Non-peptide

GW0742

Also known as

GW-0742 · GW 0742 · GW610742 · GW-610742 · Fitorine · Lipoline (forum trade nicknames) · Super Cardarine (community nickname) · Advanced Cardio (vendor branding)

Community talk. May contain inaccuracies. Not medical advice. Not a protocol. Not for human or animal use.

What it is

Identity	An experimental metabolic compound activating PPAR-delta/beta, a receptor involved in fuel use. It is related to Cardarine and is discussed for cardio and leanness.
Super Cardarine claims	It is not an androgen or SARM. Stronger-per-milligram branding does not establish better human results or a safer alternative to Cardarine.

Notes

A metabolic research compound related to Cardarine. GW0742 activates PPAR-delta/beta, a receptor involved in regulating fuel metabolism. People call it Super Cardarine or Cardarine 2.0. It is not an androgen or SARM; stronger-per-milligram branding does not establish better human results. Perez Diaz et al. — In silico modelling of prostacyclin and other lipid mediators to nuclear receptors (Animal context · Accessed 2026-09-30) · GW-0742 vs GW-501516 (Cardarine) (Secondhand community claim · Accessed 2026-09-30)

GW0742 is an experimental metabolic compound people compare with Cardarine for easier cardio and leanness. Reports range from longer rides to no endurance improvement or unpleasant heart-rate and fatigue symptoms. Claims of a stronger or safer alternative remain unproven.

Source context — Perez Diaz et al. — In silico modelling of prostacyclin and other lipid mediators to nuclear receptors: Abstract only; not a GW0742 human pharmacokinetic study. Used to resolve the community citation error, not to supply a quick-subject value.

Source context — GW-0742 vs GW-501516 (Cardarine): Half-life is explicitly a bet, not measured kinetics; linked abstract's short half-life refers to prostacyclin. Some replies give prescriptive stacking advice, excluded.

What people notice

Easier cardio for some	A cyclist described less breathlessness and longer rides; another user reported lower exercise heart rate. Other endurance users noticed little improvement.
Weight and endurance differ	Some describe weight loss without easier cardio; another reported more visible veins while gaining weight. Changing diet, training and other drugs prevent a clean GW0742 comparison.

Notes

Easier cardio, longer sessions and recovery. A cycling poster described less breathlessness and longer rides. A forum user described lower exercise heart rate; other endurance users noticed little change. These are personal impressions, not controlled performance comparisons. GW0742 weight loss and endurance update (Personal report · Accessed 2026-09-30) · Who has tried GW0742 (Community discussion · Accessed 2026-09-30) · SLU-PP-332 vs GW1516/0742 Endurance (Personal report · Accessed 2026-09-30)

Leanness or weight change can differ from endurance. Some report weight loss without easier cardio; another described more visible veins while body weight increased. Diet, training and other compounds complicate the fat-loss story. Gw0742 — your experiences (Community discussion · Accessed 2026-09-30) · Starting ReceptorChem GW0742 (Community discussion · Accessed 2026-09-30) · GW0742 weight loss and endurance update (Personal report · Accessed 2026-09-30)

Source context — GW0742 weight loss and endurance update: One uncontrolled account, changing training/diet and schedule, no power/heart-rate protocol or verified identity. Pill preference does not verify original dosage form or superiority.

Source context — Who has tried GW0742: Plan is not a completed exposure; route not supplied. Forum has seller advertising and affiliated participants; #8 has no objective testing. Replies about Cardarine alone are excluded.

Source context — SLU-PP-332 vs GW1516/0742 Endurance: No GW amounts, route or duration supplied. Other replies concern SLU, Cardarine or other drugs and are not GW0742 measurements.

Source context — Gw0742 — your experiences: 20 mg comment does not explicitly specify daily frequency or one oral route; no testing proves alleged bunk product. OP's plan is not an outcome.

Source context — Starting ReceptorChem GW0742: Product bottle image not inspected; route not explicitly stated in the textual follow-up. Visual physique judgments are not measured fat loss. Forum claims about absorption/shorter half-life not validated.

Doses people talk about

Oral chart claims	10–25 mg/day and competing 4–10 mg/day bands circulate. These borrow Cardarine culture and potency marketing, without validated human limits.
Daily versus twice weekly	One runner stopped 10 mg daily after three symptomatic days, then later described 4 mg on Monday and Thursday: 8 mg/week, not 4 mg/day. These are stages of the same person's account.
Different split totals	The cyclist later reported 10 mg morning plus 10 mg evening, totaling 20 mg/day. Another used 5 mg morning plus 5 mg bedtime, totaling 10 mg/day, with route unstated.
Injected combination	One account describes slightly over 15 mg GW0742 plus 15 mg SR9011 in one daily injection for about eight weeks. This does not establish an oral equivalent or either component's effect.

Notes

Oral chart talk: 10–25 mg/day; competing 4–10 mg/day claims. These original chart bands reflect Cardarine borrowing and potency marketing. Vendor lines include 20–25 mg/day at the upper end, a claimed 25 mg ceiling, and male/female charts of 10/5 mg/day; none is a validated limit.

10 mg daily caused an early stop; 4 mg twice weekly came later. One runner stopped after three symptomatic days, then later described 4 mg per administration on Monday and Thursday: 8 mg/week, not 4 mg/day. These are different stages of the same person's account. The original 'conservative start' label is unsupported. GW-0742 In Depth Review (Personal report · Accessed 2026-09-30)

Daily and split amounts are different schedules. The cyclist's later 10 mg morning plus 10 mg evening totals 20 mg/day. Another account used 5 mg morning plus 5 mg bedtime: 10 mg/day, route unstated. A null report at 20 mg left frequency and individual routes unclear. GW0742 weight loss and endurance update (Personal report · Accessed 2026-09-30) · Starting ReceptorChem GW0742 (Community discussion · Accessed 2026-09-30) · Gw0742 — your experiences (Community discussion · Accessed 2026-09-30)

An injected combination had two components. One account described slightly over 15 mg GW0742 plus 15 mg SR9011 in one daily injection for about eight weeks. It cannot establish an oral equivalent or the contribution of either compound. SR9011 and GW0742 (Personal report · Accessed 2026-09-30)

Source context — GW-0742 In Depth Review: Unverified products, self-estimated outcomes, home scale, changing schedules and polypharmacy. Author's mechanism, escalation instructions and hydration/safety assurances are not accepted.

Source context — Gw0742 — your experiences: 20 mg comment does not explicitly specify daily frequency or one oral route; no testing proves alleged bunk product. OP's plan is not an outcome.

Source context — SR9011 and GW0742: Injection site, product identity and actual strength not verified; two compounds and historical comparison. Do not count this same commenter elsewhere as an independent user.

Half-life, onset & duration

Felt onset	A few days in one cycling account. Another user had minimal early endurance change and symptoms by day three; pre-workout timing does not measure onset.
Felt duration	One intermittent-use account claims 2–3 days of felt effects with 4 mg Monday/Thursday use. Other users found no endurance benefit, so there is no consistent window.
Half-life	A measured human value is not established here. The 24-hour chart claim and 6–12-hour forum guess lack matching evidence; the latter linked a statement about prostacyclin.

Notes

A few days in one positive cycling account. The cyclist estimated a few days. The runner noticed minimal early endurance change, then symptoms on day three; these do not establish a dependable onset. GW0742 weight loss and endurance update (Personal report · Accessed 2026-09-30) · GW-0742 In Depth Review (Personal report · Accessed 2026-09-30)

One hour pre-workout was a routine, not measured onset. The cyclist described 10 mg/day for 30 days at that timing. Original notes also retain food-assisted absorption claims without confirmation. GW0742 weight loss and endurance update (Personal report · Accessed 2026-09-30)

Two to three days in one intermittent-use story. The runner attached this felt window to 4 mg Monday/Thursday use. It is subjective persistence, not measured clearance. GW-0742 In Depth Review (Personal report · Accessed 2026-09-30)

No consistent benefit window across users. Some describe easier sessions, others no endurance response at all. Original notes retain checking progress around weeks three to four, but this is a community reassessment point, not evidence of predictable duration. Gw0742 — your experiences (Community discussion · Accessed 2026-09-30) · SLU-PP-332 vs GW1516/0742 Endurance (Personal report · Accessed 2026-09-30)

About 24 hours in chart lore; 6–12 hours in a forum guess. The original record retains a claimed 24-hour half-life. An April 2021 commenter instead guessed 6–12 hours, citing a paper whose short-half-life statement actually describes prostacyclin. Neither provides measured human GW0742 clearance. GW-0742 vs GW-501516 (Cardarine) (Secondhand community claim · Accessed 2026-09-30)

Source context — Gw0742 — your experiences: 20 mg comment does not explicitly specify daily frequency or one oral route; no testing proves alleged bunk product. OP's plan is not an outcome.

Source context — SLU-PP-332 vs GW1516/0742 Endurance: No GW amounts, route or duration supplied. Other replies concern SLU, Cardarine or other drugs and are not GW0742 measurements.

Cycles people discuss

Borrowed chart blocks	Eight weeks and 8–12 weeks are Cardarine-derived conventions. Shorter 2–4-week comparisons, 4–6-week blocks and equal time off also appear, without an established safe cycle or recovery interval.
Actual courses vary	Accounts span a three-day adverse stop, two positive weeks and 30 days. An eight-week injected GW0742/SR9011 account concerns a separate combination.

Notes

Eight weeks and 8–12 weeks are borrowed conventions. Original oral charts also mention 2–4-week comparisons, 4–6-week preference blocks, and 8–10-week self-limits around 10 mg/day. A forum poster planned 6–8 weeks; a plan is not a completed successful cycle. Who has tried GW0742 (Community discussion · Accessed 2026-09-30)

Short stops, month-long use and extended use coexist. Accounts span a three-day adverse stop, two positive weeks and 30 days. Original risk threads discuss equal time off, such as 8 on/8 off, and controversial continuous months. None establishes safe use or recovery. GW-0742 In Depth Review (Personal report · Accessed 2026-09-30) · GW0742 weight loss and endurance update (Personal report · Accessed 2026-09-30)

Stacks

MK-677 reports conflict	The runner reported faster easy runs after adding 7.5 mg nightly. A different reply felt worse after adding 12.5 mg. Neither establishes a way to prevent fatigue.
Other combinations	SR9009, Ostarine, S4/S23, RAD-140 and testosterone/AAS appear in different routines; creatine and L-carnitine also occur. The injected SR9011 pair is a separate account, without proven added benefit.

Notes

MK-677 did not reliably solve fatigue. After adding 7.5 mg MK-677 nightly, the runner claimed 5–7% faster easy runs. A different reply felt unimproved on GW 4 mg/day and worse after MK 12.5 mg. Carnitine-depletion explanations remain folklore. GW-0742 In Depth Review (Personal report · Accessed 2026-09-30)

Blend labels hide separate contributions. An original vendor example lists MK-2866 20 mg, SR9009 20 mg and GW0742 20 mg per capsule. A separate log lists S4 about 50 mg/day, S23 about 20 mg/day and GW0742 about 10 mg/day, sometimes with testosterone. These are different combinations, not equivalent dose bands.

Other stack and bloodwork claims stay qualified. Original discussion includes RAD-140, testosterone/AAS, creatine and L-carnitine alongside GW, plus claims of better lipids, triglycerides or fasting glucose. Multi-agent cuts, calories, sleep and conditioning obscure single-compound credit. '200× stronger' remains marketing, not a verified human comparison.

+ SR9009 (Stenabolic): Classic endurance/fat-ox research-chem pairing; oral SR9009 bioavailability is itself heavily debated (injectable SR talk in some advanced threads). [community]

+ Creatine (HCL or mono): Non-PED pairing frequently praised for training output alongside Cardarine/“Super Cardarine.” [community]

+ L-carnitine: Mentioned when carnitine-depletion lore is accepted; evidence quality low. [community]

Watch for

Heart-rate symptoms and fatigue	The runner described racing or irregular heartbeat, headache, nausea, thirst, restlessness and disabling fatigue. These are adverse reports, without evidence they are normal adjustment.
Unresolved long-term risks	Animal heart-growth findings and cancer-related class concerns do not establish human safety or an event rate. Product contents and strength also remain uncertain.
Detection lasts beyond feel	The saved sport rules prohibit PPAR-delta agonists at all times. A controlled oral study detected a GW0742 urine metabolite up to 20 days; that is detection, not felt duration or plasma half-life.

Notes

Racing or irregular heartbeat and disabling fatigue were reported. Headache, nausea, thirst, irritability and restlessness accompanied the runner's heart-rate symptoms. Replies include overwhelming fatigue and feeling worse after adding MK-677; these adverse experiences are not established as a normal adjustment phase. GW-0742 In Depth Review (Personal report · Accessed 2026-09-30)

Heart-growth debate is not settled by feeling good. A 2025 poster argued that animal cardiac findings are protective. The cited research involves animals and different experimental settings; favorable subjective feelings cannot establish human cardiac safety. Cancer-related class concern also remains unresolved for this compound. Why does everyone seem to say GW0742 is bad for your heart? (Secondhand community claim · Accessed 2026-09-30) · Wagner et al. — Vascular-specific PPAR beta/delta overexpression and cardiac hypertrophy (Animal context · Accessed 2026-09-30)

Identity and long-term harms remain uncertain. 'Bunk' accusations do not verify mislabeling. Original reports include strength/contamination worries, GI/skin complaints, extra-carbohydrate 'going hypo' stories and a benign renal-mass anecdote, without proven causation. Pregnancy, adolescence and uncontrolled illness lack usable safety evidence. Gw0742 — your experiences (Community discussion · Accessed 2026-09-30)

Tested sport prohibits this receptor class. WADA's 2026 list prohibits PPAR-delta agonists at all times. Metabolite detection can outlast any felt benefit. WADA 2026 Prohibited List (Official context · Accessed 2026-09-30) · Sobolevsky et al. — Detection of PPARδ agonists GW1516 and GW0742 and their metabolites in human urine (Official context · Accessed 2026-09-30)

Urine detection is a different clock. Sobolevsky's controlled single 15 mg oral study detected GW0742 sulfone up to 20 days, versus 40 days for GW1516. Parent drug was brief and low; GW0742 urinary abundance was roughly tenfold lower. This does not measure plasma half-life or athletic duration. Sobolevsky et al. — Detection of PPARδ agonists GW1516 and GW0742 and their metabolites in human urine (Official context · Accessed 2026-09-30)

Source context — Why does everyone seem to say GW0742 is bad for your heart?: Post quotes animal studies and extrapolates to human protection; reply is subjective with no imaging. Neither is a human safety measurement.

Source context — Wagner et al. — Vascular-specific PPAR beta/delta overexpression and cardiac hypertrophy: 2016 primary experiment uses genetic overexpression, not a human oral GW0742 course; introduction discusses prior agonist work. Erratum link present; not reviewed. Human risk incidence cannot be inferred.

Source context — Gw0742 — your experiences: 20 mg comment does not explicitly specify daily frequency or one oral route; no testing proves alleged bunk product. OP's plan is not an outcome.

Source context — WADA 2026 Prohibited List: Class list gives non-exhaustive GW1516/GW501516 examples rather than naming GW0742. Applies to Code-compliant sport, not general legality.

Source context — Sobolevsky et al. — Detection of PPARδ agonists GW1516 and GW0742 and their metabolites in human urine: Publisher abstract inspected; full methods/participant count and plasma kinetics not inspected. PubMed access degraded to footer. Detection endpoints cannot be converted into activity, half-life or individual washout.

Full notes

What GW0742 is

A metabolic research compound related to Cardarine. GW0742 activates PPAR-delta/beta, a receptor involved in regulating fuel metabolism. People call it Super Cardarine or Cardarine 2.0. It is not an androgen or SARM; stronger-per-milligram branding does not establish better human results. Animal context Reddit r/sarmssourcetalk
Mostly oral discussion; products differ. The original record describes liquids, capsules and 10 mg tablets, with fringe gel marketing. Injection stories also exist, but animal injection routes and gray-market preparations are different exposures. Community Personal report

What people hope to feel

Easier cardio, longer sessions and recovery. A cycling poster described less breathlessness and longer rides. A forum user described lower exercise heart rate; other endurance users noticed little change. These are personal impressions, not controlled performance comparisons. Personal report Anabolic Steroid Forums Personal report
Leanness or weight change can differ from endurance. Some report weight loss without easier cardio; another described more visible veins while body weight increased. Diet, training and other compounds complicate the fat-loss story. Reddit r/sarmssourcetalk Reddit r/sarmssourcetalk Personal report

Doses people discuss

Reported amounts and chart claims, not a regimen. Most charts describe oral use; several first-person posts leave their exact form or route unstated.

Oral chart talk: 10–25 mg/day; competing 4–10 mg/day claims. These original chart bands reflect Cardarine borrowing and potency marketing. Vendor lines include 20–25 mg/day at the upper end, a claimed 25 mg ceiling, and male/female charts of 10/5 mg/day; none is a validated limit. Community
10 mg daily caused an early stop; 4 mg twice weekly came later. One runner stopped after three symptomatic days, then later described 4 mg per administration on Monday and Thursday: 8 mg/week, not 4 mg/day. These are different stages of the same person's account. The original 'conservative start' label is unsupported. Personal report
Daily and split amounts are different schedules. The cyclist's later 10 mg morning plus 10 mg evening totals 20 mg/day. Another account used 5 mg morning plus 5 mg bedtime: 10 mg/day, route unstated. A null report at 20 mg left frequency and individual routes unclear. Personal report Reddit r/sarmssourcetalk Reddit r/sarmssourcetalk
An injected combination had two components. One account described slightly over 15 mg GW0742 plus 15 mg SR9011 in one daily injection for about eight weeks. It cannot establish an oral equivalent or the contribution of either compound. Personal report

Half-life claims disagree

About 24 hours in chart lore; 6–12 hours in a forum guess. The original record retains a claimed 24-hour half-life. An April 2021 commenter instead guessed 6–12 hours, citing a paper whose short-half-life statement actually describes prostacyclin. Neither provides measured human GW0742 clearance. Community Reddit r/sarmssourcetalk
Schedules do not resolve the uncertainty. Cardarine schedule-copying, morning/evening splitting and pre-workout preferences coexist. No inspected account measures human plasma clearance. Community Reddit r/sarmssourcetalk

When people notice something

A few days in one positive cycling account. The cyclist estimated a few days. The runner noticed minimal early endurance change, then symptoms on day three; these do not establish a dependable onset. Personal report Personal report
One hour pre-workout was a routine, not measured onset. The cyclist described 10 mg/day for 30 days at that timing. Original notes also retain food-assisted absorption claims without confirmation. Personal report Community

How long effects may feel present

Two to three days in one intermittent-use story. The runner attached this felt window to 4 mg Monday/Thursday use. It is subjective persistence, not measured clearance. Personal report
No consistent benefit window across users. Some describe easier sessions, others no endurance response at all. Original notes retain checking progress around weeks three to four, but this is a community reassessment point, not evidence of predictable duration. Reddit r/sarmssourcetalk Personal report Community

Cycles people discuss

Eight weeks and 8–12 weeks are borrowed conventions. Original oral charts also mention 2–4-week comparisons, 4–6-week preference blocks, and 8–10-week self-limits around 10 mg/day. A forum poster planned 6–8 weeks; a plan is not a completed successful cycle. Community Anabolic Steroid Forums
Short stops, month-long use and extended use coexist. Accounts span a three-day adverse stop, two positive weeks and 30 days. Original risk threads discuss equal time off, such as 8 on/8 off, and controversial continuous months. None establishes safe use or recovery. Personal report Personal report Community
Androgen-stack timelines are different stories. Original accounts put GW into final oral weeks and 4–6 weeks after a blast. GW is not framed as classic androgen PCT, but this does not make it a substitute for managing an androgen stack. Community Community

What to watch for

Racing or irregular heartbeat and disabling fatigue were reported. Headache, nausea, thirst, irritability and restlessness accompanied the runner's heart-rate symptoms. Replies include overwhelming fatigue and feeling worse after adding MK-677; these adverse experiences are not established as a normal adjustment phase. Personal report
Heart-growth debate is not settled by feeling good. A 2025 poster argued that animal cardiac findings are protective. The cited research involves animals and different experimental settings; favorable subjective feelings cannot establish human cardiac safety. Cancer-related class concern also remains unresolved for this compound. Reddit r/cardarine Animal context Community
Identity and long-term harms remain uncertain. 'Bunk' accusations do not verify mislabeling. Original reports include strength/contamination worries, GI/skin complaints, extra-carbohydrate 'going hypo' stories and a benign renal-mass anecdote, without proven causation. Pregnancy, adolescence and uncontrolled illness lack usable safety evidence. Reddit r/sarmssourcetalk Community
Tested sport prohibits this receptor class. WADA's 2026 list prohibits PPAR-delta agonists at all times. Metabolite detection can outlast any felt benefit. Official context Official context

Supporting research context

Urine detection is a different clock. Sobolevsky's controlled single 15 mg oral study detected GW0742 sulfone up to 20 days, versus 40 days for GW1516. Parent drug was brief and low; GW0742 urinary abundance was roughly tenfold lower. This does not measure plasma half-life or athletic duration. Official context

Community experiences and comparisons

Large cycling gains coexist with no-response stories. The cyclist reported 15-to-50-km rides and 11 lb lost in a month, acknowledging diet's contribution. A former professional endurance athlete on MESO reported little change from either GW. Baseline fitness, training, identity and expectations differ; these accounts cannot be averaged. Personal report Personal report
Cardarine comparisons often disappoint. Several Reddit commenters noticed no meaningful superiority. The injected GW0742/SR9011 user also found no clear cardiovascular advantage over Cardarine, attributing modest fat-loss impressions to SR. Similar names and stronger branding do not predict a better result. Reddit r/sarmssourcetalk Reddit r/sarmssourcetalk Personal report
MK-677 did not reliably solve fatigue. After adding 7.5 mg MK-677 nightly, the runner claimed 5–7% faster easy runs. A different reply felt unimproved on GW 4 mg/day and worse after MK 12.5 mg. Carnitine-depletion explanations remain folklore. Personal report Community
Blend labels hide separate contributions. An original vendor example lists MK-2866 20 mg, SR9009 20 mg and GW0742 20 mg per capsule. A separate log lists S4 about 50 mg/day, S23 about 20 mg/day and GW0742 about 10 mg/day, sometimes with testosterone. These are different combinations, not equivalent dose bands. Community
Other stack and bloodwork claims stay qualified. Original discussion includes RAD-140, testosterone/AAS, creatine and L-carnitine alongside GW, plus claims of better lipids, triglycerides or fasting glucose. Multi-agent cuts, calories, sleep and conditioning obscure single-compound credit. '200× stronger' remains marketing, not a verified human comparison. Community Community