2

Community talk. May contain inaccuracies. Not medical advice. Not a protocol. Not for human or animal use.

What it is

Different family members	Plain Semax is an ACTH-related peptide. N-acetyl Semax has one end capped; N-acetyl Semax amidate, or NASA, has both capped. Semax amidate has only the C-end cap; Adamax is a separate analogue.
Forms and claims	Nasal sprays and drops dominate, with minority SubQ reports. Longer-lasting or stronger-per-microgram claims do not establish human potency ratios between variants.

Notes

One family, different molecules. Plain Semax is a synthetic ACTH-related peptide: a short chain of seven amino acids. N-acetyl Semax adds a cap at one end; N-acetyl Semax amidate (NASA) adds caps at both ends. Semax amidate is the C-end-only form. Adamax is a separate adamantane-related analogue, not another name for NASA. FDA briefing review of Semax free base and Semax acetate (Official context · Accessed 2026-09-30)

The stability story is a claim about the modification. Communities describe caps as protection from peptide-breaking enzymes and expect stronger or longer effects. That does not establish a human potency ratio. “Met-Semax” usually means the parent; acetate salt and N-acetyl modification are different things. Semax dosage (Community discussion · Accessed 2026-09-30) · FDA briefing review of Semax free base and Semax acetate (Official context · Accessed 2026-09-30)

Nasal products dominate this discussion. Drops and sprays are discussed alongside minority subcutaneous (SubQ) reports. Percentage strength, micrograms per pump and total vial mass describe different quantities; they cannot identify the same exposure.

Source context — FDA briefing review of Semax free base and Semax acetate: Regulatory evidence review of parent free base/acetate, not a capped-variant human PK trial. Cited original rat papers were not independently read. No quantitative half-life supplied by this review.

Source context — Semax dosage: Bliptane's formulation shifts between N-acetyl amidate, Adamax and plain-product discussion; not a verified single-variant regimen. Enzyme and BBB claims are secondhand. Do not convert chart preferences into recommendations.

What people notice

Focus and stamina	Some describe clearer studying, programming, recall or verbal fluency. Others feel wired, unchanged, foggy or less able to work; no modified form consistently wins.
Mood differs from productivity	One Adamax user described better mood and sleep after three days, with little task-initiation benefit. Another reported clearer learning after a week alongside headaches and poor sleep.
A specific adverse course	One NASA spray author reported word confusion, losing their place, forgetfulness and time blindness during burnout recovery while also taking atomoxetine 100 mg.

Notes

Focus, recall and stamina for demanding work. Accounts describe less mental drift, smoother studying, easier programming and better verbal fluency. Some feel subtly clearer rather than driven; others feel wired, unchanged or less able to work. Modified forms do not have a consistent winner. Any experiences with Selank/Semax analogues? (Community discussion · Accessed 2026-09-30) · Strange affects from amidate? (Personal report · Accessed 2026-09-30)

Mood improvement can differ from useful focus. One Adamax author reported better mood and sleep after three days but little improvement in task initiation. Another described clearer learning after a week alongside headaches and difficulty sleeping. 3 days on Adamax, my experience (Personal report · Accessed 2026-09-30) · My Adamax and Selank Experience (Personal report · Accessed 2026-09-30)

Feeling focused can still mean getting less done. An amidate switcher taking ADHD medication described spacing out and doom scrolling despite perceived attention. Separately, the 285 mcg-pump author reported word confusion, losing their reading place, forgetfulness and time blindness during burnout recovery with atomoxetine 100 mg. Strange affects from amidate? (Personal report · Accessed 2026-09-30) · Brain fog from NA Semax Amidate (Personal report · Accessed 2026-09-30)

Source context — Any experiences with Selank/Semax analogues?: Specific analogues, routes and delivered doses are often unstated. Different commenters remain separate; colloquial cannabis comparisons do not establish pharmacology.

Source context — Strange affects from amidate?: Prescription co-use, no delivered dose, no verified identity or controlled comparison. Reply mistakenly pivots to Adamax and cannot establish the OP's pharmacology.

Source context — 3 days on Adamax, my experience: Short unblinded report, ambiguous exact formulation, no objective percentage measurement. LLM prediction of a day-14 peak is not evidence. Planned modafinil addition is not an observed result.

Source context — My Adamax and Selank Experience: One self-report also cross-posted in r/BodyHackGuide; counts as one account. Unverified 500 mcg/day intranasal Adamax and 600 mcg/day Selank. Other compounds, fasting and expectations confound changes.

Source context — Brain fog from NA Semax Amidate: Burnout recovery and atomoxetine co-exposure confound attribution. Label claimed 285 mcg per pump; product identity and causality unverified. Relative timestamps were not converted into dates.

Doses people talk about

Plain nasal chart bands	100–300 mcg per use, 1–2 times daily, and separate 250–600 mcg per-use, 1–3-times-daily charts circulate. Broader per-use and daily totals are different claims, without a verified universal band.
Single-cap and NASA nasal	Single-cap charts describe 100–300 mcg per use. NASA charts repeat 200–400 mcg once or twice daily, with broader 100–600 mcg per-use or 0.2–1.2 mg daily figures. These are not validated conversion rules.
NASA pump accounts	A null course used two labeled 100 mcg pumps each day on days one and two, then four total on day three. The fog account used two labeled 285 mcg pumps daily for two days, then one on day three.
Adamax and SubQ differ	One nasal Adamax user reported 500 mcg/day. A separate SubQ NASA user described 1 mg morning, later 1 mg plus 0.5 mg afternoon, then 1 mg twice daily. Neither supplies a nasal-to-injection conversion.

Notes

Plain nasal: chart bands overlap. Existing charts describe 100–300 mcg per use, 1–2 times daily; 250–600 mcg per use, 1–3 times daily; and broader 250–1,000 mcg per-use or 300–1,500+ mcg daily totals. These are different chart claims, not one verified range.

Single-cap and NASA nasal: keep the label explicit. Single-cap charts discuss 100–300 mcg per use and fewer administrations. NASA charts repeat 200–400 mcg once or twice daily, with broader 100–600 mcg per-use and 0.2–1.2 mg daily figures. Other pump charts quote 600–900 mcg daily. Claimed 30–40% dose reductions or NASA at 60–70% of parent mass are unvalidated equivalence rules.

Individual sprays are more concrete than a universal band. Tek-War used labeled 100 mcg pumps: two total on day one, two on day two, four on day three, without benefit. The brain-fog author used two labeled 285 mcg pumps daily for two days, then one on day three. N-Acetyl-Semax-Amidate Acetate, a bit of a let down (Personal report · Accessed 2026-09-30) · Brain fog from NA Semax Amidate (Personal report · Accessed 2026-09-30)

Adamax and SubQ reports remain separate. Adamax charts list 100–300 mcg per use; one inspected nasal author reported 500 mcg daily. Existing SubQ tables cite Adamax up to 500–1,000 mcg daily and NASA starting around 500 mcg daily, rising toward 1,000 mcg once or twice daily. One LongeCity NASA author reported 1 mg morning, then 1 mg plus 0.5 mg afternoon, then 1 mg twice. None establishes a nasal-to-injection conversion. My Adamax and Selank Experience (Personal report · Accessed 2026-09-30) · Semax experiences? — page 2 (Personal report · Accessed 2026-09-30)

Source context — N-Acetyl-Semax-Amidate Acetate, a bit of a let down: Unverified 100 mcg spray and three-day unblinded course. Brief headache with coffee on day two. Other commenters' dose advice is not adopted; lack of effect is not proof of a bad product.

Source context — Semax experiences? — page 2: Old unblinded account, unverified product and no objective testing. One author, not a population dose band; route does not transfer to nasal use.

Half-life, onset & duration

Felt onset	Individual nasal reports range from about five minutes for a NASA head sensation, 5–10 minutes for a single-cap-labeled product, and 20–30 minutes or hours for Adamax.
Felt duration	Different analogue users report under an hour or all day. A single-cap-labeled nasal account reports 3–5 hours of wakefulness; one Adamax comparison describes 4–5 hours of productive work. Sleep disruption can last beyond useful focus.
Half-life	No dependable human value for the capped variants or Adamax is established. Parent 2–5-minute, NASA 20–30-minute and unspecified 2–10-hour claims have different, unverified origins.

Notes

Minutes in some nasal accounts; hours in others. One NASA author noticed a head sensation around five minutes, then subtle focus; delivery was uncertain. A single-cap-labeled report describes euphoria at 5–10 minutes. Adamax reports include 20–30 minutes or a few hours. Existing 15–60-minute lore is not a predictable onset. Documenting my first time experience with Semax (Personal report · Accessed 2026-09-30) · different versions of selank/semax (Personal report · Accessed 2026-09-30) · Adamax after three weeks, my take vs regular Semax (Personal report · Accessed 2026-09-30) · My Adamax and Selank Experience (Personal report · Accessed 2026-09-30)

Some courses produce no noticeable onset. The three-day NASA course was null throughout. Adamax learning changes reported after a week describe repeated use, not the onset of one administration. N-Acetyl-Semax-Amidate Acetate, a bit of a let down (Personal report · Accessed 2026-09-30) · My Adamax and Selank Experience (Personal report · Accessed 2026-09-30)

Under an hour and all day appear in the same thread. Two different analogue users reported these opposite stimulation windows. A single-cap-labeled nasal account reports 3–5 hours of wakefulness. Existing parent 2–4-hour, capped 4–8-hour and longer coverage charts are functional-duration lore, not blood measurements. Any experiences with Selank/Semax analogues? (Community discussion · Accessed 2026-09-30) · different versions of selank/semax (Personal report · Accessed 2026-09-30)

Longer coverage can bring sleep costs. An Adamax comparison report describes 4–5 hours of productive work versus about two hours with Semax. Other analogue users report insomnia. Neither a work window nor late-night alertness tells when the peptide has left human plasma. Adamax after three weeks, my take vs regular Semax (Personal report · Accessed 2026-09-30) · Any experiences with Selank/Semax analogues? (Community discussion · Accessed 2026-09-30)

Minutes and hours both circulate, with different origins. Existing secondary lore quotes parent Semax at 2–5 minutes and NASA at 20–30 minutes; a Reddit chart-style reply calls unspecified Semax 2–10 hours. None supplies a measured human clearance study. Parent rapid-breakdown claims draw on animal/laboratory context, not established human kinetics. Does anyone know the correct dosage for Sub-Q N-Acetyl Semax Amidate? (Secondhand community claim · Accessed 2026-09-30)

Longer stability is not a verified human half-life. The single-cap claim of about 30 minutes greater proteolysis resistance concerns experimental media, not human elimination. No dependable human half-life for the capped variants or Adamax was established in this review. Semax dosage (Community discussion · Accessed 2026-09-30)

Source context — Documenting my first time experience with Semax: One unblinded self-report. Depakote ER 500 mg, doxepin 50 mg and propranolol 10 mg were disclosed; next-day uridine, CDP choline, KSM-66 and Longvida were each 300 mg. Product/amount uncertain; no proof of superiority or interaction.

Source context — different versions of selank/semax: One unverified label with no dose or product authentication; oral comparison not substantiated. Stimulating metaphors were not repeated as an effect ranking.

Source context — Adamax after three weeks, my take vs regular Semax: Publication date unavailable; account authenticity and commercial independence unverified. No exact amount; comments/speculative receptor explanations do not establish PK. Use narrowly as a report.

Source context — Does anyone know the correct dosage for Sub-Q N-Acetyl Semax Amidate?: Poster repeats a chart-like number without a human clearance study. Cannot treat the surrounding amidate question as authentication of the reply's product, route or half-life.

Cycles people discuss

Different course charts	5–14-day work blocks and 10–30-day courses circulate. NASA charts describe 30 days at higher totals or 60 days around 600 mcg/day; Adamax charts describe 2–4 or 4–8 weeks. These community or commercial patterns have no validated optimum.
Break rules disagree	10 days on/10 off, a month on/two weeks off and equal time off all appear. Diminishing focus, headaches, irritability and poor sleep prompt pauses; changing variants does not establish a reset.

Notes

Short blocks and longer courses coexist. Existing notes describe 5–14-day work sprints and 10–30-day courses. NASA charts extend to 30 days at higher totals or 60 days around 600 mcg/day; Adamax charts describe 2–4 or 4–8 weeks. These commercial/community patterns have no validated optimum.

Break rules disagree. One nasal poster uses 10 days on/10 days off; a chart-style reply lists a month on/two weeks off. Other notes describe several days to weeks off or equal time off. Diminishing focus, irritability, headaches and poorer sleep are reported reasons to pause; form switching does not establish a reset. Semax dosage (Community discussion · Accessed 2026-09-30) · Does anyone know the correct dosage for Sub-Q N-Acetyl Semax Amidate? (Secondhand community claim · Accessed 2026-09-30)

Stacks

Selank family	Pairing charts describe 300–600 mcg Semax-class with 250–600 mcg Selank-class the same day, or commercial 50:50 blends. One user combined Adamax 500 mcg/day with Selank 600 mcg/day after separate weeks, mainly describing calmer study.
Other nootropics and medicines	Caffeine, L-theanine, racetams, Noopept and prescription drugs accompany different reports. The main NASA first-use account also changed several supplements, so a promising first evening did not isolate or reliably repeat its effect.

Notes

Selank is a companion, not proof of synergy. Existing pairing charts discuss 300–600 mcg Semax-class with 250–600 mcg Selank-class the same day, including commercial 50:50 blends. The inspected Adamax author used 500 mcg and Selank 600 mcg daily in separate weeks, then together; the combination mainly felt calmer during study. Caffeine, racetams, Noopept and prescription drugs further blur credit. My Adamax and Selank Experience (Personal report · Accessed 2026-09-30)

A promising first evening may not repeat. Sam-Wolf-Medium described several hours of subtle NASA focus while taking prescribed Depakote ER 500 mg, doxepin 50 mg and propranolol 10 mg. Next day, four total sprays plus uridine, CDP choline, KSM-66 and Longvida (300 mg each) brought calm, lightheadedness and little repeat NASA effect. Documenting my first time experience with Semax (Personal report · Accessed 2026-09-30)

+ Caffeine / L-theanine: Very common layer; strong coffee + high NASA is a frequent overstimulation path. [community]

Watch for

Nose, mood and sleep	Burning, dryness, bitter drip, headache, dizziness, anxiety, irritability, emotional flatness and insomnia are reported. Feeling focused can still come with worse task completion.
Label and unit errors	0.1% and 1%, mg and mcg, pump output and total vial mass describe different quantities. Mislabeling, degradation and contamination are separate risks.
Analogue evidence gaps	Parent Semax evidence does not certify capped variants. The saved FDA review identifies missing human PK and possible immune or impurity risks; long-term variant risks remain unknown.

Notes

Nasal discomfort and unwanted activation matter. Reports include burning, dryness, bitter drip, headache, dizziness, anxiety, irritability, nausea, vivid dreams and emotional flatness. Morning or early-afternoon use, sometimes ending by 1–3 PM, is a sleep-protection habit in discussion, not a clearance interval. Semax experiences? — page 2 (Personal report · Accessed 2026-09-30)

Labels and stacks complicate attribution. Mistaking 1% for 0.1%, or mg for mcg, changes the stated amount substantially. Spray output, degradation, mislabeling and contamination are separate uncertainties. Hair-loss and visual-change anecdotes remain unconfirmed; medication co-use does not establish a specific interaction.

Parent evidence cannot certify an analogue. FDA identifies missing human PK and potential immune/impurity risks for parent Semax preparations. Its rat distribution and tissue-breakdown findings do not provide human capped-variant kinetics. Unknown long-term risks remain. FDA briefing review of Semax free base and Semax acetate (Official context · Accessed 2026-09-30)

Source context — Semax experiences? — page 2: Old unblinded account, unverified product and no objective testing. One author, not a population dose band; route does not transfer to nasal use.

Full notes

Semax family variants are related peptides discussed for focus, memory and mental stamina. People compare plain Semax with capped forms and Adamax for intensity and staying power, but reports range from subtle clarity to no benefit, brain fog or poor sleep. The variants are not interchangeable.

What changes between the variants

One family, different molecules. Plain Semax is a synthetic ACTH-related peptide: a short chain of seven amino acids. N-acetyl Semax adds a cap at one end; N-acetyl Semax amidate (NASA) adds caps at both ends. Semax amidate is the C-end-only form. Adamax is a separate adamantane-related analogue, not another name for NASA. Community Official context
The stability story is a claim about the modification. Communities describe caps as protection from peptide-breaking enzymes and expect stronger or longer effects. That does not establish a human potency ratio. “Met-Semax” usually means the parent; acetate salt and N-acetyl modification are different things. Community Reddit · r/Biohacking Official context
Nasal products dominate this discussion. Drops and sprays are discussed alongside minority subcutaneous (SubQ) reports. Percentage strength, micrograms per pump and total vial mass describe different quantities; they cannot identify the same exposure. Community Community

What people hope to get

Focus, recall and stamina for demanding work. Accounts describe less mental drift, smoother studying, easier programming and better verbal fluency. Some feel subtly clearer rather than driven; others feel wired, unchanged or less able to work. Modified forms do not have a consistent winner. Community Reddit · r/Nootropics Personal report
Mood improvement can differ from useful focus. One Adamax author reported better mood and sleep after three days but little improvement in task initiation. Another described clearer learning after a week alongside headaches and difficulty sleeping. Personal report Personal report

Doses discussed by form

Plain nasal: chart bands overlap. Existing charts describe 100–300 mcg per use, 1–2 times daily; 250–600 mcg per use, 1–3 times daily; and broader 250–1,000 mcg per-use or 300–1,500+ mcg daily totals. These are different chart claims, not one verified range. Community
Single-cap and NASA nasal: keep the label explicit. Single-cap charts discuss 100–300 mcg per use and fewer administrations. NASA charts repeat 200–400 mcg once or twice daily, with broader 100–600 mcg per-use and 0.2–1.2 mg daily figures. Other pump charts quote 600–900 mcg daily. Claimed 30–40% dose reductions or NASA at 60–70% of parent mass are unvalidated equivalence rules. Community
Individual sprays are more concrete than a universal band. Tek-War used labeled 100 mcg pumps: two total on day one, two on day two, four on day three, without benefit. The brain-fog author used two labeled 285 mcg pumps daily for two days, then one on day three. Personal report Personal report
Adamax and SubQ reports remain separate. Adamax charts list 100–300 mcg per use; one inspected nasal author reported 500 mcg daily. Existing SubQ tables cite Adamax up to 500–1,000 mcg daily and NASA starting around 500 mcg daily, rising toward 1,000 mcg once or twice daily. One LongeCity NASA author reported 1 mg morning, then 1 mg plus 0.5 mg afternoon, then 1 mg twice. None establishes a nasal-to-injection conversion. Community Personal report Personal report

Half-life: the numbers being circulated

Minutes and hours both circulate, with different origins. Existing secondary lore quotes parent Semax at 2–5 minutes and NASA at 20–30 minutes; a Reddit chart-style reply calls unspecified Semax 2–10 hours. None supplies a measured human clearance study. Parent rapid-breakdown claims draw on animal/laboratory context, not established human kinetics. Community Reddit · r/Peptides
Longer stability is not a verified human half-life. The single-cap claim of about 30 minutes greater proteolysis resistance concerns experimental media, not human elimination. No dependable human half-life for the capped variants or Adamax was established in this review. Community Reddit · r/Biohacking

Onset: first sensations versus useful changes

Minutes in some nasal accounts; hours in others. One NASA author noticed a head sensation around five minutes, then subtle focus; delivery was uncertain. A single-cap-labeled report describes euphoria at 5–10 minutes. Adamax reports include 20–30 minutes or a few hours. Existing 15–60-minute lore is not a predictable onset. Personal report Personal report Personal report Personal report
Some courses produce no noticeable onset. The three-day NASA course was null throughout. Adamax learning changes reported after a week describe repeated use, not the onset of one administration. Personal report Personal report

Duration: how long people feel a change

Under an hour and all day appear in the same thread. Two different analogue users reported these opposite stimulation windows. A single-cap-labeled nasal account reports 3–5 hours of wakefulness. Existing parent 2–4-hour, capped 4–8-hour and longer coverage charts are functional-duration lore, not blood measurements. Reddit · r/Nootropics Personal report Community
Longer coverage can bring sleep costs. An Adamax comparison report describes 4–5 hours of productive work versus about two hours with Semax. Other analogue users report insomnia. Neither a work window nor late-night alertness tells when the peptide has left human plasma. Personal report Reddit · r/Nootropics

Cycles and breaks

Short blocks and longer courses coexist. Existing notes describe 5–14-day work sprints and 10–30-day courses. NASA charts extend to 30 days at higher totals or 60 days around 600 mcg/day; Adamax charts describe 2–4 or 4–8 weeks. These commercial/community patterns have no validated optimum. Community
Break rules disagree. One nasal poster uses 10 days on/10 days off; a chart-style reply lists a month on/two weeks off. Other notes describe several days to weeks off or equal time off. Diminishing focus, irritability, headaches and poorer sleep are reported reasons to pause; form switching does not establish a reset. Reddit · r/Biohacking Reddit · r/Peptides Community

Good to know

Nasal discomfort and unwanted activation matter. Reports include burning, dryness, bitter drip, headache, dizziness, anxiety, irritability, nausea, vivid dreams and emotional flatness. Morning or early-afternoon use, sometimes ending by 1–3 PM, is a sleep-protection habit in discussion, not a clearance interval. Community Community Personal report
Labels and stacks complicate attribution. Mistaking 1% for 0.1%, or mg for mcg, changes the stated amount substantially. Spray output, degradation, mislabeling and contamination are separate uncertainties. Hair-loss and visual-change anecdotes remain unconfirmed; medication co-use does not establish a specific interaction. Community
Parent evidence cannot certify an analogue. FDA identifies missing human PK and potential immune/impurity risks for parent Semax preparations. Its rat distribution and tissue-breakdown findings do not provide human capped-variant kinetics. Unknown long-term risks remain. Official context

What the accounts reveal

A promising first evening may not repeat. Sam-Wolf-Medium described several hours of subtle NASA focus while taking prescribed Depakote ER 500 mg, doxepin 50 mg and propranolol 10 mg. Next day, four total sprays plus uridine, CDP choline, KSM-66 and Longvida (300 mg each) brought calm, lightheadedness and little repeat NASA effect. Personal report
Feeling focused can still mean getting less done. An amidate switcher taking ADHD medication described spacing out and doom scrolling despite perceived attention. Separately, the 285 mcg-pump author reported word confusion, losing their reading place, forgetfulness and time blindness during burnout recovery with atomoxetine 100 mg. Personal report Personal report
Selank is a companion, not proof of synergy. Existing pairing charts discuss 300–600 mcg Semax-class with 250–600 mcg Selank-class the same day, including commercial 50:50 blends. The inspected Adamax author used 500 mcg and Selank 600 mcg daily in separate weeks, then together; the combination mainly felt calmer during study. Caffeine, racetams, Noopept and prescription drugs further blur credit. Community Personal report
No response does not settle identity or mechanism. Tek-War's three-day null course sits beside positive and adverse accounts. Replies speculate about amount, preparation or subtle effects, but do not prove those explanations. A product advertised as enhanced is not guaranteed to feel stronger or work better. Personal report Community