Non-peptide

ACP-105

Also known as

ACP105 · ACP 105 · Acadia SARM ACP-105 · non-steroidal SARM ACP-105 · 2-chloro-4-[(3-endo)-3-hydroxy-3-methyl-8-azabicyclo[3.2.1]oct-8-yl]-3-methylbenzonitrile · CAS 1048998-11-3

Community talk. May contain inaccuracies. Not medical advice. Not a protocol. Not for human or animal use.

What it is

Experimental oral SARM	ACP-105 acts at androgen receptors. People discuss it for muscle retention, gym pumps and a leaner, drier look.
Liquids and capsules	The accounts concern unapproved research products. Animal muscle selectivity does not mean effects stay in muscle or avoid hormones elsewhere.

Notes

ACP-105 is an experimental oral SARM discussed for muscle retention, gym pumps and a leaner, drier appearance. Experiences range from stronger workouts to little benefit or falling strength. Its reputation as a mild alternative does not reliably predict sleep, hormone or bloodwork effects.

A small molecule that acts at androgen receptors. SARM means selective androgen receptor modulator. ACP-105 was developed at ACADIA; partial agonism means it can stimulate the receptor less fully than testosterone in laboratory comparisons. Muscle selectivity in animals does not mean it acts only in a trained muscle or avoids hormonal effects elsewhere. Schlienger et al., 2009 — discovery abstract and preserved assay number (Official context · Accessed 2026-09-30)

Community use centers on oral liquids and capsules. These are unapproved research products, not peptides or established hormone replacement. Holding a liquid under the tongue also appears in an isolated report, with burning and bad taste; that does not establish a separate absorbed dose or equivalent timing. ACP-105 — first-day sublingual report (Personal report · Accessed 2026-09-30) · FDA — risks of bodybuilding products containing SARMs (Official context · Accessed 2026-09-30)

Source context — Schlienger et al., 2009 — discovery abstract and preserved assay number: PubMed abstract body inspected; it does not contain the 5.0-hour assay table. ACS full-text access failed, and a PDF mirror timed out; the cell number is a preserved formal-record claim, explicitly not freshly verified. Source kind describes the original formal origin and must not supply practical community sections.

Source context — ACP-105 — first-day sublingual report: First-day report only, product formulation unverified, no route comparison or absorption measurement. Fifteen mg is reported labeled intake, not delivered systemic dose. Some replies are deleted or unexpanded.

Source context — FDA — risks of bodybuilding products containing SARMs: SARM/product-class warning, not an ACP-specific dose-risk curve or proof that ACP caused any particular forum event. Very short class-context paraphrase to limit shared-source reuse across batch.

What people notice

Pumps and definition	Some describe fuller muscles, visible veins and retained strength during a cut. These observations do not measure new muscle or fat loss.
Less benefit or weaker lifts	One six-week author lost strength from week three; others describe stronger workouts, little change or week-five fatigue.
Energy can disrupt sleep	Accounts include quick morning energy, headaches, interrupted sleep and feeling awake yet exhausted.

Notes

Muscle retention, vascularity and gym performance. One cutting account describes retained muscle and rising strength in a claimed 1,000-calorie deficit, but no bloodwork and doubts about product identity. Other users describe fuller muscles, visible veins or a dry look. These reports do not measure fat loss or prove new muscle tissue. ACP-105 is it worth it compared to other mild Sarms? (Community discussion · Accessed 2026-09-30) · has anyone tried acp-105 — favorable physique with adverse labs (Personal report · Accessed 2026-09-30)

Stronger and weaker workouts both appear. The six-week author reported losing 10–20 kg from lifts from week three, then returning to baseline a week after stopping. Replies describe the opposite; another describes week-five fatigue, bad mood and barely changed physique. An AnabolicMinds contributor reports an acquaintance noticing nothing after three weeks, with product identity uncertain. My experience with acp105 — strength loss, corrected daily dose and opposing replies (Community discussion · Accessed 2026-09-30) · lets talk acp-105 — three-week nonresponse claim (Secondhand community claim · Accessed 2026-09-30)

Energy can feel quick; workout changes may take weeks. The diary describes almost immediate morning energy during days 10–16 of repeated use. A 2026 contributor reports one to two weeks to notice it. Another log saw nothing in week one and more pumps in week two; a reply felt nothing on day two. ACP 105 Overview — diary and same-author hospital follow-up (Personal report · Accessed 2026-09-30) · ACP 105 has many ran this? — June 2026 experiences and disagreements (Community discussion · Accessed 2026-09-30) · My experience with acp105 — strength loss, corrected daily dose and opposing replies (Community discussion · Accessed 2026-09-30)

Sleep, headaches and temperament matter. Reports include insomnia severe enough to stop, early headaches, night waking, urination and feeling awake yet exhausted. A 2026 stack user describes a shorter temper. No hair loss in another person's run cannot rule it out; acne and hair-shedding concerns remain in the community record. ACP-105 is it worth it compared to other mild Sarms? (Community discussion · Accessed 2026-09-30) · ACP 105 has many ran this? — June 2026 experiences and disagreements (Community discussion · Accessed 2026-09-30)

Source context — ACP-105 is it worth it compared to other mild Sarms?: Dose reply present in search extraction was not expanded in the opened body, so the 10–15 mg/day three-way split was not used as freshly body-verified evidence. Favorable user explicitly had no bloodwork; separate insomnia user provides no dose, and a later reply questions ACP versus AC-262 identity. Friends' bloodwork is secondhand, not measured primary evidence.

Source context — has anyone tried acp-105 — favorable physique with adverse labs: Deleted anonymous account, amount and product unspecified, no uploaded raw laboratory results; prior training, support supplements and subsequent enclomiphene confound interpretation. Normalization is self-reported. Vendor-affiliated sarmful opinions elsewhere in the thread are not treated as independent effectiveness evidence.

Source context — My experience with acp105 — strength loss, corrected daily dose and opposing replies: Anonymous reports, no verified chemistry or lab records; OP's original testosterone number/units are implausibly stated and not copied. DHT receptor-displacement explanation and assertion that every strong lifter loses strength are speculation. Some favorable replies involve Ostarine and cannot isolate ACP-105.

Source context — lets talk acp-105 — three-week nonresponse claim: An acquaintance's experience, not the poster's own ACP run; no dose, verified product or quantitative outcome. Other nonresponse and vascularity comments discuss Ostarine and were not transferred to ACP-105. Removed study links cannot be inspected.

Source context — ACP 105 Overview — diary and same-author hospital follow-up: One changing self-experiment, 21-year-old author, 3 AM work schedule, altered calories, flu and antibiotics, unverified product and medical records. Opening 17 mg differs from a reply's 8.5 plus 8 mg; exact delivered dose is unresolved. About eight hours is subjective fading, not half-life. A commenter with no day-two effect is a separate person. No causal kidney diagnosis is established.

Source context — ACP 105 has many ran this? — June 2026 experiences and disagreements: Same usernames also appear in other threads, so reports are not independent samples. No verified lab panels or chemical analysis. OP uses TRT and hair drugs; that context is not assigned to every commenter. Coach-style 10/20/30 mg role charts, minimal-lipid-effect claim and maximum stack total are unsupported opinions, not prescriptions or risk assurances.

Doses people talk about

Oral logs: 10–20 mg/day	Examples include 10 mg/day then 20 mg/day, and 15 mg/day divided into three 5 mg doses. One diary's claimed 17 mg total conflicts with a later component sum.
Other chart bands	Charts circulate 10–12, 15–25 and 25–30 mg/day. The 11–12 mg claim for a 79 kg person comes from a mouse-dose conversion, not observed human benefit.
Female chart talk	Single-digit amounts to 5–10 mg/day appear in sparse guides. Their amounts and proposed ceilings do not establish protection from virilizing changes.

Notes

Oral logs: 10–20 mg total per day. A 2026 account describes 10 mg/day for a month, then 20 mg/day. A six-week log clarifies 15 mg/day as three 5 mg doses. The eight-week diary states 17 mg/day in two portions eight hours apart, with a 24 mg day; a later reply says 8.5 plus 8 mg, inconsistent with that total. ACP 105 has many ran this? — June 2026 experiences and disagreements (Community discussion · Accessed 2026-09-30) · My experience with acp105 — strength loss, corrected daily dose and opposing replies (Community discussion · Accessed 2026-09-30) · ACP 105 Overview — diary and same-author hospital follow-up (Personal report · Accessed 2026-09-30)

Charts also circulate 10–12, 15–25 and 25–30 mg/day. Some extend the upper band to 15–30 mg/day. Those chart bands are separate from individual logs. The roughly 11–12 mg/day claim for a 79 kg person comes from converting a mouse 1 mg/kg/day experiment, not observing human benefit or safety.

Female chart talk: single-digit amounts to 5–10 mg/day. Some blogs add an unvalidated 15 mg ceiling. These sparse discussions do not establish protection from voice, hair, menstrual or other virilizing changes.

Half-life, onset & duration

Felt onset	Some report changes in one to two weeks, with pumps appearing in week two. One repeated-use diary describes almost immediate morning energy.
Felt duration	One diary describes energy fading after roughly eight hours; another user reports fullness through the day. Neither establishes a reliable single-dose window.
Half-life	No measured human value is established here. The circulated 12–16 hours is unverified; eight-hour tiredness returning is a felt effect, not clearance.

Notes

One diary estimates roughly eight hours of energy. This was tiredness returning after morning use, not a timed single-dose test. Another user describes fullness throughout the day. Lasting muscle retention after stopping, a reliable workout window and recovery timing remain unestablished. ACP 105 Overview — diary and same-author hospital follow-up (Personal report · Accessed 2026-09-30) · has anyone tried acp-105 — favorable physique with adverse labs (Personal report · Accessed 2026-09-30)

The circulated 12–16-hour figure is unverified. Older blog/vendor lore uses it to justify once-daily use. Forum replies instead call ACP-105 short-lived and favor two or three portions. Neither position establishes measured human elimination; a user's roughly eight-hour wear-off belongs to felt duration. My experience with acp105 — strength loss, corrected daily dose and opposing replies (Community discussion · Accessed 2026-09-30) · ACP 105 has many ran this? — June 2026 experiences and disagreements (Community discussion · Accessed 2026-09-30)

Cycles people discuss

Six- and eight-week accounts	Charts also span 4–6 to 8–12 weeks, occasionally 8–13. One person stopped after one to two weeks because sleep fell to about four hours.
Recovery discussion	Accounts disagree about no post-cycle therapy versus enclomiphene or tamoxifen. Equal time off and on is a forum habit, without a validated recovery calendar.

Notes

Six- and eight-week accounts; early stops also occur. One user stopped after one to two weeks because sleep fell to about four hours. Older charts span 4–6, 6–8, 8–12 and occasionally 8–13 weeks; female charts discuss 6–8. These lengths are not tested safety windows, and continuous bridge/cruise use lacks a validated basis. My experience with acp105 — strength loss, corrected daily dose and opposing replies (Community discussion · Accessed 2026-09-30) · ACP 105 has many ran this? — June 2026 experiences and disagreements (Community discussion · Accessed 2026-09-30) · ACP-105 is it worth it compared to other mild Sarms? (Community discussion · Accessed 2026-09-30)

PCT and time off are disputed. Post-cycle therapy means attempted hormone recovery. Discussion ranges from none to enclomiphene or tamoxifen; examples include tamoxifen 20 mg/day for four weeks or ACP-105 10 mg/day with enclomiphene around 12.5 mg. Off-time-equals-on-time and pre-, week-four and post-cycle tests are forum habits, not validated recovery. Discussed panels include testosterone, LH, FSH, estradiol, blood counts, liver enzymes and lipids.

Stacks

Ostarine or AC-262536	Accounts include ACP-105 with Ostarine and a separate AC-262536 combination. Stronger lifts, fading effects and adverse cholesterol appear; multiple drugs prevent isolating ACP-105.
Other partners and support	Cardarine, RAD-140, LGD-4033 and enclomiphene appear in discussion. NAC, TUDCA and fish or krill oil did not prevent adverse labs in every account.

Notes

Stack outcomes cannot isolate ACP-105. A 2026 reply lists ACP-105 10 with AC-262536 20 (mg in the thread's context; daily frequency unstated), later enclomiphene, stronger lifts and adverse cholesterol. Another adds ACP-105 10 mg/day in two 5 mg portions to Ostarine 20 mg/day: initial strength effects faded within a week. An older example pairs ACP-105 7 mg with Ostarine 17.5 mg, without stated frequency. Other partners include Cardarine, RAD-140 and LGD-4033; premixed ratios vary. ACP 105 whit ac 262? — stack results and objection (Community discussion · Accessed 2026-09-30) · My experience with acp105 — strength loss, corrected daily dose and opposing replies (Community discussion · Accessed 2026-09-30)

Pre-workout and protection claims are habits, not guarantees. Some logs describe a portion about 30 minutes before training, while split versus once-daily use remains disputed. NAC, TUDCA, fish/krill oil and other support supplements recur, yet adverse labs still occur. Training, protein, calories and sleep also change the result, making dose escalation an unreliable explanation for nonresponse. has anyone tried acp-105 — favorable physique with adverse labs (Personal report · Accessed 2026-09-30)

Enclomiphene co-therapy: Low-dose enclomiphene on-cycle or as PCT bridge to blunt HPTA shutdown narratives. [community]

Source context — ACP 105 whit ac 262? — stack results and objection: The stack reply omits units for its 20/10 values and does not expressly state daily frequency; the article retains component amounts in the thread's mg context without inventing a measured ratio or regimen. Multiple drugs prevent ACP-specific attribution. Unverified biomarker and 30% lift-increase claims; repeated users elsewhere are not new independent cases.

Watch for

Hormones, cholesterol and liver	A pleased user still reported abnormal cholesterol, raised liver enzymes and low testosterone. Feeling good did not predict their bloodwork.
Sleep and temperament	Reports include severe insomnia, headaches, night waking and a shorter temper. Some stopped because of these effects.
Hospital story needs its follow-up	An initial kidney-inflammation claim later included flu, antibiotics, intestinal blockage and relief after an enema. The account does not confirm kidney disease or show that ACP-105 caused it.
Product uncertainty	Unapproved SARM products carry liver and cardiovascular warnings; a label does not establish contents. SARMs are prohibited in tested sport.

Notes

Feeling good can coexist with adverse bloodwork. A pleased user reports out-of-range HDL and LDL cholesterol, elevated liver enzymes and below-range testosterone, despite support supplements. They reported normalization a month later after enclomiphene; that is one recovery account, not a dependable calendar. Reduced morning erections, libido, mood and energy also appear in older reports. has anyone tried acp-105 — favorable physique with adverse labs (Personal report · Accessed 2026-09-30)

The hospital account has a consequential follow-up. The eight-week diarist initially described kidney inflammation. Later replies added flu, antibiotics and intestinal blockage, then a return visit, MRI review and relief after an enema. Retaining that full sequence matters: neither a verified kidney diagnosis nor ACP-105 causality follows from this account. ACP 105 Overview — diary and same-author hospital follow-up (Personal report · Accessed 2026-09-30)

Unapproved products carry wider risks. FDA warns of serious liver and cardiovascular harm with SARM products; labels do not establish contents. SARMs are prohibited under WADA's 2026 list. No approved physique dose, product-purity assurance or harmless stack follows from this discussion. FDA — risks of bodybuilding products containing SARMs (Official context · Accessed 2026-09-30) · WADA 2026 Prohibited List — S1.2 (Official context · Accessed 2026-09-30)

Source context — WADA 2026 Prohibited List — S1.2: Class prohibition; ACP-105 need not be named in the non-exhaustive examples. This is a sport rule, not a general legal or product-quality certification. Only the class-prohibition sentence is derived from this source.

Full notes

What ACP-105 actually is

A small molecule that acts at androgen receptors. SARM means selective androgen receptor modulator. ACP-105 was developed at ACADIA; partial agonism means it can stimulate the receptor less fully than testosterone in laboratory comparisons. Muscle selectivity in animals does not mean it acts only in a trained muscle or avoids hormonal effects elsewhere. Official context
Community use centers on oral liquids and capsules. These are unapproved research products, not peptides or established hormone replacement. Holding a liquid under the tongue also appears in an isolated report, with burning and bad taste; that does not establish a separate absorbed dose or equivalent timing. Personal report Official context Community

What people hope to get from it

Muscle retention, vascularity and gym performance. One cutting account describes retained muscle and rising strength in a claimed 1,000-calorie deficit, but no bloodwork and doubts about product identity. Other users describe fuller muscles, visible veins or a dry look. These reports do not measure fat loss or prove new muscle tissue. Reddit Personal report
Comparisons disagree. Some rate ACP-105 above Ostarine or AC-262536; earlier discussion likens it to Andarine without vision changes. These are subjective comparisons, not evidence of equal effects, reliably absent eye problems or a better safety profile. Reddit AnabolicMinds

Doses people discuss

Reported amounts describe self-experiments and circulated charts, not a validated dose or personal regimen.

Oral logs: 10–20 mg total per day. A 2026 account describes 10 mg/day for a month, then 20 mg/day. A six-week log clarifies 15 mg/day as three 5 mg doses. The eight-week diary states 17 mg/day in two portions eight hours apart, with a 24 mg day; a later reply says 8.5 plus 8 mg, inconsistent with that total. Reddit Reddit Personal report
Charts also circulate 10–12, 15–25 and 25–30 mg/day. Some extend the upper band to 15–30 mg/day. Those chart bands are separate from individual logs. The roughly 11–12 mg/day claim for a 79 kg person comes from converting a mouse 1 mg/kg/day experiment, not observing human benefit or safety. Community
Female chart talk: single-digit amounts to 5–10 mg/day. Some blogs add an unvalidated 15 mg ceiling. These sparse discussions do not establish protection from voice, hair, menstrual or other virilizing changes. Community

Half-life claims

The circulated 12–16-hour figure is unverified. Older blog/vendor lore uses it to justify once-daily use. Forum replies instead call ACP-105 short-lived and favor two or three portions. Neither position establishes measured human elimination; a user's roughly eight-hour wear-off belongs to felt duration. Community Reddit Reddit

When people notice a change

Energy can feel quick; workout changes may take weeks. The diary describes almost immediate morning energy during days 10–16 of repeated use. A 2026 contributor reports one to two weeks to notice it. Another log saw nothing in week one and more pumps in week two; a reply felt nothing on day two. Personal report Reddit Reddit

How long effects feel noticeable

One diary estimates roughly eight hours of energy. This was tiredness returning after morning use, not a timed single-dose test. Another user describes fullness throughout the day. Lasting muscle retention after stopping, a reliable workout window and recovery timing remain unestablished. Personal report Personal report

Cycles and recovery discussion

Six- and eight-week accounts; early stops also occur. One user stopped after one to two weeks because sleep fell to about four hours. Older charts span 4–6, 6–8, 8–12 and occasionally 8–13 weeks; female charts discuss 6–8. These lengths are not tested safety windows, and continuous bridge/cruise use lacks a validated basis. Reddit Reddit Reddit Community
PCT and time off are disputed. Post-cycle therapy means attempted hormone recovery. Discussion ranges from none to enclomiphene or tamoxifen; examples include tamoxifen 20 mg/day for four weeks or ACP-105 10 mg/day with enclomiphene around 12.5 mg. Off-time-equals-on-time and pre-, week-four and post-cycle tests are forum habits, not validated recovery. Discussed panels include testosterone, LH, FSH, estradiol, blood counts, liver enzymes and lipids. Community

What can go wrong

Feeling good can coexist with adverse bloodwork. A pleased user reports out-of-range HDL and LDL cholesterol, elevated liver enzymes and below-range testosterone, despite support supplements. They reported normalization a month later after enclomiphene; that is one recovery account, not a dependable calendar. Reduced morning erections, libido, mood and energy also appear in older reports. Personal report Community
Sleep, headaches and temperament matter. Reports include insomnia severe enough to stop, early headaches, night waking, urination and feeling awake yet exhausted. A 2026 stack user describes a shorter temper. No hair loss in another person's run cannot rule it out; acne and hair-shedding concerns remain in the community record. Reddit Reddit Community
The hospital account has a consequential follow-up. The eight-week diarist initially described kidney inflammation. Later replies added flu, antibiotics and intestinal blockage, then a return visit, MRI review and relief after an enema. Retaining that full sequence matters: neither a verified kidney diagnosis nor ACP-105 causality follows from this account. Personal report
Unapproved products carry wider risks. FDA warns of serious liver and cardiovascular harm with SARM products; labels do not establish contents. SARMs are prohibited under WADA's 2026 list. No approved physique dose, product-purity assurance or harmless stack follows from this discussion. Official context Official context

Supporting research context

Cell stability and computer predictions are separate clocks. The earlier record cites 5.0 hours in human liver cells; the original assay table was not accessible in this refresh. The 2025 ADMETlab model predicts 1.182 hours in plasma. Neither is volunteer pharmacokinetics. CYP3A4 metabolism and reactive-metabolite warnings are predictions, not measured interactions or demonstrated human poisoning. Official context Official context
Animal findings do not establish human muscle or cognition benefits. The discovery abstract reports anabolic changes in castrated rats. Mouse cognition work and prostate-sparing claims remain preclinical. The circulated 3.19:1 anabolic-to-androgenic ratio also comes from early comparisons; none establish human gains or mild suppression. Official context Official context Community

What community experiences add

Stronger and weaker workouts both appear. The six-week author reported losing 10–20 kg from lifts from week three, then returning to baseline a week after stopping. Replies describe the opposite; another describes week-five fatigue, bad mood and barely changed physique. An AnabolicMinds contributor reports an acquaintance noticing nothing after three weeks, with product identity uncertain. Reddit AnabolicMinds
A dry look can cost more than the result feels worth. The diary's final weight was 75.3 kg versus 74 kg initially, with peak pumps around week four and a 6/10 verdict. Calories, illness and dose changes complicate it. Pain relief in knees/wrists and mental-clarity comments are isolated observations, not established therapeutic benefits. Personal report
Stack outcomes cannot isolate ACP-105. A 2026 reply lists ACP-105 10 with AC-262536 20 (mg in the thread's context; daily frequency unstated), later enclomiphene, stronger lifts and adverse cholesterol. Another adds ACP-105 10 mg/day in two 5 mg portions to Ostarine 20 mg/day: initial strength effects faded within a week. An older example pairs ACP-105 7 mg with Ostarine 17.5 mg, without stated frequency. Other partners include Cardarine, RAD-140 and LGD-4033; premixed ratios vary. Reddit Reddit Community
Pre-workout and protection claims are habits, not guarantees. Some logs describe a portion about 30 minutes before training, while split versus once-daily use remains disputed. NAC, TUDCA, fish/krill oil and other support supplements recur, yet adverse labs still occur. Training, protein, calories and sleep also change the result, making dose escalation an unreliable explanation for nonresponse. Community Personal report Community