STUDresearch · Non-peptide

GW0742

Also known as

GW-0742 · GW 0742 · GW610742 · GW-610742 · Fitorine · Lipoline (forum trade nicknames) · Super Cardarine (community nickname) · Advanced Cardio (vendor branding)

Community talk. May contain inaccuracies. Not medical advice. Not a protocol. Not for human or animal use.

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Non-peptide Niche talk Systemic Oral Metabolic research compounds

Systemic — a whole-body selective PPARδ/β agonist discussed as shifting muscle fuel use toward fatty-acid oxidation, not a local or injection-site agent.

What people say GW0742 is a synthetic PPAR-beta/delta agonist discussed as a Cardarine-adjacent endurance compound. It is not an approved exercise or weight-loss drug, and gray-market identity is a major uncertainty. Doses people talk about

Detailed adverse report10 mg oral daily for three days

The user stopped after cardiovascular and systemic symptoms, then later changed the schedule.

Same-user later report4 mg on Monday and Thursday

The user described effects lasting two to three days and two positive weeks; later benefits were confounded after adding MK-677.

Null-report range10–20 mg oral daily in separate comments

Commenters reported no endurance improvement or no difference from Cardarine; product authenticity was not verified.

These rows document conflicting self-reports and uncertain gray-market identity; they do not define safe, effective or progressive dosing.

Half-life & effect duration

Half-life in the body: Half-lifeNo settled estimate
Felt duration people report: One intermittent-use accountEffects for 2–3 days
Other accountsNo endurance effect
Early adverse accountSymptoms led to stopping by day 3

Timing context & sources

How it may feel Reports span severe symptoms by day 3 at 10 mg/day, modest two-to-three-day effects at a later intermittent amount, benefits only after a confounding MK-677 addition, and complete nonresponse in other accounts.

Cycles people discuss The preserved 8–12 week charts are borrowed community conventions. The most detailed checked account changed schedules within weeks and added another compound, so it cannot validate a standard cycle. Timing Once-daily oral and pre-workout timing are copied from Cardarine culture; a minority split totals between morning and evening. Some vendor notes suggest taking it with food, but the claimed absorption advantage is unsettled. These are unvalidated routines. Stacks Cardarine comparisons dominate the discussion, while SR9009/SR9011 and MK-677 combinations make attribution weaker rather than stronger. Watch for Human long-term gap: No robust multi-year gray-market safety database; short forum use cannot rule out rare or delayed harms.

Tap a line for the full notes and source context.

Timing context & sources

Half-life in the body

No numerical human plasma parent-compound half-life was established in the checked GW0742 source.

A controlled 15 mg oral administration study detected urinary metabolites for up to 20 days and parent compound briefly at low concentration, but its accessible abstract did not report plasma elimination half-life.

Abstract-only review; participant count and full sampling table were unavailable there. Urinary metabolite detection is not parent half-life, biological activity or a dosing interval.

Sobolevsky et al. — Detection and mass spectrometric characterization of novel long-term urinary metabolites of GW0742 (opens in a new tab)Abstract: controlled human excretion study after 15 mg oral GW0742; sulfone metabolites detectable for up to 20 days while parent was briefly present at low urinary concentration.Accessible abstract does not report a plasma half-life, participant count or full concentration-time table; urinary detection duration cannot be converted to pharmacologic duration.

Felt duration people report

Felt duration is disputed: one user later described effects for two to three days on an intermittent schedule, while other users reported no endurance effect at all.

The same detailed author first stopped 10 mg/day on day 3 because of adverse symptoms, later used 4 mg twice weekly and then added MK-677; separate commenters reported null experiences.

Anonymous reports, unverified products, changing schedules, home measurements and multi-compound confounding prevent a reliable duration range.

Reddit r/cardarine — GW0742 in-depth review (opens in a new tab)Original post and same-author updates: adverse stop on day 3 at 10 mg/day, later 4 mg Monday/Thursday with two-to-three-day subjective effects, then an MK-677-confounded update.One evolving uncontrolled account, unverified product, schedule changes, subjective measures, home scale estimates and later polypharmacy.
Reddit r/sarmssourcetalk — GW0742, your experiences (opens in a new tab)Comments include weight loss without endurance, no difference from Cardarine, and no endurance response despite claimed exposure up to 20 mg/day.Sparse anonymous accounts; unknown product authenticity, no objective training protocol or outcome assessment, and possible selection bias.
Reddit r/sarmssourcetalk — SR9011 and GW0742 (opens in a new tab)Original post described injected GW0742 plus SR9011 for about eight weeks and reported little cardiovascular advantage compared with Cardarine.Two-drug combination, unusual unverified route and products, retrospective comparison and no objective or blinded measures.

What people say 12

Endurance talk: Same primary search intent as Cardarine — longer sessions, easier steady-state cardio, less “gas tank empty” feel; public log volume is much smaller. forum
Vs Cardarine reports conflict: One detailed user reported only modest benefit at a later lower intermittent schedule and severe early adverse effects at 10 mg/day; other commenters reported no endurance advantage, including one claiming exposure up to 20 mg/day. Product identity remained uncertain. forum
Fat-loss adjacency: Forums market adipose breakdown / recomp help while preserving lean mass on a cut; diet, cardio volume, and co-drugs usually confound single-agent credit. forum
Non-androgenic appeal: No classic AAS androgen sides (acne/voice/hair from androgen receptor agonism) — draws cutters stacking SARMs who want cardio without more androgen load. forum
Bloodwork anecdotes: Scattered logs claim improved lipids, triglycerides, and fasting glucose on panels during use; sample size tiny and stacks/diet confounded. anecdote
“200× stronger” marketing: Some vendor/forum posts claim up to ~200× potency vs GW501516; published EC50s for both sit near ~1 nM on PPARδ, so structural similarity and near-identical potency argue against that slogan as a literal assay fact. forum
Lipids / cholesterol (mice): ~10 mg/kg GW0742 associated with reverse cholesterol transport and increased fecal excretion of HDL-derived cholesterol in mouse work; not a human lipid-drug claim. animal
Insulin resistance (rats): Intravenous GW0742 lowered plasma glucose/insulin and attenuated elevated HOMA-IR in fructose-rich-diet diabetic rats in a dose-related fashion; blocked by the PPARδ antagonist GSK0660. animal
Anti-inflammatory (rodents): Models report lower leukocyte recruitment and cytokines (e.g., IL-6, IL-1β, TNF-α) at research doses such as ~30 mg/kg in LPS pulmonary inflammation; also gut I/R and pancreatitis models. animal
Pulmonary / right-heart research: GW0742 studied for vessel relaxation and limiting right-heart hypertrophy in hypoxia/PAB-type models (often ~10–30 mg/kg ranges in papers) — research endpoints, not fitness protocols. animal
Neuro / microglial research: Seven-day GW0742 (fitorine) ~5 mg/kg/day i.p. used in rat temporal-lobe epilepsy / neuroinflammation gene-expression work. animal
Human athletic outcomes: Gray-market dosing charts rest on little controlled human performance data; most “results” are self-reports. trial

Doses people talk about 14

Core forum band: Most written protocols copy Cardarine culture at roughly 10–25 mg/day oral, once daily. forum
10 mg/day report: One detailed user stopped after three days because of cardiovascular and systemic symptoms. This is an adverse self-report, not a conservative or safe-dose designation. forum
Lower “typical protocol” talk: Some depth posts/reviews float ~4–10 mg/day as a typical research/user band when marketing claims higher potency. forum
Advanced / high end of charts: ~20–25 mg/day appears as upper community discussion; some logs/coaches claim ~25 mg/day for max endurance push — still anecdote-driven. forum
“Do not exceed” vendor/forum lines: Multiple secondary write-ups say not to go past ~25 mg/day — rule-of-thumb marketing, not a trial MTD. forum
Sex-split vendor charts (unvalidated): Research-chemical sellers sometimes list ~10 mg/day (male subjects) and ~5 mg/day (female subjects) — not from large human trials. forum
Once-daily vs split: Claimed ~24 h half-life drives once-daily dosing for most; a minority split higher totals AM/PM or dose nearer pre-workout for perceived acute coverage. forum
Caps/tabs: 10 mg tablet products appear under various brand names; still research-chemical supply, not pharma. forum
With food: Some vendor blurbs say food may aid absorption; not a settled PK claim. forum
Allometric warning: Do not treat 10 mg/kg rodent doses as 10 mg/kg human doses; community “cancer HED” debates for the sibling compound already show how messy conversion arguments get. forum
Uncertainty / identity risk: Labeled milligrams may not be real GW0742 (underdose, different GW, solvent residue); third-party testing is rare compared with demand. forum
Framing: Community charts, vendor labels, and animal mg/kg only — not medical advice, not validated human protocols, not proof of identity/purity. forum
Route gap in papers: Fitness forums = oral liquids/caps; published work often uses oral gavage, IV (e.g., HOMA-IR rat work to reduce PK noise), or IP in DMSO vehicles. animal
Animal scale (not human recipes): Rodent/work ranges in the literature include sub-mg/kg boluses (e.g., 0.03–0.3 mg/kg in some acute injury models), ~0.3 mg/kg i.p. daily in bleomycin fibrosis work, ~5 mg/kg/day i.p. for multi-day CNS models, ~10 mg/kg for reverse cholesterol transport, and ~10–30 mg/kg oral/systemic in pulmonary-vascular and inflammation papers. animal

How it may feel 8

First days can diverge sharply: One 10 mg/day self-report stopped on day 3 after headache, nausea, thirst, fatigue, irritability, tachycardia and irregular beats; other users reported no endurance effect. forum
Later reports remain mixed: The same user later described two positive weeks on 4 mg twice weekly and then better runs after adding MK-677, while other users reported weight loss without endurance, no difference from Cardarine or no effect. forum
Weeks 3–4: Common keep/stop/switch checkpoint; some compare back-to-back with GW501516 or abandon for better-logged options. forum
Weeks 6–8: Typical end of Cardarine-borrowed blocks; endurance ease may be clearer if product is real and training is cardio-heavy. forum
Weeks 8–12: Vendor/forum upper cycle talk; still not GW0742-specific trial timelines. forum
Potency anecdotes at equal mg: Reports of needing extra carbs in hard sessions to avoid “going hypo” on ~10 mg/day exist alongside “felt nothing” logs — both are anecdotal. anecdote
No change by ~3–4 weeks: Threads question authenticity, under-dosing relative to chart, solvent degradation, or unrealistic expectations rather than endless escalation. forum
Day 0 framing: Not a caffeine-style stim; most expect quiet nuclear-receptor onset over days, not an instant buzz. forum

Cycles people discuss 10

Default culture block: ~8 weeks oral, borrowed wholesale from Cardarine forums. forum
Extended chart range: 8–12 weeks appears on secondary dosage pages and some vendor “research cycle” blurbs. forum
Conservative / probe lengths: 2–4 weeks to compare feel vs GW501516 or to test a new bottle; 4–6 weeks for lower-risk preference. forum
8–10 week self-limits: Some experienced users cap phases around 8–10 weeks at ~10 mg explicitly because of class carcinogenicity debate. forum
Time off: Often match “on” length in risk threads (e.g., 8 on / 8 off); not standardized and not evidence-based for this molecule specifically. forum
No classic AAS PCT: PPARδ agonists are not framed as suppressing HPTA the way androgens do; PCT only enters when stacked with SARMs/AAS. forum
Blast/cruising adjacency: Anecdotes include running GW in final oral weeks of a blast and first 4–6 weeks post-blast as a “cleanup / cardio / lipids” adjunct — multi-agent context. anecdote
Continuous months: A minority report multi-month continuous Cardarine/“Super Cardarine” use; cancer-risk and heart-growth discussions make that controversial even among enthusiasts. forum
Re-runs: Fewer public multi-cycle GW0742 logs than Cardarine; many people try once and return to better-stocked GW501516. forum
Women’s talk: Same class goals at lower chart doses (~5 mg/day vendor talk); almost no dedicated long logs. forum

Timing 9

Why once daily: Long assumed coverage + Cardarine schedule copy; some still prefer pre-workout timing for “feel” even if receptor effects are genomic. forum
Downstream nature: Nuclear-receptor / gene-expression fuel shift — not a short-acting stimulant buzz; training effects are discussed over days–weeks. forum
Carnitine depletion talk (class/forum): Some stack discussions claim GW use depletes carnitine and pair L-carnitine — mechanistic folklore around fat oxidation, not a settled GW0742-specific trial endpoint. forum
Human half-life not established here: A controlled 15 mg oral excretion study found urinary metabolites for up to 20 days but did not report a plasma parent-compound half-life. Urine detectability cannot justify a once-daily schedule. trial
Anti-doping excretion study (human oral 15 mg single dose): Sobolevsky et al. (Drug Test Anal.): parent drug only briefly at low ng/mL; sulfone (bisoxygenated) metabolites are the practical urine targets. trial
Detection windows (same 15 mg oral comparison): GW1516-sulfone reported detectable up to ~40 days; GW0742-sulfone up to ~20 days; urinary abundance of GW0742 and metabolites ~10× lower than GW1516 at equal dose. trial
Sulfoxide:sulfone ratio: Reported to vary irregularly (~1:3 to 1:15) with time after dose — lab method detail, not a user timing tip. trial
Washout of “feel” vs detectability: Subjective endurance ease fading is not the same as metabolite clearance; athletes subject to testing face multi-week risk after a single oral exposure in the cited method. trial
Animal PK caveat: IV vs oral/IP differences matter when reading glucose/IR or inflammation papers — route changes exposure dramatically. animal

Stacks 12

Vs / sequential with Cardarine (GW501516): Most common comparison pair; some alternate trials, few rationalize stacking both PPARδ agonists together (redundant receptor class). forum
+ SR9009 (Stenabolic): Classic endurance/fat-ox research-chem pairing; oral SR9009 bioavailability is itself heavily debated (injectable SR talk in some advanced threads). forum
+ Ostarine (MK-2866): Cut/recomp SARM base + GW for cardio — multi-agent logs. forum
Vendor “Super Lean Stack” example: Marketed fixed blend of MK-2866 20 mg + SR9009 20 mg + GW0742 20 mg per capsule — illustrates ratio culture, not a studied protocol; pre-mixes prevent independent titration. forum
+ Andarine (S4) / S23: Documented log example aiming fat loss while holding weight: S4 ~50 mg/day + S23 ~20 mg/day + GW0742 ~10 mg/day (± test base in that log). anecdote
+ RAD-140: Endurance-coach style stacks in some forums pair GW family compounds with RAD and (sometimes injectable) SR9009 — highly confounded. forum
+ Creatine (HCL or mono): Non-PED pairing frequently praised for training output alongside Cardarine/“Super Cardarine.” forum
+ L-carnitine: Mentioned when carnitine-depletion lore is accepted; evidence quality low. forum
Contest prep / hard cut: High cardio + deficit + often multiple agents — rarely clean single-agent attribution. forum
Testosterone / AAS base: Used as a non-androgenic cardio/fat adjunct under a blast rather than as solo mass gear. forum
Not stacked for PCT: Does not replace SERM/AI logic when androgens are in the stack. forum
Basics still dominate outcomes: Sleep, calories, and conditioning volume get credit whenever results look good. forum

Storage notes 2

No mix instructions here: STUDresearch does not list reconstitution, diluent volumes, or syringe unit charts. People reconstitute many different ways and vial labels differ — that content creates more confusion than clarity. forum
Storage (general talk only): Unopened research products are usually kept cool, dry, and away from light per the seller label. Anything after first use is product-specific — follow the label, not a universal forum SOP. forum

Related 8

Watch for 17

Not a free pass for 0742: Lack of an equally famous GW0742 cancer bioassay in public discussion is not proof of safety — shared mechanism is the point of the caution. forum
Sparse community acute sides: Occasional headache, GI upset, fatigue, oily-skin/acne talk borrowed from Cardarine threads — causality often unclear with polypharmacy. forum
Hypoglycemia-ish training anecdotes: Rare reports of needing extra carbs mid-session on potent-feeling ~10 mg days — still anecdote, not a labeled indication. anecdote
Anecdotal mass / imaging scares: Isolated Reddit-style reports of unexpected findings during/after GW use (e.g., renal masses later called benign) circulate as harm-reduction stories; not established causal epidemiology. anecdote
Source / identity risk: Mislabeling (including vs GW501516), wrong strength, solvent contamination, and underdosing are first-line practical risks. forum
Pregnancy / unknown populations: No responsible community protocol for pregnancy, adolescence, or uncontrolled illness — data vacuum. forum
Polypharmacy stacks: Adding S4/S23/RAD/test/orals multiplies sides and confounds attribution; GW does not cancel androgen toxicity. forum
Class cancer caution (sibling compound): GW501516 multi-organ tumors in long-term high-dose rodent bioassays (GSK abstracts; ~3 mg/kg/day class often cited; ~104-week designs) drove abandonment of clinical development and class-wide wariness for other strong PPARδ agonists including GW0742. animal
Human long-term gap: No robust multi-year gray-market safety database; short forum use cannot rule out rare or delayed harms. trial
Cardiac growth / calcineurin: Wagner et al. and related work link PPARβ/δ stimulation (including GW0742) to rapid cardiac growth and angiogenesis via calcineurin pathways in animal/cell systems — forums translate this into “cardiomegaly” fear language. animal
Context-dependent heart effects: Other models report GW0742 limiting pathological right-heart hypertrophy or improving contractility endpoints — direction depends on model, dose, and disease state; not a green light for unsupervised use. animal
Hepatic / muscle alterations: Faiola et al. found PPARα (more than PPARδ) mediated some hepatic and skeletal-muscle changes after GW0742 — reminder that “selective” is relative at high exposure. animal
Dose-dependent inflammation patterns: Animal literature shows anti-inflammatory benefits in some designs but bidirectional cytokine / response patterns by context and dose. animal
High in-vitro exposure toxicity: Cerebellar neuron and other cell models show neuroprotection at brief exposures but toxicity (e.g., LDH release, c-Jun) after prolonged high concentrations (~100 μM range in classic papers). lab
WADA / sport: PPARδ agonists sit in metabolic-modulator prohibited territory; validated methods detect GW0742 metabolites — sanction risk for tested athletes even after short oral exposure. trial
Not approved / research-only: Not an approved medicine for performance, fat loss, or metabolic disease in standard consumer channels; animal metabolic benefits do not equal human benefit–risk. trial
Australia / scheduling context for sibling: GW501516 has been treated as a high-risk prohibited substance in multiple jurisdictions — social/legal spillover affects how the whole GW family is discussed. trial

Updated: 2026-08-12

Evidence mix Mostly community / anecdote tags Full: every bullet (trial + community). Use Scan for a faster bro-science read.

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Half-life & effect duration

Timing context & sources⌄

Half-life in the body

Felt duration people report

What people say 12

Doses people talk about 14

How it may feel 8

Cycles people discuss 10

Timing 9

More on what it is 9

Stacks 12

Storage notes 2

Related 8

Watch for 17

Timing context & sources