Non-peptide

S-4 (Andarine)

Also known as

Andarine · S4 · GTx-007

Community talk. May contain inaccuracies. Not medical advice. Not a protocol. Not for human or animal use.

What it is

Andarine, S-4 or GTx-007	An oral non-peptide research SARM acting on androgen signals, discussed for retaining muscle during a cut and a harder-looking physique. Selective does not mean harmless.
Capsules and liquids	The saved discussion includes 25 mg capsules and an oral-liquid log. Labeled milligrams do not verify purity or convert directly to milliliters.

Notes

An oral SARM called Andarine. S-4, S4 and GTx-007 refer to the same research compound. SARM means selective androgen receptor modulator: a chemical intended to act on the body's androgen signals, which affect muscle and other tissues. It is a non-peptide compound; 'selective' does not mean harmless. More Plates More Dates Andarine overview (Community guide · Accessed 2026-09-30) · FDA warning about SARMs marketed to teens and young adults (Official context · Accessed 2026-09-30)

Andarine (S-4) is an oral research SARM discussed for keeping muscle during a cut and creating a harder, more defined look. Reports range from better training energy and strength to little expected fat loss. Yellow or green vision and difficulty seeing in the dark are its distinctive community caution.

Capsules and oral liquids are different products. The capsule discussion identifies 25 mg capsules; the training log uses an oral liquid. Milligrams describe labeled Andarine amounts, not milliliters or verified purity. Diet, training and extra compounds complicate before-and-after comparisons. PCT with S4: short-half-life lore, average gains and libido changes (Community discussion · Accessed 2026-09-30) · S4 Andarine log with Ostarine co-use (Personal report · Accessed 2026-09-30)

Source context — More Plates More Dates Andarine overview: Commercial/affiliate creator summary with strong extrapolations; no human trial data substantiates its four-hour assertion, optimal-dose claim or comparative safety. Only its reported community dose range and identity/use vocabulary adopted.

Source context — FDA warning about SARMs marketed to teens and young adults: SARM-class regulatory warning and associated harms; not Andarine-specific incidence, dose-response or a personal diagnosis.

Source context — PCT with S4: short-half-life lore, average gains and libido changes: OP's initial plan is not actual exposure; later actual use distinguished. Enclomiphene confounds the OP outcome. No bloodwork shown to establish suppression/recovery. Advice that PCT is unnecessary or guarantees recovery is not adopted.

Source context — S4 Andarine log with Ostarine co-use: One evolving log, not multiple independent reports; Ostarine, pre-workout, changing doses, training and work schedule confound attribution. Forum contains commercial signatures. Page-one chronology reviewed; later pages not inspected.

What people notice

Harder look and pumps	A week-six 50 mg/day account describes dryness, definition and longer gym pumps. That appearance does not measure fat loss or new muscle.
Strength, endurance and energy	Some report modest strength gains, better endurance or more gym and work energy. One 75 mg account with enclomiphene describes average gains but better mood and confidence.
Expected fat loss did not happen	One five-week account describes larger-looking shoulders and traps and more energy, but no anticipated fat loss, with SR9009 and eating changes also involved.

Notes

Harder-looking muscles and fuller pumps. The week-six 50 mg/day account describes dryness, definition and longer gym pumps. Here 'dry' describes appearance; it does not measure fat loss or prove new muscle tissue. Six-week S4 update: strength and severe night-vision effects (Personal report · Accessed 2026-09-30)

Strength and endurance can change differently. A 30 mg/day contributor describes modest strength gains and better sporting endurance. Other contributors describe much larger strength changes, making a promised size or performance gain unjustified. Andarine S4: different dose experiences and recovery timelines (Community discussion · Accessed 2026-09-30)

More energy does not guarantee more muscle. One stacked account reports better gym and work energy. Another user describes average gains but better mood and confidence during actual 75 mg use with enclomiphene; that is a combined experience. First time on Andarine: a blue-light-filter-like change (Personal report · Accessed 2026-09-30) · PCT with S4: short-half-life lore, average gains and libido changes (Community discussion · Accessed 2026-09-30)

A better gym feeling without the expected fat loss. The five-week contributor reports larger-looking shoulders and traps and more energy, but explicitly says the anticipated fat loss did not happen. SR9009 and eating changes complicate that account; fuller muscles are not the same as losing fat. First time on Andarine: a blue-light-filter-like change (Personal report · Accessed 2026-09-30)

Source context — Six-week S4 update: strength and severe night-vision effects: Not a completed six-week course: the OP planned eight weeks. Removed replies are unavailable. The long-cycle story in a reply is secondhand and was not verified on Instagram; no safety or permanence conclusion adopted.

Source context — Andarine S4: different dose experiences and recovery timelines: Distinct authors and same-author follow-ups kept separate; duplicated deleted comment counted once. Products, dietary conditions and lab claims unverified. Username researchchemsupplies suggests possible commercial interest; no independent proof of affiliation. Recovery accounts do not establish reversible effects for everyone.

Source context — First time on Andarine: a blue-light-filter-like change: Anonymous account, unverified oral research product and SR9009 co-exposure. OP inference of accumulation is not measured elimination; favorable driving description is not a safety assessment.

Doses people talk about

About 25–50 mg/day oral talk	One solo account splits 25 mg morning plus 25 mg evening, totaling 50 mg for the whole day.
30 mg/day; 37.5 mg/day	Separate contributors split these daily totals into two administrations. A no-vision-problem report at 37.5 mg/day does not establish a symptom-free threshold.
Higher amounts	A creator overview describes 25–100 mg/day recreational talk; a separate Reddit account reports 50–75 mg/day. These are examples, not an optimal ladder.

Notes

About 25–50 mg/day orally. The community notes describe this daily band. One solo account specifies 25 mg in the morning plus 25 mg in the evening: 50 mg for the whole day, not 50 mg each time. Andarine S4: a split-dose solo report and commercially affiliated break advice (Community discussion · Accessed 2026-09-30)

30 mg/day and 37.5 mg/day are separate reports. One contributor splits 30 mg into two daily administrations; another splits 37.5 mg/day in half and reports no vision problem. These amounts do not establish a symptom-free threshold. Andarine S4: different dose experiences and recovery timelines (Community discussion · Accessed 2026-09-30)

Higher amounts also appear. The creator overview describes 25–100 mg/day recreational talk. A separate Reddit account describes 50–75 mg/day. These are examples, not a dose ladder or an optimal amount. More Plates More Dates Andarine overview (Community guide · Accessed 2026-09-30) · Andarine S4: different dose experiences and recovery timelines (Community discussion · Accessed 2026-09-30)

Source context — Andarine S4: a split-dose solo report and commercially affiliated break advice: Self-report without product verification or eye assessment. sarmful is a commercial account; break advice is promotional community opinion, not demonstrated prevention. No cycle length supplied by the solo contributor.

Half-life, onset & duration

Felt onset	One log with Ostarine and pre-workout describes benefits in week one; another commenter says after week five. Visual changes appeared in the first week in one log and around week three in another.
Felt duration	No dependable single-dose benefit window is established. After stopping, visual symptoms cleared in a couple of days in one account and about three weeks in another; missed-dose days did not always remove them.
Half-life	A dependable human value is not established. Forum claims span 3–4, 6 or 6–8 hours; a creator's 36–48-hour guess comes from visual recovery. The measured 2.6–5.3-hour range is from rats.

Notes

About a week in one stacked log; later in others. The AnabolicMinds log notices endurance early and calls week one its kick-in period, with Ostarine and pre-workout alongside S-4. Another commenter answers 'after the fifth' week about benefits. No dependable first-dose onset emerges. S4 Andarine log with Ostarine co-use (Personal report · Accessed 2026-09-30) · Andarine S4: different dose experiences and recovery timelines (Community discussion · Accessed 2026-09-30)

Vision changes can arrive on a different timeline. The 50 mg/day five-week account dates its visual changes to roughly week three. The escalating stacked log describes tint within its first week. Early absence of symptoms does not predict the remainder of a course. First time on Andarine: a blue-light-filter-like change (Personal report · Accessed 2026-09-30) · S4 Andarine log with Ostarine co-use (Personal report · Accessed 2026-09-30)

No dependable single-dose benefit window. The accounts describe training changes over repeated days and weeks, not a measured number of useful hours after swallowing one dose. A half-life claim cannot fill that gap. Andarine S4: different dose experiences and recovery timelines (Community discussion · Accessed 2026-09-30) · First time on Andarine: a blue-light-filter-like change (Personal report · Accessed 2026-09-30)

Visual recovery: days in one account, weeks in another. The solo 50 mg/day contributor reports tint clearing a couple of days after stopping. The 20-to-40 mg/day contributor reports about three weeks for vision to normalize. Another still noticed symptoms on missed-dose days. None guarantees a recovery deadline. Andarine S4: a split-dose solo report and commercially affiliated break advice (Community discussion · Accessed 2026-09-30) · Andarine S4: different dose experiences and recovery timelines (Community discussion · Accessed 2026-09-30) · First time on Andarine: a blue-light-filter-like change (Personal report · Accessed 2026-09-30)

3–4 hours, 6 hours, and 6–8 hours circulate. One Reddit reply gives 3–4 hours; a mathematical chart assumes six; the week-six thread has a 6–8-hour assertion. None supplies human blood measurements. Splitting doses does not validate any of these numbers. PCT with S4: short-half-life lore, average gains and libido changes (Community discussion · Accessed 2026-09-30) · Community half-life chart and replies disputing the S4 estimate (Community discussion · Accessed 2026-09-30) · Six-week S4 update: strength and severe night-vision effects (Personal report · Accessed 2026-09-30)

36 or 48 hours is a creator's hypothesis. Derek guesses this from lingering vision changes. Recovery of sight is not a measurement of how quickly blood levels halve, so this competing claim remains a hypothesis; a dependable human half-life is not established here. Derek's S4 half-life hypothesis after lingering vision effects (Personal report · Accessed 2026-09-30) · Community half-life chart and replies disputing the S4 estimate (Community discussion · Accessed 2026-09-30)

The measured 2.6–5.3-hour range is from rats. Kearbey's study measured S-4 under oral and intravenous rat conditions. It provides animal context, not a demonstrated human half-life. Unverified products and combinations also leave long-term effects and interactions uncertain. Kearbey et al. 2004 rat pharmacokinetics abstract (Animal context · Accessed 2026-09-30)

Source context — Community half-life chart and replies disputing the S4 estimate: Chart assumptions and arithmetic are not pharmacokinetic observations; the 100 mg example is not counted as a user's dose. Multiple repetitions of Derek's hypothesis are not independent evidence.

Source context — Derek's S4 half-life hypothesis after lingering vision effects: Personal creator experiment on a site with recommended products, discount codes and affiliate disclosure. The numerical half-life is explicitly an educated guess from symptom persistence. It does not validate human kinetics or a new regimen.

Source context — Kearbey et al. 2004 rat pharmacokinetics abstract: Primary abstract accessed through Europe PMC API; direct PMC/PubMed full-text pages blocked. Rat measurements are not human half-life or an oral human dosing schedule.

Cycles people discuss

Six-to-eight-week discussion	Examples include six- and seven-week courses and a week-six update with two more weeks planned. These are reported use, not validated course or recovery lengths.
Five on, two off claim	A commercially affiliated commenter suggests five days on and two off for vision effects. No controlled comparison or reliable visual-recovery guarantee supports that break advice.

Notes

Six to eight weeks appears in the discussion. Examples include a six-week course, a seven-week 50 mg/day account, and a week-six update with two weeks still planned. These describe use, not validated course lengths or recovery schedules. Andarine S4: different dose experiences and recovery timelines (Community discussion · Accessed 2026-09-30) · PCT with S4: short-half-life lore, average gains and libido changes (Community discussion · Accessed 2026-09-30) · Six-week S4 update: strength and severe night-vision effects (Personal report · Accessed 2026-09-30)

Five days on, two off is unproven break advice. A commercially affiliated Reddit account suggests this to reduce vision effects. It supplies no controlled comparison. These discussions establish neither a universal off-period nor a guarantee that short breaks restore normal vision. Andarine S4: a split-dose solo report and commercially affiliated break advice (Community discussion · Accessed 2026-09-30) · First time on Andarine: a blue-light-filter-like change (Personal report · Accessed 2026-09-30)

Stacks

Cardarine	Appears in cutting-stack lore; the saved record does not establish a safe or effective combination.
SR9009 or Ostarine	Actual logs contain these co-ingredients. One escalating Ostarine/S-4 log reached 100 mg/day S-4 with worse vision, joint pain and lower strength by day fourteen.
Enclomiphene	One actual 75 mg S-4 account also used enclomiphene, so its mood, confidence and gain reports concern combined use.

Notes

With Cardarine: Classic cut stack lore. [community]

Stacks make both benefits and symptoms harder to untangle. Cardarine appears in cutting-stack discussion; actual logs also contain SR9009 or Ostarine. A solo report is easier to interpret, but none of these accounts establishes safe combinations, authentic contents or lasting gains. First time on Andarine: a blue-light-filter-like change (Personal report · Accessed 2026-09-30)

More did not keep improving one stacked log. At 100 mg/day with Ostarine alongside S-4, the oral-liquid author described worse vision, joint pain and lower strength by day fourteen. The earlier endurance benefit and later deterioration belong to one changing account. S4 Andarine log with Ostarine co-use (Personal report · Accessed 2026-09-30)

Deleted reply line 50 repeats '3 or 4 hours' without measurements. Not-Manager OP 21 and reply 61 identify 25 mg capsules; later same-author replies 101–118 report actual 75 mg use with enclomiphene, light-to-dark difficulty and average gains but improved mood. Independent_Sink_566 at 143: 50 mg/day for seven weeks, libido dip for two weeks after stopping. PCT with S4: short-half-life lore, average gains and libido changes (Community discussion · Accessed 2026-09-30)

Watch for

Night vision and tint	Yellow or green tint, poor dark adaptation and morning shadowed areas are distinctive reports. Vision loss or new dark patches need medical assessment; lower amounts do not establish safe night driving.
Hormones, cholesterol and libido	Suppression and cholesterol concerns remain despite a mild reputation. One seven-week user reported reduced libido for about two weeks after stopping; it does not set a recovery deadline.
Unapproved SARM risks	The saved FDA class warning includes liver and cardiovascular problems, sexual dysfunction, infertility and pregnancy miscarriage. Unverified Andarine products have uncertain long-term effects.
Severe symptoms	Severe allergy, chest pain, neurological changes or uncontrolled blood pressure or glucose require medical assessment.

Notes

Night vision can become a serious practical problem. Accounts include poor dark adaptation, green or yellow tint and morning shadowed areas. Vision loss or new dark patches need medical assessment; neither a reassuring post nor a lower amount makes night driving safe. Six-week S4 update: strength and severe night-vision effects (Personal report · Accessed 2026-09-30) · Vision problems from S4 while driving at night (Community discussion · Accessed 2026-09-30)

Suppression and cholesterol deserve more than a 'mild' label. Community notes raise hormone and cholesterol concerns. Feeling well or a blood test months later does not establish normal hormone production throughout use. Post-cycle therapy (PCT) means attempts to restore hormone production afterward; forum schedules are not validated recovery treatments. Andarine S4: different dose experiences and recovery timelines (Community discussion · Accessed 2026-09-30) · PCT with S4: short-half-life lore, average gains and libido changes (Community discussion · Accessed 2026-09-30)

Libido can change after the course ends. The seven-week 50 mg/day contributor describes about two weeks of reduced libido after stopping, then recovery. That one timeline cannot establish anyone else's hormone recovery or whether PCT is needed. PCT with S4: short-half-life lore, average gains and libido changes (Community discussion · Accessed 2026-09-30)

Unapproved status and long-term uncertainty matter. FDA identifies SARMs as unapproved drugs that cannot be legally marketed as U.S. dietary supplements. Its class warning includes liver and cardiovascular problems, sexual dysfunction, infertility and pregnancy miscarriage. Long-term effects of unverified Andarine products remain uncertain. FDA warning about SARMs marketed to teens and young adults (Official context · Accessed 2026-09-30)

Severe symptoms need medical care. Severe allergy, chest pain, neurological changes, or uncontrolled blood pressure or glucose require medical assessment rather than forum troubleshooting.

Source context — Vision problems from S4 while driving at night: Unverified report; sponsor/vendor links and sponsored athlete signatures make commercial influence material. Neither moderator reassurance nor an absence of symptoms at 25 mg establishes a safe threshold.

Full notes

What S-4 is and why people discuss it

An oral SARM called Andarine. S-4, S4 and GTx-007 refer to the same research compound. SARM means selective androgen receptor modulator: a chemical intended to act on the body's androgen signals, which affect muscle and other tissues. It is a non-peptide compound; 'selective' does not mean harmless. Community Community guide Official context
Cutting and recomp are the main appeal. Cutting means trying to lose fat while keeping muscle; recomp means seeking less fat and more muscle together. The attraction in these accounts is a firmer, more defined appearance, rather than a predictable stimulant-like feeling. Reddit Personal report
Capsules and oral liquids are different products. The capsule discussion identifies 25 mg capsules; the training log uses an oral liquid. Milligrams describe labeled Andarine amounts, not milliliters or verified purity. Diet, training and extra compounds complicate before-and-after comparisons. Reddit Personal report Community

Benefits people seek and report

Harder-looking muscles and fuller pumps. The week-six 50 mg/day account describes dryness, definition and longer gym pumps. Here 'dry' describes appearance; it does not measure fat loss or prove new muscle tissue. Personal report
Strength and endurance can change differently. A 30 mg/day contributor describes modest strength gains and better sporting endurance. Other contributors describe much larger strength changes, making a promised size or performance gain unjustified. Reddit
More energy does not guarantee more muscle. One stacked account reports better gym and work energy. Another user describes average gains but better mood and confidence during actual 75 mg use with enclomiphene; that is a combined experience. Personal report Reddit

Doses people discuss

About 25–50 mg/day orally. The community notes describe this daily band. One solo account specifies 25 mg in the morning plus 25 mg in the evening: 50 mg for the whole day, not 50 mg each time. Community Reddit
30 mg/day and 37.5 mg/day are separate reports. One contributor splits 30 mg into two daily administrations; another splits 37.5 mg/day in half and reports no vision problem. These amounts do not establish a symptom-free threshold. Reddit
Higher amounts also appear. The creator overview describes 25–100 mg/day recreational talk. A separate Reddit account describes 50–75 mg/day. These are examples, not a dose ladder or an optimal amount. Community guide Reddit

Half-life claims in community discussion

3–4 hours, 6 hours, and 6–8 hours circulate. One Reddit reply gives 3–4 hours; a mathematical chart assumes six; the week-six thread has a 6–8-hour assertion. None supplies human blood measurements. Splitting doses does not validate any of these numbers. Reddit Reddit Personal report
36 or 48 hours is a creator's hypothesis. Derek guesses this from lingering vision changes. Recovery of sight is not a measurement of how quickly blood levels halve, so this competing claim remains a hypothesis; a dependable human half-life is not established here. Personal report Reddit

When people notice changes

About a week in one stacked log; later in others. The AnabolicMinds log notices endurance early and calls week one its kick-in period, with Ostarine and pre-workout alongside S-4. Another commenter answers 'after the fifth' week about benefits. No dependable first-dose onset emerges. Personal report Reddit
Vision changes can arrive on a different timeline. The 50 mg/day five-week account dates its visual changes to roughly week three. The escalating stacked log describes tint within its first week. Early absence of symptoms does not predict the remainder of a course. Personal report Personal report

How long effects remain noticeable

No dependable single-dose benefit window. The accounts describe training changes over repeated days and weeks, not a measured number of useful hours after swallowing one dose. A half-life claim cannot fill that gap. Reddit Personal report
Visual recovery: days in one account, weeks in another. The solo 50 mg/day contributor reports tint clearing a couple of days after stopping. The 20-to-40 mg/day contributor reports about three weeks for vision to normalize. Another still noticed symptoms on missed-dose days. None guarantees a recovery deadline. Reddit Reddit Personal report

Courses and breaks people describe

Six to eight weeks appears in the discussion. Examples include a six-week course, a seven-week 50 mg/day account, and a week-six update with two weeks still planned. These describe use, not validated course lengths or recovery schedules. Community Reddit Reddit Personal report
Five days on, two off is unproven break advice. A commercially affiliated Reddit account suggests this to reduce vision effects. It supplies no controlled comparison. These discussions establish neither a universal off-period nor a guarantee that short breaks restore normal vision. Reddit Community Personal report

Visual, hormonal and product risks

Night vision can become a serious practical problem. Accounts include poor dark adaptation, green or yellow tint and morning shadowed areas. Vision loss or new dark patches need medical assessment; neither a reassuring post nor a lower amount makes night driving safe. Personal report Anabolex Community
Suppression and cholesterol deserve more than a 'mild' label. Community notes raise hormone and cholesterol concerns. Feeling well or a blood test months later does not establish normal hormone production throughout use. Post-cycle therapy (PCT) means attempts to restore hormone production afterward; forum schedules are not validated recovery treatments. Community Reddit Reddit
Unapproved status and long-term uncertainty matter. FDA identifies SARMs as unapproved drugs that cannot be legally marketed as U.S. dietary supplements. Its class warning includes liver and cardiovascular problems, sexual dysfunction, infertility and pregnancy miscarriage. Long-term effects of unverified Andarine products remain uncertain. Official context Community
Severe symptoms need medical care. Severe allergy, chest pain, neurological changes, or uncontrolled blood pressure or glucose require medical assessment rather than forum troubleshooting. Community
The measured 2.6–5.3-hour range is from rats. Kearbey's study measured S-4 under oral and intravenous rat conditions. It provides animal context, not a demonstrated human half-life. Unverified products and combinations also leave long-term effects and interactions uncertain. Animal context Community

From community experience

A better gym feeling without the expected fat loss. The five-week contributor reports larger-looking shoulders and traps and more energy, but explicitly says the anticipated fat loss did not happen. SR9009 and eating changes complicate that account; fuller muscles are not the same as losing fat. Personal report
Vision severity has no reliable dose cutoff. One 37.5 mg/day contributor reports no vision trouble. Another describes weak results at 20 mg/day, then stronger training effects and serious visual changes at 40 mg/day. Different products and exposure lengths prevent a safe cutoff. Reddit
Comparisons with RAD-140 and LGD-4033 disagree. One person calls S-4 stronger than RAD-140 (Testolone) and comparable to LGD-4033 (Ligandrol) without bloat; another sees it as a middle ground. These are personal comparisons, not head-to-head trials or a reliable ranking. Reddit
Libido can change after the course ends. The seven-week 50 mg/day contributor describes about two weeks of reduced libido after stopping, then recovery. That one timeline cannot establish anyone else's hormone recovery or whether PCT is needed. Reddit
More did not keep improving one stacked log. At 100 mg/day with Ostarine alongside S-4, the oral-liquid author described worse vision, joint pain and lower strength by day fourteen. The earlier endurance benefit and later deterioration belong to one changing account. Personal report
Stacks make both benefits and symptoms harder to untangle. Cardarine appears in cutting-stack discussion; actual logs also contain SR9009 or Ostarine. A solo report is easier to interpret, but none of these accounts establishes safe combinations, authentic contents or lasting gains. Community Personal report