Non-peptide

RAD-140

Also known as

Testolone · RAD140 · RAD 140 · Vosilasarm (INN / development naming) · EP0062 (reformulated clinical code) · Testalone (common misspelling in literature and forums) · Radius RAD140 (developer-adjacent search string)

Community talk. May contain inaccuracies. Not medical advice. Not a protocol. Not for human or animal use.

What it is

Testolone oral SARM	RAD-140 is an investigational nonsteroidal androgen-receptor modulator discussed for muscle and strength. It is not testosterone or a peptide; selectivity does not confine effects to muscle.
Liquids and solid forms	Oral liquids, capsules and tablets appear. Milligrams name drug amount and milliliters name volume; formulation, concentration and uncertain contents prevent treating bottles as interchangeable.

Notes

RAD-140, also called Testolone, is an investigational oral SARM discussed for muscle and strength. People describe stronger lifts, fuller pumps or keeping strength during a cut; others notice little change or stop because of unwanted effects. Hormone suppression, liver injury and uncertain product contents are central concerns.

An androgen-receptor drug. SARM means selective androgen receptor modulator: it activates the signaling system involved in androgen effects. RAD-140 is a nonsteroidal small molecule, not a peptide or testosterone. Tissue selectivity does not mean effects stay confined to muscle. LoRusso et al.: first-in-human RAD140 Phase I study (Official context · Accessed 2026-09-30) · Miller et al.: preclinical characterization of RAD140 (Animal context · Accessed 2026-09-30)

Oral liquids, capsules and tablets. These are the forms discussed in gym communities. Labeled milligrams describe a claimed drug amount; milliliters describe liquid volume. Different concentrations, formulations and uncertain contents prevent treating bottles as interchangeable.

Source context — LoRusso et al.: first-in-human RAD140 Phase I study: Abstract only, not full paper; clinical formulation, cancer population and amounts cannot establish gym outcomes, gray-market product equivalence or safe recreational use.

Source context — Miller et al.: preclinical characterization of RAD140: Animal and laboratory experiments with small groups; neither recreational efficacy nor human safe dose. Developer affiliations; no community half-life supplied.

What people notice

Strength and fuller pumps	Some report stronger lifts, more reps or maintained strength during a cut. A drier look than LGD and stronger effects than Ostarine are community impressions, not head-to-head findings.
Little change or disrupted sleep	One reviewer noticed no strength change for two weeks, then progress in weeks 3–4 while changing the amount. Sleep problems can start early, later or not at all.

Notes

Strength and muscle retention during a cut. One eight-week reviewer described more reps and stronger lifts despite calorie restriction. Their training, dose changes and return from injury complicate attribution; the report does not establish how much muscle was gained or fat lost. RAD-140 cycle review, no PCT (Personal report · Accessed 2026-09-30)

Lean size and a drier look. Community comparisons portray RAD as stronger than Ostarine and less watery than LGD-4033. These are physique impressions, not head-to-head findings. Fuller pumps and motivation feature in reports, alongside irritability or lethargy. Bloodwork saved my ass (Personal report · Accessed 2026-09-30)

No strength change for two weeks, then more reps. The solo reviewer noticed progress in weeks 3–4 while also changing the amount. Another opened thread’s title reports no felt changes after more than 20 days, but supplies no exposure details. RAD-140 cycle review, no PCT (Personal report · Accessed 2026-09-30) · RAD140 non responder after more than 20 days (Personal report · Accessed 2026-09-30)

Sleep problems can appear before desired gains. Replies describe insomnia from day one, later in a course or not at all. A forum author described lethargy and workout activation during the first week. These observations do not establish a predictable onset. When does insomnia start to appear? (Community discussion · Accessed 2026-09-30) · RAD-140 sleep issues, insomnia and side effects (Personal report · Accessed 2026-09-30)

Source context — RAD-140 cycle review, no PCT: Anonymous uncontrolled cut-phase report; no bloodwork, product assay or body-composition scan; changing amount, return from injury and training confound effects. No vendor recommendation retained.

Source context — Bloodwork saved my ass: Anonymous stacked exposure and self-reported labs without assay; ALT unit absent in accessible post; contamination remains a possibility, not confirmed. Thread date supported by Reddit dated archive link.

Source context — RAD140 non responder after more than 20 days: Title-only first-person report within an opened thread; amount, training, product and exact publication date unavailable. No diagnosis of biological nonresponse; relative 2h timestamp not converted to a date.

Source context — When does insomnia start to appear?: Anonymous comments with varying exposure and little objective sleep data; mechanisms asserted in replies are unverified. DeusMedical vendor reply promoting tamoxifen excluded.

Source context — RAD-140 sleep issues, insomnia and side effects: Unverified labels and uncontrolled reports; proposed 8–12-hour stimulation mechanism is speculation, not measured timing. Posts are separate experiences.

Doses people talk about

Oral chart bands	5–10, 10–20 and 20–30 mg/day appear, usually once daily. Beginner/intermediate/aggressive labels are forum categories, not validated experience levels or safe-dose bands.
Specific logs	One eight-week log progressed from 10 to 15, 20 and 25 mg/day. A separate liver-event author reported 10 mg RAD plus 6.25 mg enclomiphene daily; neither establishes a regimen.
Sparse women's reports	5–10 mg/day appears with concern about voice changes, hair growth and other masculinizing effects. Sparse reporting does not establish safety, and some changes may persist.

Notes

5–10, 10–20 and 20–30 mg/day oral bands. Community charts describe these as starting, intermediate and aggressive amounts, respectively, usually once daily. Those labels are forum categories, not validated experience levels or safe doses; escalation is not proof of a better result.

One log progressed from 10 to 25 mg/day. The eight-week reviewer reported 10 mg initially, then 15, 20 and finally 25 mg/day. A separate liver-event author reported 10 mg RAD daily plus 6.25 mg enclomiphene daily. Neither account establishes a regimen. RAD-140 cycle review, no PCT (Personal report · Accessed 2026-09-30) · Bloodwork saved my ass (Personal report · Accessed 2026-09-30)

Sparse women’s reports mention 5–10 mg/day. Community discussion pairs those amounts with concern about voice changes, hair growth and other masculinizing effects. Sparse reporting does not establish safety, and some changes can persist.

Half-life, onset & duration

Felt onset	One reviewer saw more reps in weeks 3–4 after no strength change in the first two weeks. Insomnia can precede desired gains; the record supplies no dependable onset clock.
Felt duration	No reliable single-dose window. Some report sleep improving within days of stopping, while drive and recovery worsen; retained strength weeks later does not establish hormone recovery.
Half-life	16–20 and about 60 hours circulate. A clinical formulation measured 44.7 hours in metastatic breast-cancer patients; none verifies clearance of labeled gym products.

Notes

There is no reliable single-dose feel window. Reports describe training and sleep across days or weeks rather than a timed effect after one oral dose. Bodily half-life, noticeable stimulation and retained strength answer different questions. RAD-140 cycle review, no PCT (Personal report · Accessed 2026-09-30) · RAD-140 sleep issues, insomnia and side effects (Personal report · Accessed 2026-09-30) · Rad140 cycle: 20-hour versus 60-hour debate (Secondhand community claim · Accessed 2026-09-30)

Sleep and training can change after stopping. One forum author reported normal sleep two days after stopping. The solo reviewer described better sleep within days but lower drive and slower recovery during the first week, with strength largely retained four weeks later. Enclo and Radsomnia (Personal report · Accessed 2026-09-30) · RAD-140 cycle review, no PCT (Personal report · Accessed 2026-09-30)

Hormone recovery can take longer than the last dose. Community accounts discuss weeks to months of recovery and variable retention of size. These are reported timelines; felt recovery alone does not establish restored hormone levels.

16–20 hours versus about 60 hours circulate. Older charts repeat 16–20 hours. An opened Reddit discussion repeats 20 and 60 hours and directs readers to a More Plates More Dates video. These are circulated research interpretations, not measurements made in those users. Rad140 cycle: 20-hour versus 60-hour debate (Secondhand community claim · Accessed 2026-09-30)

No measured half-life for the labeled gym products. The discussion debates daily versus every-other-day use on the basis of these numbers. It cannot establish a product’s actual clearance, a preferred interval or the duration of a felt benefit. Rad140 cycle: 20-hour versus 60-hour debate (Secondhand community claim · Accessed 2026-09-30)

44.7 hours was measured in an oncology study. This measured value comes from clinical oral RAD-140 in 22 postmenopausal metastatic breast-cancer patients. AST, ALT and bilirubin elevations also occurred. It cannot establish the clearance or safety of unverified gym products. LoRusso et al.: first-in-human RAD140 Phase I study (Official context · Accessed 2026-09-30)

Source context — Rad140 cycle: 20-hour versus 60-hour debate: Secondhand interpretation of research/video, not community pharmacokinetic measurement. Video itself not inspected. Vendor BuyDeus comments and sales link present; their PCT sales advice excluded.

Source context — Enclo and Radsomnia: Amount frequency not explicit in post; do not upgrade 20 mg to verified daily amount. Co-use, new-job stress and no hormone testing prevent attribution. Commercial forum surroundings.

Cycles people discuss

Forum blocks	6–8 weeks recurs, with 4–6-week introductions and 8–12-week bulk-style runs also described. Adverse effects can interrupt a course much earlier.
Recovery debate	Tamoxifen, clomiphene and enclomiphene appear in post-cycle discussion. Starting soon after stopping versus 5–14 days later and off-time at least as long as on-time are disputed customs, not validated recovery protocols.

Notes

Six to eight weeks is a common forum pattern. Community accounts also include 4–6-week introductory runs and 8–12-week bulk-style runs. These are recreational discussion windows, not clinical treatment courses; adverse effects can interrupt them much earlier. Enclo and Radsomnia (Personal report · Accessed 2026-09-30)

Post-cycle therapy is heavily debated. Tamoxifen, clomiphene and enclomiphene appear in recovery discussions. Suggested starts range from soon after the last dose to roughly 5–14 days later, reflecting conflicting clearance claims. No inspected thread validates a recovery protocol. Rad140 cycle: 20-hour versus 60-hour debate (Secondhand community claim · Accessed 2026-09-30)

Time off and bloodwork are separate from feeling fine. Off-time at least as long as on-time is a forum rule of thumb. Logs discuss pre-, mid- and post-course hormones, lipids and liver markers, while bridges or testosterone-base use introduce further exposures. Bloodwork saved my ass (Personal report · Accessed 2026-09-30)

Stacks

MK-677	Mass-goal charts pair RAD 10–20 mg/day with MK-677 10–25 mg/day. Appetite, water retention, glucose and sleep changes complicate both positive and negative accounts.
Other SARMs or testosterone	LGD-4033, Ostarine, YK-11, S-4, cardarine and testosterone appear in combination lists. They bring distinct risks and prevent isolating RAD's contribution; cardarine is not a SARM.
Support supplements	TUDCA, NAC, milk thistle, fish oil and citrus bergamot recur. They do not certify protection; the reported liver-event user had taken NAC and milk thistle.

Notes

Stacks change the story. Community charts pair RAD 10–20 mg/day with MK-677 10–25 mg/day for mass goals; hunger, water retention and glucose concerns complicate the picture. LGD-4033, Ostarine, YK-11, S-4, cardarine and testosterone also appear, with distinct risks and uncertain attribution.

Sleep can differ between courses. One Reddit author slept well during a first course with MK-677 but poorly during a later RAD-only course at the same stated 10 mg/day. Other commenters describe unchanged sleep. Amount alone cannot explain that difference. Insomnia on rad140 (Personal report · Accessed 2026-09-30) · When does insomnia start to appear? (Community discussion · Accessed 2026-09-30)

RAD + cardarine (GW-501516): Cutting/recomp + endurance/fat-oxidation narrative; GW is not a SARM and carries its own long-term safety debates. [community]

Support products and monitoring do different jobs. TUDCA, NAC, milk thistle, fish oil and citrus bergamot appear in support discussions. They do not certify protection. The bloodwork author’s clinician reportedly questioned whether the product actually contained RAD-140; neither the harm nor gains identify its contents. Bloodwork saved my ass (Personal report · Accessed 2026-09-30)

Feeling good does not rule out liver injury. The 10 mg/day stacked author reported strong pumps and motivation before ALT reached 417, with the unit unstated. NAC and milk thistle had not prevented the reported elevation; the author stopped and later reported falling enzymes. Bloodwork saved my ass (Personal report · Accessed 2026-09-30)

Source context — Insomnia on rad140: Same labeled amount does not establish equal exposure; different co-use and unknown product identity. Replies urging adaptation or sleep-aid use are not safety evidence.

Watch for

Liver injury despite feeling good	One stacked 10 mg/day author reported strong pumps before ALT reached 417, with unit unstated. A published case describes severe jaundice and itching with months-long recovery.
Hormones, mood and sleep	Reports include suppression, low libido, erectile problems, fatigue, post-course crash, irritability, anxiety, acne, hair shedding and disrupted sleep. Feeling recovered does not measure hormone restoration.
Lipids, identity and persistent effects	Lower milligrams and support products do not establish safety. Lipid deterioration, uncertain contents, long-term cardiovascular unknowns and potentially persistent masculinizing changes remain concerns.

Notes

Selective does not mean liver-safe or hormone-safe. A published case describes severe jaundice and itching after a reported two-month exposure, with recovery over months. A single case cannot estimate frequency; product uncertainty does not erase the clinical warning. Perananthan and George: severe liver injury following RAD-140 use (Official context · Accessed 2026-09-30)

Suppression and sexual effects matter. Low libido, fatigue, erectile problems and a post-course crash appear in community accounts. Acne, hair shedding, anxiety, irritability, sleep disruption and blood-pressure concerns also feature. Symptom timing alone cannot identify their cause.

Lower milligrams and support supplements are not safety guarantees. The actual substance and concentration may differ from the label. Lipid deterioration and long-term cardiovascular unknowns remain concerns, and women’s discussion includes potentially persistent virilization effects. Bloodwork saved my ass (Personal report · Accessed 2026-09-30)

Source context — Perananthan and George: severe liver injury following RAD-140 use: One probable drug-injury case with unassayed product and no incidence estimate. PMC mirror recheck hit CAPTCHA; publisher full text was read.

Full notes

What RAD-140 is

An androgen-receptor drug. SARM means selective androgen receptor modulator: it activates the signaling system involved in androgen effects. RAD-140 is a nonsteroidal small molecule, not a peptide or testosterone. Tissue selectivity does not mean effects stay confined to muscle. Official context Animal context
Oral liquids, capsules and tablets. These are the forms discussed in gym communities. Labeled milligrams describe a claimed drug amount; milliliters describe liquid volume. Different concentrations, formulations and uncertain contents prevent treating bottles as interchangeable. Community Community

Why people look it up

Strength and muscle retention during a cut. One eight-week reviewer described more reps and stronger lifts despite calorie restriction. Their training, dose changes and return from injury complicate attribution; the report does not establish how much muscle was gained or fat lost. Personal report
Lean size and a drier look. Community comparisons portray RAD as stronger than Ostarine and less watery than LGD-4033. These are physique impressions, not head-to-head findings. Fuller pumps and motivation feature in reports, alongside irritability or lethargy. Community Personal report

Doses people discuss

5–10, 10–20 and 20–30 mg/day oral bands. Community charts describe these as starting, intermediate and aggressive amounts, respectively, usually once daily. Those labels are forum categories, not validated experience levels or safe doses; escalation is not proof of a better result. Community
One log progressed from 10 to 25 mg/day. The eight-week reviewer reported 10 mg initially, then 15, 20 and finally 25 mg/day. A separate liver-event author reported 10 mg RAD daily plus 6.25 mg enclomiphene daily. Neither account establishes a regimen. Personal report Personal report
Sparse women’s reports mention 5–10 mg/day. Community discussion pairs those amounts with concern about voice changes, hair growth and other masculinizing effects. Sparse reporting does not establish safety, and some changes can persist. Community Community

Half-life: competing claims

16–20 hours versus about 60 hours circulate. Older charts repeat 16–20 hours. An opened Reddit discussion repeats 20 and 60 hours and directs readers to a More Plates More Dates video. These are circulated research interpretations, not measurements made in those users. Community Reddit r/rad140
No measured half-life for the labeled gym products. The discussion debates daily versus every-other-day use on the basis of these numbers. It cannot establish a product’s actual clearance, a preferred interval or the duration of a felt benefit. Reddit r/rad140

When people notice a change

No strength change for two weeks, then more reps. The solo reviewer noticed progress in weeks 3–4 while also changing the amount. Another opened thread’s title reports no felt changes after more than 20 days, but supplies no exposure details. Personal report Personal report
Sleep problems can appear before desired gains. Replies describe insomnia from day one, later in a course or not at all. A forum author described lethargy and workout activation during the first week. These observations do not establish a predictable onset. Reddit r/rad140 Personal report

How long effects seem to last

There is no reliable single-dose feel window. Reports describe training and sleep across days or weeks rather than a timed effect after one oral dose. Bodily half-life, noticeable stimulation and retained strength answer different questions. Personal report Personal report Reddit r/rad140
Sleep and training can change after stopping. One forum author reported normal sleep two days after stopping. The solo reviewer described better sleep within days but lower drive and slower recovery during the first week, with strength largely retained four weeks later. Personal report Personal report
Hormone recovery can take longer than the last dose. Community accounts discuss weeks to months of recovery and variable retention of size. These are reported timelines; felt recovery alone does not establish restored hormone levels. Community

Course lengths and recovery debates

Six to eight weeks is a common forum pattern. Community accounts also include 4–6-week introductory runs and 8–12-week bulk-style runs. These are recreational discussion windows, not clinical treatment courses; adverse effects can interrupt them much earlier. Community Personal report
Post-cycle therapy is heavily debated. Tamoxifen, clomiphene and enclomiphene appear in recovery discussions. Suggested starts range from soon after the last dose to roughly 5–14 days later, reflecting conflicting clearance claims. No inspected thread validates a recovery protocol. Community Reddit r/rad140
Time off and bloodwork are separate from feeling fine. Off-time at least as long as on-time is a forum rule of thumb. Logs discuss pre-, mid- and post-course hormones, lipids and liver markers, while bridges or testosterone-base use introduce further exposures. Community Personal report

Good to know before interpreting a log

Feeling good does not rule out liver injury. The 10 mg/day stacked author reported strong pumps and motivation before ALT reached 417, with the unit unstated. NAC and milk thistle had not prevented the reported elevation; the author stopped and later reported falling enzymes. Personal report
Suppression and sexual effects matter. Low libido, fatigue, erectile problems and a post-course crash appear in community accounts. Acne, hair shedding, anxiety, irritability, sleep disruption and blood-pressure concerns also feature. Symptom timing alone cannot identify their cause. Community Community
Selective does not mean liver-safe or hormone-safe. A published case describes severe jaundice and itching after a reported two-month exposure, with recovery over months. A single case cannot estimate frequency; product uncertainty does not erase the clinical warning. Official context
Lower milligrams and support supplements are not safety guarantees. The actual substance and concentration may differ from the label. Lipid deterioration and long-term cardiovascular unknowns remain concerns, and women’s discussion includes potentially persistent virilization effects. Community Personal report

What the reports add

Sleep can differ between courses. One Reddit author slept well during a first course with MK-677 but poorly during a later RAD-only course at the same stated 10 mg/day. Other commenters describe unchanged sleep. Amount alone cannot explain that difference. Personal report Reddit r/rad140
A short run can still be disruptive. An AnabolicMinds author stopped just over two weeks in because of insomnia and lost libido. The thread also raised co-use and new-job stress, illustrating why a plausible association is not a confirmed cause. Personal report
Keeping gains is different from confirming recovery. The solo reviewer reported retained strength without post-cycle drugs, despite reduced motivation and recovery. Replies disputed that decision; there were no hormone measurements. A good-looking result cannot establish absence of suppression. Personal report
Stacks change the story. Community charts pair RAD 10–20 mg/day with MK-677 10–25 mg/day for mass goals; hunger, water retention and glucose concerns complicate the picture. LGD-4033, Ostarine, YK-11, S-4, cardarine and testosterone also appear, with distinct risks and uncertain attribution. Community
Support products and monitoring do different jobs. TUDCA, NAC, milk thistle, fish oil and citrus bergamot appear in support discussions. They do not certify protection. The bloodwork author’s clinician reportedly questioned whether the product actually contained RAD-140; neither the harm nor gains identify its contents. Community Personal report

Clinical and animal research

44.7 hours was measured in an oncology study. This measured value comes from clinical oral RAD-140 in 22 postmenopausal metastatic breast-cancer patients. AST, ALT and bilirubin elevations also occurred. It cannot establish the clearance or safety of unverified gym products. Official context
EP0062 is a reformulated clinical product. The ASCO 2025 poster describes EP0062 with improved bioavailability. Different formulations can produce different exposure, so its clinical findings do not validate gym products. Official context
Animal findings explain the selectivity claim’s limits. Rat experiments showed differing muscle and prostate responses; a small 28-day monkey experiment also showed testosterone suppression and HDL decreases. These are preclinical findings, not human dose, half-life or physique measurements. Animal context