STUDresearch · Non-peptide
Tributyrin
Also known as
glyceryl tributyrate · butyrate triglyceride · CoreBiome · tributyrin butyrate
Community talk. May be wrong. Not medical advice. Not a protocol. Not for human or animal use.
Non-peptide
Niche talk
Mixed
Oral capsules or gelcaps
Gut & inflammation peptides
Swallowed for the colon — some still talk whole-body fog and mood when the gut shifts.
What people say
Tributyrin is glycerol esterified with three butyrate chains and is discussed as an oral butyrate-delivery form. It is not BPC-157 or dietary fiber, and downstream butyrate is distinct from intact parent tributyrin.
Doses people talk about
Rows are observations, not a ladder. Product form, meals, prior butyrate tolerance and concurrent gut interventions differ.
How it may feel
One 500 mg-with-food poster reported a sudden clarity/mood lift that ended after about 40 minutes, then anxiety/irritability, insomnia and diarrhea on repeat exposures, and later stopped. Separate success or remission posts involved different histories and large stacks.
Actual adverse-reaction exposure500 mg once with food
One gelcap; the same reporter repeated 500 mg with later meals and described reproducible positive then adverse effects.
SIBO-success account500 mg + 500 mg with meals
An older community SIBO-success account describes 500 mg with one meal and 500 mg with another; this is distinct from the separate three-times-daily remission stack.
Remission-stack account500 mg three times daily oral
Reported with or without food amid numerous other products; remission attribution to tributyrin is not possible.
Lower capsule example~300 mg oral
A separate common product-size example in the old notes.
Half-life & effect duration
- Half-life in the body
- Parent tributyrin · oralNo settled estimate
- Felt duration people report
- One repeated-exposure accountClarity or mood lift for about 40 minutes
- After that liftAnxiety or irritability, then diarrhea; later exposures worsened the reaction
Cycles people discuss
Community use is usually framed as a daily gut experiment rather than a short peptide course. The notes do not establish a necessary cycling pattern, and multi-product remission stacks obscure attribution.
Timing
Some accounts pair capsules with meals; a separate remission-stack account allowed with or without food. Product copy favors morning use. Prior sodium-butyrate reactions appear in tolerance discussions, not as a starting-dose rule.
Stacks
Tributyrin appears with probiotics, diet changes, zinc L-carnosine, BPC-157, KPV, PEA and other gut products. The 500 mg three-times-daily remission post contained a large stack, so remission cannot be assigned to tributyrin.
Watch for
Anxiety / irritability / insomnia: Same r/Microbiome first-week log.
Tap a line to jump into the full notes. Research only — may be wrong.
Timing context & sources
Half-life in the body
A consumer oral parent-tributyrin half-life was not established in the reviewed evidence.
A small advanced-cancer study used 150–200 mg/kg three times daily and sampled downstream butyrate for four hours; brief butyrate exposure is not a clean parent-tributyrin estimate for 300–500 mg gelcaps.
Different endpoint, very high oncology dosing, small ill population and no directly usable parent concentration-time estimate.
- Oral tributyrin in patients with advanced solid tumors (opens in a new tab)Abstract and study details read: 20 advanced-solid-tumor patients, 150 or 200 mg/kg orally three times daily, pharmacokinetic sampling through four hours; brief systemic butyrate exposure motivated the schedule.Small oncology dose-escalation study at very high weight-based doses; downstream butyrate, not a clean consumer parent-tributyrin half-life.
Felt duration people report
About 40 minutes of transient clarity/mood change in one repeated-exposure account.
The same reporter described a sudden clarity/mood lift that ended after about 40 minutes, followed by anxiety/irritability and then diarrhea; later doses reproduced and worsened adverse effects.
One unblinded consumer-product account; reported duration is not onset, parent PK or evidence of benefit.
- Very odd reaction to tributyrin (opens in a new tab)OP and same-author replies read: 500 mg gelcap with food, sudden clarity/mood change that ended after about 40 minutes, then anxiety/irritability; liquid stool next day; repeat lunch/dinner exposures with worse anxiety, insomnia and diarrhea; later stopped because of sick/irritable feeling.One uncontrolled account with an unverified product; no objective exposure measure or later outcome update.
Other context in this card
- My current remission/general health stack (opens in a new tab)Full post read: tributyrin 500 mg three times daily, with or without food, listed among a large stack including PEA, colostrum and berberine-related interventions.Large uncontrolled stack; cannot attribute remission, safety or timing to tributyrin.
What people say
- SIBO-adjacent n=1: r/SiboSuccessStories — tolerated perfectly after other butyrates failed; more BMs in days; inflammation “devastating → manageable.” Not a cure, still careful. anecdote
- Head-clear / mood flicker: r/Microbiome first-dose 500 mg with food: sudden fog drop and mood up, then liquid stool and next-day anxiety/insomnia. Split reviews. anecdote
- Butyrate delivery pitch: Tributyrin as a way to feed colonocytes when your own producers are low. forum
- What it doesn’t prove: Erasing methane/H2S SIBO, or a personality transplant. The success poster said that out loud. anecdote
- In-vitro / formulation: CoreBiome-class tributyrin vs free butyrate on barrier/immune readouts in lab systems. lab
Doses people talk about
- Ingredient starting copy: ~300 mg active tributyrin, often first thing in the morning. forum
- Forum 500 mg: First gel-cap with food is a common n=1. anecdote
- Actual community regimens: An older SIBO-success note describes 500 mg with one meal plus 500 mg with another. A separate remission-stack poster listed 500 mg three times daily, with or without food, among many other products. anecdote
- Consumer bottles: 150–550 mg tributyrin per serving depending on brand math (some list “active” vs fill). forum
- Don’t copy sodium-butyrate gram doses onto tributyrin caps. forum
- Framing: Supplement milligrams of tributyrin — not a prescription. forum
How it may feel
- One 500 mg-with-food account: After the first gelcap, the poster described a sudden but brief reduction in brain fog and a mood lift while digesting food; the effect ended after about 40 minutes and anxiety/irritability followed. Liquid stool followed the next day. Repeated lunch/dinner exposures reproduced the pattern with worse anxiety, insomnia and diarrhea. anecdote
- Days 2–7: SIBO poster’s BM-frequency window; also the liquid-stool window. forum
- Dose-up: One log doubled 500 mg to 500+500 with meals and planned another biome test. anecdote
- Stop outcome in the same report: The 500 mg poster later said they stopped because it made them feel sick and irritable; no later resolution update was visible in the thread. anecdote
- Weeks 2–3: The short supp-study length. trial
Around the dose
- Prior intolerance context: A legacy community note compares tributyrin tolerance with prior sodium-butyrate reactions; it is not a starting-dose instruction. forum
- Biome tests are how some people decide to double. n=1 labs. anecdote
- Not a skip-the-SIBO-workup move. forum
Cycles people discuss
- Daily while the gut experiment is on — not a 10-day Khavinson course. forum
- Reassess in weeks, not years. forum
- Consistency > complexity is the ingredient-maker line. forum
Timing
- With meals in the logs that didn’t immediately dump. forum
- Morning habit in CoreBiome-style copy. forum
- Colon delivery is the point, not a plasma peak you feel like caffeine. forum
- Human PK boundary: A small advanced-cancer study sampled butyrate after very high oral tributyrin doses and described brief systemic butyrate exposure that motivated three-times-daily administration. It does not establish a clean parent-tributyrin half-life for consumer 300–500 mg gelcaps; the commonly repeated 40-minute number should not be presented here as measured human parent PK. trial
More on what it is
- What it is: Three butyrate chains on glycerol. A butyrate prodrug that is supposed to survive farther than sodium butyrate salt. Not BPC. Not a fiber. forum
- Why people search it: r/SIBO and r/Microbiome when sodium butyrate wrecked them. One success-story post called tributyrin the form they could finally tolerate. anecdote
- Vs sodium butyrate: Same destination molecule, different GI fight. People who dump-liquid on salt sometimes keep the triglyceride. forum
- Not: Not a probiotic, not rifaximin, not a peptide. forum
- CoreBiome: Patented tributyrin ingredient in a lot of “better butyrate” bottles — industry name, not a shop SKU. Formulation papers talk colon delivery vs free butyrate. lab
- 2025 supp study: Three weeks daily tributyrin raised butyrate and shifted some species in a small human-adjacent gut model / clinical supp paper. Not a SIBO cure trial. trial
Stacks
- Zinc L-carnosine / BPC / KPV: Gut-lining neighbors. forum
- Probiotics / low-FODMAP: Always in the same posts. forum
- Don’t stack three butyrate forms and then blame tributyrin for the toilet. forum
Storage notes
- Capsules: Dry bottle. Not a peptide pin. forum
- No mix instructions here: STUDresearch does not list reconstitution charts. forum
Watch for
- Liquid stool: First-week classic. anecdote
- Anxiety / irritability / insomnia: Same r/Microbiome first-week log. anecdote
- Herx-vs-too-much-butyrate argument: Unsettled. forum
- Candida-feeding worry: Posted, not proven. forum
- Not a SIBO monotherapy. forum
- Alarm GI: Blood, fever, obstruction — clinic. forum
- Research-only framing for this map: Discussion of community practice — not a recommendation to use. forum
Evidence mix
Mostly community / anecdote tags
Full: every bullet (trial + community). Use Scan for a faster bro-science read.